emavusertib,azacitidine,venetoclax
curis,Roche,AbbVie
['leusm', 'aml,(-streamline),(-seamless),(-kamloops)', 'mds', 'emavusertib']
#asco22 #leusm menghrajani: sf3b1 and u2af1 muts lead to overactivation of nfkb signaling via overexpr of irak4-long isoform. irak4i, emavusertib, shows promise as monotherapy in dose esc in pts w hr-mds/aml. more crs seen in those w spliceosome muts. ema/aza+/-ven underway. 
Assoc Professor, UCSF hematology/BMT. Translational researcher interested in leukemia, MDS, MRD, post-HCT relapse, GVHD, & immune recon. Photos: pyknosis (IG)