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['cardio']
 in mice...which breath 155 times per minute, put in closed cages and blasted with nicotine vapor every day, day-after-day... in humans, quitting smoking with nicotine vapes dramatically lowers cardiovascular risks according to association. 
Neurobiologist; 25 yrs in global health; advocate for ex-smokers who use safer nicotine.  Goal:  I use evidence to kill Big Tobacco's main cash cow:  Cigarettes