ponatinib
takeda,otsuka,incyte
['ponatinib', 'cml']
update from optic study at #ash22- in a highly resistant cp-cml population, the ideal dosage of ponatinib appears to be a starting dose of 45 mg/d with reduction to 15 mg/d when 1% bcr::abl1is is reached. high efficacy and manageable safety remain consistent at the 3-year mark! 