+--------+-------------------+
| mgus   | R Documentation   |
+--------+-------------------+

Monoclonal gammapothy data
--------------------------

Description
~~~~~~~~~~~

Natural history of 241 subjects with monoclonal gammapothy of
undetermined significance (MGUS).

Usage
~~~~~

::

    mgus
    mgus1
    mgus2

Format
~~~~~~

mgus: A data frame with 241 observations on the following 12 variables.

+-----------+----------------------------------------------------------------------+
| id:       | subject id                                                           |
+-----------+----------------------------------------------------------------------+
| age:      | age in years                                                         |
+-----------+----------------------------------------------------------------------+
| sex:      | ``male`` or ``female``                                               |
+-----------+----------------------------------------------------------------------+
| dxyr:     | year of diagnosis                                                    |
+-----------+----------------------------------------------------------------------+
| pcdx:     | for subjects who progress to a plasma cell malignancy                |
+-----------+----------------------------------------------------------------------+
|           | the subtype of malignancy: multiple myeloma (MM) is the              |
+-----------+----------------------------------------------------------------------+
|           | most common, followed by amyloidosis (AM), macroglobulinemia (MA),   |
+-----------+----------------------------------------------------------------------+
|           | and other lymphprolifative (LP)                                      |
+-----------+----------------------------------------------------------------------+
| pctime:   | days from MGUS until diagnosis of a plasma cell malignancy           |
+-----------+----------------------------------------------------------------------+
| futime:   | days from diagnosis to last follow-up                                |
+-----------+----------------------------------------------------------------------+
| death:    | 1= follow-up is until death                                          |
+-----------+----------------------------------------------------------------------+
| alb:      | albumin level at MGUS diagnosis                                      |
+-----------+----------------------------------------------------------------------+
| creat:    | creatinine at MGUS diagnosis                                         |
+-----------+----------------------------------------------------------------------+
| hgb:      | hemoglobin at MGUS diagnosis                                         |
+-----------+----------------------------------------------------------------------+
| mspike:   | size of the monoclonal protien spike at diagnosis                    |
+-----------+----------------------------------------------------------------------+
+-----------+----------------------------------------------------------------------+

mgus1: The same data set in start,stop format. Contains the id, age,
sex, and laboratory variable described above along with

+----------------+-------------------------------------------------+
| start, stop:   | sequential intervals of time for each subject   |
+----------------+-------------------------------------------------+
| status:        | =1 if the interval ends in an event             |
+----------------+-------------------------------------------------+
| event:         | the event type                                  |
+----------------+-------------------------------------------------+
+----------------+-------------------------------------------------+

mgus2: The mgus data, but formatted in the competing risks style. Each
subject has three observations, one for time to death, one for time to
MM, and one for time to a PC malignancy other than MM. Contains the id,
age, sex, and laboratory variable described above along with

+-----------+---------------------------------------+
| time:     | time to event or censoring            |
+-----------+---------------------------------------+
| status:   | 1 if the event occured, 0 otherwise   |
+-----------+---------------------------------------+
| event:    | death, myeloma, or other              |
+-----------+---------------------------------------+
+-----------+---------------------------------------+

Details
~~~~~~~

Plasma cells are responsible for manufacturing immunoglobulins, an
important part of the immune defense. At any given time there are
estimated to be about *10^6* different immunoglobulins in the
circulation at any one time. When a patient has a plasma cell malignancy
the distribuion will become dominated by a single isotype, the product
of the malignant clone, visible as a spike on a serum protein
electrophoresis. Monoclonal gammapothy of undertermined significance
(MGUS) is the presence of such a spike, but in a patient with no
evidence of overt malignancy. This data set of 241 sequential subjects
at Mayo Clinic was the groundbreaking study defining the natural history
of such subjects.

Source
~~~~~~

Mayo Clinic data courtesy of Dr. Robert Kyle.

References
~~~~~~~~~~

R Kyle, Benign monoclonal gammopathy â€“ after 20 to 35 years of
follow-up, Mayo Clinic Proc 1993; 68:26-36.
