+---------+-------------------+
| colon   | R Documentation   |
+---------+-------------------+

Chemotherapy for Stage B/C colon cancer
---------------------------------------

Description
~~~~~~~~~~~

These are data from one of the first successful trials of adjuvant
chemotherapy for colon cancer. Levamisole is a low-toxicity compound
previously used to treat worm infestations in animals; 5-FU is a
moderately toxic (as these things go) chemotherapy agent. There are two
records per person, one for recurrence and one for death

Usage
~~~~~

::

    colon

Format
~~~~~~

+-------------+-------------------------------------------------------------------------------------+
| id:         | id                                                                                  |
+-------------+-------------------------------------------------------------------------------------+
| study:      | 1 for all patients                                                                  |
+-------------+-------------------------------------------------------------------------------------+
| rx:         | Treatment - Obs(ervation), Lev(amisole), Lev(amisole)+5-FU                          |
+-------------+-------------------------------------------------------------------------------------+
| sex:        | 1=male                                                                              |
+-------------+-------------------------------------------------------------------------------------+
| age:        | in years                                                                            |
+-------------+-------------------------------------------------------------------------------------+
| obstruct:   | obstruction of colon by tumour                                                      |
+-------------+-------------------------------------------------------------------------------------+
| perfor:     | perforation of colon                                                                |
+-------------+-------------------------------------------------------------------------------------+
| adhere:     | adherence to nearby organs                                                          |
+-------------+-------------------------------------------------------------------------------------+
| nodes:      | number of lymph nodes with detectable cancer                                        |
+-------------+-------------------------------------------------------------------------------------+
| time:       | days until event or censoring                                                       |
+-------------+-------------------------------------------------------------------------------------+
| status:     | censoring status                                                                    |
+-------------+-------------------------------------------------------------------------------------+
| differ:     | differentiation of tumour (1=well, 2=moderate, 3=poor)                              |
+-------------+-------------------------------------------------------------------------------------+
| extent:     | Extent of local spread (1=submucosa, 2=muscle, 3=serosa, 4=contiguous structures)   |
+-------------+-------------------------------------------------------------------------------------+
| surg:       | time from surgery to registration (0=short, 1=long)                                 |
+-------------+-------------------------------------------------------------------------------------+
| node4:      | more than 4 positive lymph nodes                                                    |
+-------------+-------------------------------------------------------------------------------------+
| etype:      | event type: 1=recurrence,2=death                                                    |
+-------------+-------------------------------------------------------------------------------------+
+-------------+-------------------------------------------------------------------------------------+

Note
~~~~

The study is originally described in Laurie (1989). The main report is
found in Moertel (1990). This data set is closest to that of the final
report in Moertel (1991). A version of the data with less follow-up time
was used in the paper by Lin (1994).

References
~~~~~~~~~~

JA Laurie, CG Moertel, TR Fleming, HS Wieand, JE Leigh, J Rubin, GW
McCormack, JB Gerstner, JE Krook and J Malliard. Surgical adjuvant
therapy of large-bowel carcinoma: An evaluation of levamisole and the
combination of levamisole and fluorouracil: The North Central Cancer
Treatment Group and the Mayo Clinic. J Clinical Oncology, 7:1447-1456,
1989.

DY Lin. Cox regression analysis of multivariate failure time data: the
marginal approach. Statistics in Medicine, 13:2233-2247, 1994.

CG Moertel, TR Fleming, JS MacDonald, DG Haller, JA Laurie, PJ Goodman,
JS Ungerleider, WA Emerson, DC Tormey, JH Glick, MH Veeder and JA
Maillard. Levamisole and fluorouracil for adjuvant therapy of resected
colon carcinoma. New England J of Medicine, 332:352-358, 1990.

CG Moertel, TR Fleming, JS MacDonald, DG Haller, JA Laurie, CM Tangen,
JS Ungerleider, WA Emerson, DC Tormey, JH Glick, MH Veeder and JA
Maillard, Fluorouracil plus Levamisole as and effective adjuvant therapy
after resection of stage II colon carcinoma: a final report. Annals of
Internal Med, 122:321-326, 1991.
