blinatumomab
amgen,crispr,astellas
['blinatumomab', 'leusm', 'crispr']
#ash22 #leusm li: progression after blin due to cd19 loss in a minority (36% quoted here but literature in gen supports rate ~10%). to determine causes of cd19+ progression after blin this group did crispr screen to id cd58 downregulation assoc with blin failure. 
Assoc Professor, UCSF hematology/BMT. Translational researcher interested in leukemia, MDS, MRD, post-HCT relapse, GVHD, & immune recon. Photos: pyknosis (IG)