tipifarnib
kura oncology
['tipifarnib', 'affinit']
mccormick #aacr23 tipifarnib tested in hras mutant cancers. 1992: how to target ras directly? resistant to gap, indifferent to rtks, high affinity (10pm) to gtp, what to do? w/o the tools we have know (direct binders to protein), looked downstream.
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