Talazoparib,Enzalutamide
Pfizer,Astellas
['talapro,2', 'pivotal data', 'brca', 'crpc', 'talapro-2']
#asco23 karim fizazi presents hrr-def cohort from talapro-2 (enza + tala vs pbo + tala) in mcrpc. sig in rpfs (hr 0.45) with encouraging early os signal (hr 0.69) - brca1/2 (hr 0.61) &amp; non-brca (hr 0.66). these pivotal data reinforce role of nha + parp in hrr-def pts. 
GU Med Onc, A/Prof Peter Mac/UoM, ANZUP Translational Chair, #UpfrontPSMA Alliance, COSA Urologic Oncology Chair, NHMRC L1 Investigator. Opinions my own.