Investigation on the conformation of the hemoglobin system has shown that there is the possibility that internal degree of rotational freedom exist in the protein; that the substitution of one amino acid can have a long range conformational effect on both liganded and unliganded hemoglobin; that the stability of the secondary structure of the protein seems to be independent from the presence of the heme, and from the length of the polypeptide chain.
NIH ExPorter
NIH ExPorter