pirtobrutinib,nx-2127
eli lilly,nurix therapeutics
['nx-2127 ', 'pirto', 'nx-2127', 'cll', 'nx,2127,001']
brilliant work abdel-wahab #ash22 #cll
kinase dead (d) btk mutations, like l528w, seen esp with pirto/zanu
dbtk restore bcr signalling by ^^ interaction with lyn, hck, syk others (scaffolding)
protac degrad of btk active across muts, pt data too
will these muts guide sequencing? 
Doc from Melbourne, Australia. Treats patients with blood cancers and researches new therapies. Loves family, immersive theatre and running.