pirtobrutinib,nx-2127
eli lilly,nurix therapeutics
['nx-2127 ', 'dlbcl', 'pirto', 'nx-2127', 'nhl', 'cll', 'nx,2127,001']
mato #cll #ash22
novel btk degrader nx-2127 with action against btkmut cll (incl dead kinase)
phase 1 rr cll 2 prior lot
n=23, 80% prior btki &amp; bcl2i
g 3 haem tox, af (?why, pre existing in some)
orr 33%, 14/23 pts on drug at 16m fu
interesting moa, but more pts/fu needed 
Doc from Melbourne, Australia. Treats patients with blood cancers and researches new therapies. Loves family, immersive theatre and running.