macitentan,tadalafil
janssen,Actelion
[]
 strong dual therapy provoked aes leading to discontinuation, son probably underpowered.
if a pah pt needs dual tx, you should uptitrate slowly to avoid systemic hypotension amd withdrawal. and then, 6mwt diff may appear a bit later (6months)
MD Cardiology, Pharmacology 🇦🇷  Emerging Leader WHF & SIAC. HF, PAH, CVpharm, OACs, HTN, ChagasDis, Obesity, Diabetes, Lipids, GlobalHealth. Opinions my own.