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in polyrefractory ra patients, half did not have any pdus change on ultrasound and/or had normal crp levels, showing that in the other half, new mechanisms of action for treatment is required by david p, abst#op0134 ##eular2023 
MD PhD Consultant Rheumatologist &Physician,Assoc Medical Director,Digital Health,NASS Trustee, Best Rheum Care,Visiting Fellow Henley Business School,ExecCoach