Valsartan,sacubitril
Novartis
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there was safety concerns associated with the chronic use of neprilysin inhibitors especially in patients at-risk of ad (e.g. genetic factors,vascular factors, mild cognitive impairment). this issue has been clearly addressed in perspective trial: sac/vals safe!! #esccongress 
Cardiólogo. Unidad de Insuficiencia Cardiaca Avanzada y Trasplante Cardiaco. Hospital Universitario de Bellvitge. L'Hospitalet del Llobregat. Barcelona