Studies are continuing on the phenomenology associated with the action of streptomycin (SM) and several other aminoglycoside antibiotics on E. coli. Studies are underway on the mechanism by which these antibiotics interact with the ribosome and interrupt protein synthesis. Effort is also being devoted to obtaining a better understanding of the various phenotypes produced by mutations at the str locus, and by genetic suppression of these mutations. The question of ribosome turnover and biogenesis is also being explored as there appears to be an assembly defect in a majority of these mutants.
NIH ExPorter
NIH ExPorter