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['lupus']
an overlooked fact about cd19-targeted car-t cells (+ conditioning w cyc/fludarabine) in lupus is that it normalized ifna in all patients. if confirmed with more dedicated analysis, depleting b cells may be sufficient to normalize the interferon signature. #acr22
rheumatologist @johnshopkins & @ludwig_cancer | via @mghmedicine @chariteberlin | passionate about immunoengineering/CAR-T cell therapy for rheumatic diseases