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| Rabbit   | R Documentation   |
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Blood Pressure in Rabbits
-------------------------

Description
~~~~~~~~~~~

Five rabbits were studied on two occasions, after treatment with saline
(control) and after treatment with the *5-HT\_3* antagonist MDL 72222.
After each treatment ascending doses of phenylbiguanide were injected
intravenously at 10 minute intervals and the responses of mean blood
pressure measured. The goal was to test whether the cardiogenic
chemoreflex elicited by phenylbiguanide depends on the activation of
*5-HT\_3* receptors.

Usage
~~~~~

::

    Rabbit

Format
~~~~~~

This data frame contains 60 rows and the following variables:

``BPchange``
    change in blood pressure relative to the start of the experiment.

``Dose``
    dose of Phenylbiguanide in micrograms.

``Run``
    label of run (``"C1"`` to ``"C5"``, then ``"M1"`` to ``"M5"``).

``Treatment``
    placebo or the *5-HT\_3* antagonist MDL 72222.

``Animal``
    label of animal used (``"R1"`` to ``"R5"``).

Source
~~~~~~

J. Ludbrook (1994) Repeated measurements and multiple comparisons in
cardiovascular research. *Cardiovascular Research* **28**, 303â€“311.
 [The numerical data are not in the paper but were supplied by Professor
Ludbrook]

References
~~~~~~~~~~

Venables, W. N. and Ripley, B. D. (2002) *Modern Applied Statistics with
S.* Fourth edition. Springer.
