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['#gu,(-#gui),(-#gunagratinib),(-#guard),(-#gut)', 'bladder']
great question. my opinion is that for small trials, proof of concept it is reasonable. but for large phase 3 looking at clinical practice change, os is mandatory as primary endpoint, with or without bladder sparing as co-primary #gu23 
Scientific Committee Member LACOG - GU. Medical Oncologist at Hospital Albert Einstein and CPO. Owner and founder BIO. Following or RT does not mean endorsement