eculizumab,iptacopan,Ravulizumab
Alexion Pharmaceuticals,novartis
['concept trial', 'obinu', 'irene', 'eculizumab']
#ash22 de latour: apply-pnh trial: oral iptacopan superior to iv eculizumab or ravulizumab in pnh. iptacobaj inhibits c3 convertase vs the mabs inhibit c5. randomized 8:5 to iptacoban vs iv mab for 24wks followed by iptacoban for all. 
Assoc Professor, UCSF hematology/BMT. Translational researcher interested in leukemia, MDS, MRD, post-HCT relapse, GVHD, & immune recon. Photos: pyknosis (IG)