nivolumab,ipilimumab
bms
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 any mutational process resulting in extensively high tmb will behave the same. msi is just the easiest way to quantify very high tmb. pole/d a bit harder but judiciously done, will be impactful. the point is of course, time and time again, super high mutation= good io results
Chair, Immunotherapy Center, Cleveland Clinic Health System, @ClevelandClinic; Professor; fan of tennis, coral reefs, and Lego building;  views my own