pirtobrutinib,Venetoclax,Ibrutinib
eli lilly,Janssen,Abbvie,roche
['cll', 'pirto']
tantawy et al #ash22
23 pts with pirto resist cll
baseline c481 a/w pd on pirto, but c481 clone usually replaced by kinase-dead mut (l528w, t474i)
interestingly, cll cells post pirto were sensitised to ven+ibr
is dead-kinase mut cll dependent on alt kinase blocked by ibr? 
Doc from Melbourne, Australia. Treats patients with blood cancers and researches new therapies. Loves family, immersive theatre and running.