rnx.id	new.rev	rm.rxn	new.stoichiometry	comment	Reference 	note	abbreviation	name	forced.approval
rxn00318	>			[SW] Reaction never reported to be reversible.	http://www.brenda-enzymes.info/enzyme.php?ecno=3.5.1.17				
rxn00779	>			[SW] Enzyme reported predominantly to be irreversible.	http://www.brenda-enzymes.info/enzyme.php?ecno=1.2.1.9				
rxn02004	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.12				
rxn00743	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.12				
rxn01345	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.11				
rxn00001	>			[SW] Reaction may be only reversible if coupled with another reaction that provides energy.	"reaction may be reversed by coupling to glucose-6-phosphate to 6-phospho-gluconate" - Josse, J.; Wong, S.C.K.; The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ) 4, 499-527 (1971)				
rxn01173	>			[SW] Reaction irreversible.	Nakamura, K.; Bernheim, F.; Biochim. Biophys. Acta 50, 147-152 (1961)				
rxn00420	>			[SW] the enzyme catalyzes the final and irreversible step of L-serine synthesis	Jung, T.Y.; Kim, Y.S.; Oh, B.H.; Woo, E.; Proteins 81, 819-829 (2013)				
rxn00549	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.11#SUBSTRATE				
rxn00221	>			[SW] New direction according to Metacyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=GLUCOSE-1-PHOSPHAT-RXN				
rxn00610	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.21#SUBSTRATE				
rxn00220	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.58#SUBSTRATE				
rxn00391	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.102#SUBSTRATE				
rxn01172	>			[SW] Reaction irreversible.	Nakamura, K.; Bernheim, F.; Biochim. Biophys. Acta 50, 147-152 (1961)				
rxn00132	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.5#NATURAL%20SUBSTRATES				
rxn02058	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.50#NATURAL%20SUBSTRATES				
rxn00578	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.24#NATURAL%20SUBSTRATES				
rxn00632	>			[SW] Phosphatases usually not reversible. No BRENDA entry for this reaction.					
rxn01969	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.54#SUBSTRATE				
rxn02005	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn01560	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.22#SUBSTRATE				
rxn00126	>			[SW] Reaction never reported to be reversible, but reported irreversible in some cases.	https://www.brenda-enzymes.org/enzyme.php?ecno=2.5.1.6#SUBSTRATE				
rxn01282	>			[SW] Phosphatases usually not reversible. Reported irreversible.	James, L.; Schwartzbach, S.D.; Plant Sci. Lett. 27, 223-232 (1982)				
rxn01099	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.38#SUBSTRATE				
rxn00257	>			[SW] Reaction irreversible.	Chypre, M.; Zaidi, N.; Smans, K.; Biochem. Biophys. Res. Commun. 422, 1-4 (2012)				
rxn00934	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=6.2.1.9#SUBSTRATE				
rxn00767		TRUE		[SW] Enzyme not reported for microorganisms.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.7.1.79-RXN # https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.79				
rxn00971	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CITRATE--COA-LIGASE-RXN				
rxn00251	<			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=PEPCARBOX-RXN				
rxn00250	>			[SW] Reaction physiologically irreversible.	10.1016/j.femsre.2004.11.002				
rxn00533	>			[SW] Reaction most commonly reported irreversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=6.4.1.2#SUBSTRATE				
rxn01286	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=1.2.1.3#SUBSTRATE				
rxn00429	>			[SW] Reaction irreversible.	Ando, M.; Yoshimoto, T.; Ogushi, S.; Rikitake, K.; Shibata, S.; Tsuru, D.; J. Biochem. 85, 1165-1172 (1979)				
rxn01209		TRUE		[SW] Reaction cannot be found in any other database. Probably confused with RXN in Ref:	http://www.rhea-db.org/reaction?id=20221				
rxn00668	>			[SW] New direction according to Metacyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-8568				
rxn00375	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=3.5.1.68#SUBSTRATE				
rxn00183	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-14116				
rxn02915		TRUE		[SW] Reaction cannot be found in any other database.					
rxn02289	>			[SW] Reaction irreversible.	Nurmikko, V.; M??nts??l??, P.; Kuusikko, R.; Niemi, R.; Suom. Kemistil. B 44, 244-247 (1971)				
rxn00508	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN				
rxn00509	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN				
rxn05734		TRUE		[SW] Reaction cannot be found in any other database.					
rxn00148	<			[SW] Pyruvate kinase is irreversible under physiological conditions	Berg JM Tymoczko JL, Stryer L, Clarke ND (2002). Biochemistry (fifth ed.). New York, NY: W.H. Freeman. ISBN 978-0-7167-3051-4.				
rxn00840	<			[SW] Pyruvate kinase is irreversible under physiological conditions. Same as rxn00148, but with dATP as cofactor.	Berg JM Tymoczko JL, Stryer L, Clarke ND (2002). Biochemistry (fifth ed.). New York, NY: W.H. Freeman. ISBN 978-0-7167-3051-4.				
rxn01354	<			[SW] Pyruvate kinase is irreversible under physiological conditions. Same as rxn00148, but with dGTP as cofactor.	Berg JM Tymoczko JL, Stryer L, Clarke ND (2002). Biochemistry (fifth ed.). New York, NY: W.H. Freeman. ISBN 978-0-7167-3051-4.				
rxn00517	<			[SW] Pyruvate kinase is irreversible under physiological conditions. Same as rxn00148, but with ITP as cofactor.	Berg JM Tymoczko JL, Stryer L, Clarke ND (2002). Biochemistry (fifth ed.). New York, NY: W.H. Freeman. ISBN 978-0-7167-3051-4.				
rxn00304	<			[SW] Pyruvate kinase is irreversible under physiological conditions. Same as rxn00148, but with GTP as cofactor.	Berg JM Tymoczko JL, Stryer L, Clarke ND (2002). Biochemistry (fifth ed.). New York, NY: W.H. Freeman. ISBN 978-0-7167-3051-4.				
rxn00411	<			[SW] Pyruvate kinase is irreversible under physiological conditions. Same as rxn00148, but with CTP as cofactor.	Berg JM Tymoczko JL, Stryer L, Clarke ND (2002). Biochemistry (fifth ed.). New York, NY: W.H. Freeman. ISBN 978-0-7167-3051-4.				
rxn00460	<			[SW] Pyruvate kinase is irreversible under physiological conditions. Same as rxn00148, but with UTP as cofactor.	Berg JM Tymoczko JL, Stryer L, Clarke ND (2002). Biochemistry (fifth ed.). New York, NY: W.H. Freeman. ISBN 978-0-7167-3051-4.				
rxn01667	<			[SW] Pyruvate kinase is irreversible under physiological conditions. Same as rxn00148, but with NTP as cofactor.	Berg JM Tymoczko JL, Stryer L, Clarke ND (2002). Biochemistry (fifth ed.). New York, NY: W.H. Freeman. ISBN 978-0-7167-3051-4.				
rxn04036	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=R229-RXN				
rxn07847	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-2882				
rxn01077	>			[SW] New direction according to Metacyc. Never been reported reversible (BRENDA)	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLUCURONOKINASE-RXN # https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.43#				
rxn08684	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.31				
rxn08111	>			[SW] Reaction never reported to be reversible, but reported irreversible in some cases.	https://www.brenda-enzymes.org/enzyme.php?ecno=1.2.1.5#SUBSTRATE				
rxn09272	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN				
rxn00567	<		-1:cpd00001:1:0:"H2O";-1:cpd00109:0:0:"Cytochrome c3+";-1:cpd00418:1:0:"NO";2:cpd00067:0:0:"H+";1:cpd00075:1:0:"Nitrite";1:cpd00110:0:0:"Cytochrome c2+"	[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=NITRITE-REDUCTASE-CYTOCHROME-RXN				
rxn03585	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ARYL-ALDEHYDE-OXIDASE-RXN				
rxn03969	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.2.1.67-RXN				
rxn06106	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc	https://www.brenda-enzymes.org/enzyme.php?ecno=1.10.2.2#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-15816				
rxn06109	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN				
rxn08430	>			[SW] Phosphatases usually not reversible. Reported irreversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.10#SUBSTRATE				
rxn01952	<			[SW] Phosphatases usually not reversible. Reported irreversible.					
rxn08046	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn30248		TRUE		Stoichiometry incomplete. Missing PEP and Pyr (PTS permease)					
rxn05226	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn05485	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn05501	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn05518	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn05560	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn05567	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn05569	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn05607	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn05610	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn05617	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn05647	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn05655	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn08048	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn08535	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn09242	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn10865	>			[SW] PEP:PYR PTS is most likely irreversible.	10.1128/MMBR.00024-06				
rxn08948	>			[SW] Phosphatases usually not reversible.					
rxn02373	<			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLUTSEMIALDEHYDROG-RXN				
rxn09487	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-14116				
rxn08971	>			[SW] Reaction can only ybe reversed if coupled with proton import via complex.	http://www.sbcs.qmul.ac.uk/iubmb/enzyme/EC1/6/5/3.html				
rxn00207		TRUE		[SW] Reaction cannot be found in any other database. Maybe CO2 was confused with Co2+? This reaction exists.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.11.1.13				
rxn08188	>			[SW] Transporter is used to expell Calcium from the cell.	10.1016/0014-5793(93)80870-Z				
rxn10055	>			[SW] Reaction never reported to be reversible. Kinases are rarely rev. .	https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.73#SUBSTRATE				
rxn09010	>			[SW] Reaction never reported to be reversible. Phasphatases are rarely rev. .	https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.5#NATURAL%20SUBSTRATES				
rxn10558	>			[SW] ATPase that exports H+ (1ATP ??' 1H+(out)) works with this stoichiometry not in the other direction.					
rxn10058	>			[SW] NAD kinase ist irreversible	https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.23#NATURAL%20SUBSTRATES				
rxn10057	>			[SW] NAD kinase ist irreversible	https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.23#NATURAL%20SUBSTRATES				
rxn10056	>			[SW] NAD kinase ist irreversible	https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.23#NATURAL%20SUBSTRATES				
rxn10059	>			[SW] NAD kinase ist irreversible	https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.23#NATURAL%20SUBSTRATES				
rxn10060	>			[SW] NAD kinase ist irreversible	https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.23#NATURAL%20SUBSTRATES				
rxn00088	>			[SW] Phosphatases usually not reversible.					
rxn09967	>			[SW] irrev. According to reference.	Tamaki, N.; Hama, T.; Methods Enzymol. 89, 469-473 (1982)				
rxn00626	>			[SW] Reaction never reported to be reversible.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.1.2.2#SUBSTRATE				
rxn05115	=			[SW] Enzyme reported reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=5.4.99.18#NATURAL%20SUBSTRATES				
rxn10090	>			[SW] Reaction never reported to be reversible. Would otherwise build high-energy P-bonds	https://www.brenda-enzymes.org/enzyme.php?ecno=2.5.1.17#NATURAL%20SUBSTRATES				
rxn08110	>			[SW] Reaction never reported to be reversible.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.2.1.26#NATURAL%20SUBSTRATES				
rxn00146	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=D-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN				
rxn10091	>			[SW] Reaction never reported to be reversible.	http://www.brenda-enzymes.org/enzyme.php?ecno=2.5.1.17#NATURAL%20SUBSTRATES				
rxn01382	>			[SW] Reaction never reported to be reversible. Strongly exergonic reactions					
rxn10848	>			[SW] Reaction never reported to be reversible.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.6.5.2#NATURAL%20SUBSTRATES				
rxn10844	>			[SW] Reaction never reported to be reversible.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.6.5.2#NATURAL%20SUBSTRATES				
rxn00145	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN				
rxn00123	>			[SW] Reaction never reported to be reversible.	http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.74#NATURAL%20SUBSTRATES				
rxn08458	>			[SW] Reaction never reported to be reversible.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.5.1.37#NATURAL%20SUBSTRATES				
rxn15029	>			[SW] Reaction irreversible.	Kuang, Y.; Schomisch, S.J.; Chandramouli, V.; Lee, Z.; Comp. Biochem. Physiol. C 143, 225-231 (2006)				
rxn00703	>			[SW] Reaction never reported to be reversible.	http://www.brenda-enzymes.org/enzyme.php?ecno=2.4.1.139#NATURAL%20SUBSTRATES				
rxn01807	>			[SW] Reaction never reported to be reversible.	http://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.35#NATURAL%20SUBSTRATES				
rxn01396	>			[SW] Reaction never reported to be reversible.	http://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.35#NATURAL%20SUBSTRATES				
rxn09942		TRUE		[SW] Reaction cannot be found in any other database.					
rxn06060	>			[SW] Reaction irreversible.	https://metacyc.org/META/substring-search?type=NIL&object=2.8.1.3 # https://www.brenda-enzymes.org/enzyme.php?ecno=2.8.1.3#NATURAL%20SUBSTRATES				
rxn01671	>			[SW] Reaction never reported to be reversible.	http://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.22#NATURAL%20SUBSTRATES				
rxn10010	>			[SW] Reaction irreversible.	Hu, K.; Zhao, M.; Zhang, T.; Zha, M.; Zhong, C.; Jiang, Y.; Ding, J.; Biochem. J. 449, 79-89 (2013)				
rxn03031	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=TETHYDPICSUCC-RXN				
rxn01973	>			[SW] Reaction never reported to be reversible. Irrev. According to MetaCyc	http://www.brenda-enzymes.org/enzyme.php?ecno=3.5.1.18#NATURAL%20SUBSTRATES				
rxn11167		TRUE		[SW] Reaction unbalanced?					
rxn11339		TRUE		[SW] Reaction unbalanced?					
rxn10062	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-7230				
rxn08972	=		-1:cpd00004:0:0:"NADH";-5:cpd00067:0:0:"H+";-1:cpd15560:0:0:"Ubiquinone-8";1:cpd00003:0:0:"NAD";4:cpd00067:1:0:"H+";1:cpd15561:0:0:"Ubiquinol-8"	[SW] Reaction never reported to be reversible. [SW] Reverted back to original direction.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.6.5.3#NATURAL%20SUBSTRATES				
rxn03978	<			[SW] Reaction never reported to be reversible. Irrev. According to MetaCyc	http://www.brenda-enzymes.org/enzyme.php?ecno=1.7.2.2#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.7.2.2-RXN				
rxn11933	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-7229				
rxn01053	>			[SW] Reaction never reported to be reversible. Irrev. According to MetaCyc	http://www.brenda-enzymes.org/enzyme.php?ecno=1.2.1.22#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=LACTALDDEHYDROG-RXN				
rxn10126	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-14971				
rxn08521	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=NADPH-DEHYDROGENASE-FLAVIN-RXN				
rxn01618	<			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.1.1.283-RXN				
rxn08249		TRUE		[SW] Coprogen does not participate in any other reaction.					
rxn08247		TRUE		[SW] Coprogen does not participate in any other reaction.					
rxn08659	>			[SW] Reaction irreversible.	Misra, K.; Banerjee, A.B.; Ray, S.; Ray, M.; Biochem. J. 305, 999-1003 (1995)				
rxn10619	>			[SW] UNSURE. Changing stoichiometries. And its irreversible	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-14970				
rxn01972	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN				
rxn00149	>			[SW] Reaction never reported to be reversible. Irrev. According to MetaCyc	http://www.brenda-enzymes.org/enzyme.php?ecno=1.2.1.22#SUBSTRATE #3https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=METHYL-GLYOXAL-DEHYDROG-RXN				
rxn11342	>			[SW] PEP:PYR PTS is most likely irreversible.					
rxn01228	>			[SW] Phosphatases usually not reversible.					
rxn00150	>			[SW] Reaction never reported to be reversible. Irrev. According to MetaCyc	https://www.brenda-enzymes.org/enzyme.php?ecno=1.2.1.49#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2-OXOALDEHYDE-DEHYDROGENASE-NADP%2b-RXN				
rxn01273	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=LACTALDDEHYDROG-RXN				
rxn00011	<			[SW] Reaction is irreversible but in the other direction according to BRENDA and MetaCyc	http://www.brenda-enzymes.org/enzyme.php?ecno=1.2.4.1#NATURAL%20SUBSTRATES				
									
rxn08291	>			[SW] Reaction mainly irreversible according to BRENDA and MetaCyc	http://www.brenda-enzymes.org/enzyme.php?ecno=1.4.99.6#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-7563				
rxn00265	>			[SW] Reaction mainly irreversible according to BRENDA and MetaCyc	http://www.brenda-enzymes.org/enzyme.php?ecno=4.1.3.6#SUBSTRATE # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CITLY-RXN				
rxn00910	<			[SW] Reaction mainly irreversible according to BRENDA and MetaCyc	http://www.brenda-enzymes.org/enzyme.php?ecno=1.5.1.20#SUBSTRATE # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.5.1.20-RXN				
rxn04954	<			[SW] Reaction mainly irreversible according to BRENDA and MetaCyc	http://www.brenda-enzymes.org/enzyme.php?ecno=1.5.1.20#SUBSTRATE # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.5.1.20-RXN				
rxn01874	>			[SW] Reaction irreversible according to BRENDA and MetaCyc	http://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.96#SUBSTRATE # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=THIOETHER-S-METHYLTRANSFERASE-RXN				
rxn00421	>			[SW] Reaction irreversible according to BRENDA	https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.80#SUBSTRATE				
rxn02708	>			[SW] Strongly exergonic reaction. Most likely irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DTDP-GALACTOSE-6-DEHYDROGENASE-RXN				
rxn01243	>			[SW] Reaction reported irreversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=1.2.4.2#SUBSTRATE				
rxn11355	>			[SW] New direction according to Metacyc. Kinases are most commonly irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-8443				
rxn00018	>			[SW] irrev.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN # https://www.brenda-enzymes.org/enzyme.php?ecno=4.1.1.39#NATURAL%20SUBSTRATES				
rxn13403	>			[SW] ABC transportes usually cannot synthesize ATP.					
rxn13728	>			[SW] Reaction never reported to be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=1.6.99.3#SUBSTRATE				
rxn00023	>			[SW] Reaction never reported to be reversible. Irrev. According to MetaCyc	https://metacyc.org/META/substring-search?type=NIL&object=1.8.2.2&quickSearch=Quick+Search				
rxn13770	>			[SW] Reaction irreversible according to BRENDA and MetaCyc	http://www.brenda-enzymes.org/enzyme.php?ecno=1.6.3.1 # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-10745				
rxn13720	>			[SW] Reaction never reported to be reversible. Irrev. According to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN				
rxn13709	>			[SW] Reaction irreversible according to BRENDA and MetaCyc	http://www.brenda-enzymes.org/enzyme.php?ecno=1.1.5.3#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-15745				
rxn13691	>			[SW] Reaction irreversible according to BRENDA and MetaCyc	http://www.brenda-enzymes.org/enzyme.php?ecno=1.3.5.2#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-6554				
rxn13718	>			[SW] Reaction irreversible according to BRENDA and MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=D-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN # http://www.brenda-enzymes.org/enzyme.php?ecno=1.1.2.4#NATURAL%20SUBSTRATES				
rxn13753	>			[SW] Reaction irreversible according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=1.6.5.8#NATURAL%20SUBSTRATES				
rxn13732	>			[SW] Reaction irreversible according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=1.7.5.1#NATURAL%20SUBSTRATES				
rxn12293	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=D-2-HYDROXY-ACID-DEHYDROGENASE-RXN				
rxn13700	>			[SW] Reaction irreversible according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=1.2.2.3#SUBSTRATE				
rxn12295	>			[SW] Reaction irreversible according to BRENDA and MetaCyc	http://www.brenda-enzymes.org/enzyme.php?ecno=1.13.12.16 # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2-NITROPROPANE-DIOXYGENASE-RXN				
rxn12706	>			[SW] Reaction irreversible according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=1.13.11.8#NATURAL%20SUBSTRATES				
rxn12740	>			[SW] Reaction never reported to be reversible.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.1.99.3#SUBSTRATE				
rxn00568		TRUE		[SW] Reactions seems very odd & cannot be found in any Database.					
rxn12220	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-1461				
rxn13518	>			[SW] Reaction never reported to be reversible. Irrev. According to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=PHOSPHOLIPASE-C-RXN # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.4.3#NATURAL%20SUBSTRATES				
rxn13735	>			[SW] Reaction irreversible according to BRENDA and MetaCyc	http://www.brenda-enzymes.org/enzyme.php?ecno=1.7.2.2#SUBSTRATE # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-16564				
rxn13640	>			[SW] Reaction irreversible according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=1.2.2.3#SUBSTRATE				
rxn13895	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-14903				
rxn02149	>			[SW] Reaction irreversible according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.42#NATURAL%20SUBSTRATES				
rxn13927	>			[SW] Reaction never reported to be reversible.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.6.5.11#NATURAL%20SUBSTRATES				
rxn01107	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLUCONOLACT-RXN				
rxn10990	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-14107				
rxn12750	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-14107				
rxn12369		TRUE		[SW] "extraorganism-cytosol" compartment not needed.					
rxn12422		TRUE		[SW] "extraorganism-cytosol" compartment not needed.					
rxn12245	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc	https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.42#NATURAL%20SUBSTRATES				
rxn03970	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1241 # https://www.brenda-enzymes.org/enzyme.php?ecno=1.2.1.68#SUBSTRATE				
rxn03971	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1241 # https://www.brenda-enzymes.org/enzyme.php?ecno=1.2.1.68#SUBSTRATE				
rxn10902	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLU6PDEHYDROG-RXN # https://www.brenda-enzymes.org/enzyme.php?ecno=1.1.1.49#SUBSTRATE				
rxn12649	>			[SW] "equilibrium strongly favors tetrahydrofolate production"	Huennekens, F.M.; Vitols, K.S.; Whiteley, J.M.; Neef, V.G.; Methods Cancer Res. 13, 199-225 (1976)				
rxn14120	<			[SW] "equilibrium strongly favors tetrahydrofolate production"	Huennekens, F.M.; Vitols, K.S.; Whiteley, J.M.; Neef, V.G.; Methods Cancer Res. 13, 199-225 (1976)				
rxn01476	>			[SW] irrev.	Kupor, S.R.; Fraenkel, D.G.; J. Biol. Chem. 247, 1904-1910 (1972)				
rxn13906	>			[SW] Reaction never reported to be reversible. Irrev. According to Ref.	https://www.brenda-enzymes.org/enzyme.php?ecno=1.5.99.6#SUBSTRATE # https://books.google.de/books?id=HiL0BgAAQBAJ&pg=PA115&lpg=PA115&dq=spermidine+dehydrogenase+irreversible&source=bl&ots=ZZCxRcgy8V&sig=O2LkBTkU62eBop9NxjjsnmLPYoU&hl=de&sa=X&ved=0ahUKEwio8e-9p87ZAhUKlSwKHVWjD6QQ6AEIMzAB#v=onepage&q=spermidine%20dehydrogenase%20irreversible&f=false				
rxn13726	=		-1:cpd00004:0:0:"NADH";-5:cpd00067:0:0:"H+";-1:cpd15560:0:0:"Ubiquinone-8";1:cpd00003:0:0:"NAD";4:cpd00067:1:0:"H+";1:cpd15561:0:0:"Ubiquinol-8"	[SW] Reverse electron transport only in photosynthetic bacteria. [SW] Reversted to original direction and changing number of transporeted protons according to rxn08972	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=NADH-DEHYDROG-A-RXN				
rxn03275	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc	https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.17#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLUCONOLACT-RXN				
rxn02705	>			[SW] irrev.	Baiocco, P.; Poce, G.; Alfonso, S.; Cocozza, M.; Porretta, G.C.; Colotti, G.; Biava, M.; Moraca, F.; Botta, M.; Yardley, V.; Fiorillo, A.; Lantella, A.; Malatesta, F.; Ilari, A.; ChemMedChem 8, 1175-1183 (2013)				
rxn00443	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GALACTONOLACTONE-DEHYDROGENASE-RXN				
rxn00872	<			[SW] irreversible according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=BUTYRYL-COA-DEHYDROGENASE-RXN				
rxn03052	>			[SW] "(EC 2.1.1.14) catalyzes the irreversible methylation of homocysteine using a methyl derivative of tetrahydrofolate"	10.1371/journal.pone.0111108				
rxn09780		TRUE		[SW] Mitochondrium-specific reaction					
rxn01048	>			[SW] irrev.	Bystrykh, L.V.; Sokolov, A.P.; Trotsenko, Y.A.; FEBS Lett. 132, 324-328 (1981)				
rxn00745	>			[SW] never reported reversible according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.121#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.7.1.121-RXN				
rxn12217	>			[SW] spontaneous, and irreversible according to MetaCyc, irreversible (non-enzymatic reaction)	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-2881				
rxn04677	>			[SW] irrev.	Bystrykh, L.V.; Sokolov, A.P.; Trotsenko, Y.A.; FEBS Lett. 132, 324-328 (1981)				
rxn13496	>			[SW] irrev.	Hatter, K.; Sokatch, J.R.; Methods Enzymol. 166, 389-393 (1988)				
rxn03899	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-12900				
rxn04154	>			[SW] irrev according to ref.	Rzeznicka, K.; Walker, C.J.; Westergren, T.; Kannangara, C.G.; von Wettstein, D.; Merchant, S.; Gough, S.P.; Hansson, M.; Proc. Natl. Acad. Sci. USA 102, 5886-5891 (2005)				
rxn04948	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc. Srongly exergonic reaction.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DTDP-GALACTOSE-6-DEHYDROGENASE-RXN # http://www.brenda-enzymes.org/enzyme.php?ecno=1.1.1.186#SUBSTRATE				
rxn09179	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=PROTOPORGENOXI-RXN # http://www.brenda-enzymes.org/enzyme.php?ecno=1.3.3.4#SUBSTRATE				
rxn09296	>			[SW] irrev.					
rxn02304	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=PROTOPORGENOXI-RXN # http://www.brenda-enzymes.org/enzyme.php?ecno=1.3.3.4#SUBSTRATE				
rxn08913	>			[SW] irrev.					
rxn09941	>			[SW] irrev.					
rxn08912	>			[SW] irrev.					
rxn08354	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIMESULFREDUCT-RXN				
rxn13692	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIMESULFREDUCT-RXN				
rxn09313	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.7.2.3#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-5264				
rxn06078	>			[SW] unsure, but highly exergonic reaction and never reported reversible.	http://www.brenda-enzymes.org/enzyme.php?ecno=2.5.1.47#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ACSERLY-RXN				
rxn08356	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIMESULFREDUCT-RXN				
rxn13716	>			[SW] hydrogenase is uni-directional	10.1074/jbc.M109.067751				
rxn01862		TRUE		[SW] Tis reaction is not reported with FAD(H2) as cofactor.					
rxn08355	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.7.2.3#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-5264				
rxn09314	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.7.2.3#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-5264				
rxn12777	>			[SW] unsure, but highly exergonic reaction and never reported reversible.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.2.4.4#NATURAL%20SUBSTRATES				
rxn01639	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=FORMIMINOGLUTAMASE-RXN				
rxn05256	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-12019				
rxn05289	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=THIOREDOXIN-REDUCT-NADPH-RXN				
rxn08357	>			[SW] unsure. However, biosynthesis of DMSO unlikely, because its a xenobiotic.					
rxn09315	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-5264				
rxn09316	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-5264				
rxn12682		TRUE		[SW] Reaction cannot be found in any other database.					
rxn12054		TRUE		[SW] Reaction cannot be found in any other database.					
rxn03379	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc.	http://www.brenda-enzymes.org/enzyme.php?ecno=4.4.1.8#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-12729				
rxn00131	>			[SW] irrev according to ref.	Hurwitz, J.; Heppel, L.A.; Horecker, B.L.; J. Biol. Chem. 226, 525-540 (1957)				
rxn00736	<			[SW] irrev according to ref. Reverse direction only	http://www.brenda-enzymes.org/enzyme.php?ecno=1.1.1.38#SUBSTRATE				
rxn01226	>			[SW] irreversible accdording to several references. See BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=3.2.2.1#SUBSTRATE				
rxn14117	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLUCONATE-2-DEHYDROGENASE-RXN				
rxn14207	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.1.2.7#NATURAL%20SUBSTRATES # https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-2861				
rxn05748	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-3501				
rxn02260			-1:cpd00001:0:0:"H2O";-1:cpd03375:0:0:"3-Hydroxypropanoyl-CoA";1:cpd00010:0:0:"CoA";2:cpd00067:0:0:"H+";1:cpd00745:0:0:"Hydracrylic acid"	[SW] Reaction not coupled with ATP synthesis.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-13721				
rxn15275	>			[SW] unsure, but highly exergonic reaction and never reported reversible.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.1.2.2#SUBSTRATE				
rxn14369		TRUE		[SW] unspecified generic reaction.					
rxn14386		TRUE		[SW] unspecified generic reaction.					
rxn14317		TRUE		[SW] unspecified generic reaction.					
rxn14197		TRUE		[SW] unspecified generic reaction.					
rxn13519	>			[SW] irrev according to ref.	Mukai, T.; Kawai S.; Matsukawa, H.; Matuo, Y.; Murata, K.; Appl. Environ. Microbiol. 69, 3849-3857 (2003)				
rxn15018	>			[SW] irrev according to ref.	Hurwitz, J.; Heppel, L.A.; Horecker, B.L.; J. Biol. Chem. 226, 525-540 (1957)				
rxn15575	>			[SW] Cellulose hydrolase. Not rev. according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-10773				
rxn15557	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CELLULOSE-SYNTHASE-UDP-FORMING-RXN				
rxn14050	>			[SW] irrev according to several references. See BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=1.13.11.18#NATURAL%20SUBSTRATES				
rxn16131	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-10892				
rxn16093	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-8815				
rxn16103	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-8815				
rxn16092	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-8815				
rxn16102	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-8815				
rxn16097	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-8815				
rxn16105	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-8815				
rxn00569	<			[SW] Nitrite reductase (NAD(P)H) is irreversible and forms ammonium accdoring to several sources, including the E. coli model iJO1336.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-6377				
rxn15500	>			[SW] New direction according to Metacyc. Phosphatase is not reversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-12728				
rxn01348	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=6PFRUCTPHOS-RXN # http://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.11#SUBSTRATE				
rxn13333	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN # http://www.brenda-enzymes.org/enzyme.php?ecno=1.1.2.3#SUBSTRATE				
rxn13246	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN # http://www.brenda-enzymes.org/enzyme.php?ecno=1.1.2.3#SUBSTRATE				
rxn01346	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=6PFRUCTPHOS-RXN # http://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.11#SUBSTRATE				
rxn01347	>			[SW] never reported reversible according to BRENDA, and irreversible according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=6PFRUCTPHOS-RXN # http://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.11#SUBSTRATE				
rxn15962	>			[SW] Changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=ACETYLSYNCLTH-RXN&&detail-level=2				
rxn02476	=			[JZ][SW] Reaction direction was wrong. Should be reversible according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.5.1.19-RXN				
rxn02937	>			[JZ][SW] Reaction direction was wrong. Should be reversed according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=AIRS-RXN				
rxn12953	>			[JZ][SW] Reaction direction was wrong. Should be reversed according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=H2PTERIDINEPYROPHOSPHOKIN-RXN&detail-level=3				
rxn12361	>			[SW] RNA synthesis					
rxn12360	>			[SW] DNA synthesis					
rxn06724		TRUE		[SW] Reaction cannot be found in any other database & causes futile cycles. Probably also unbalanced					
rxn06761		TRUE		[SW] Reaction cannot be found in any other database & causes futile cycles. Probably also unbalanced					
rxn11023	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=R147-RXN				
rxn05091	>			[SW] New direction according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=1.13.11.53#NATURAL%20SUBSTRATES				
rxn05107	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.1.3.77-RXN				
rxn13961	>			[SW] New direction according to Metacyc	https://metacyc.org/META/substring-search?type=NIL&object=1.14.14.1				
rxn11956	<			[SW] New direction according to Metacyc	https://metacyc.org/META/substring-search?type=NIL&object=1.14.14.1				
rxn00796	>			[SW] New direction according to Metacyc. In my Opinion this reaction is not complete.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.8.1.6-RXN				
rxn06786		TRUE		[SW] Reaction cannot be found in any other database & causes futile cycles. Probably also unbalanced					
rxn03277		TRUE		[SW] Reaction cannot be found in any other database & causes futile cycles. Probably also unbalanced					
rxn06018		TRUE		[SW] generic reaction.					
rxn10043	>			[SW] Oxygen consuming reaction. Highly exergonic					
rxn14218		TRUE		[SW] generic reaction.					
rxn14234		TRUE		[SW] generic reaction.					
rxn12337		TRUE		[SW] generic reaction.					
rxn12338		TRUE		[SW] generic reaction.					
rxn12339		TRUE		[SW] generic reaction.					
rxn12341		TRUE		[SW] generic reaction.					
rxn12342		TRUE		[SW] generic reaction.					
rxn12343		TRUE		[SW] generic reaction.					
rxn12345		TRUE		[SW] generic reaction.					
rxn13047		TRUE		[SW] generic reaction.					
rxn13048		TRUE		[SW] generic reaction.					
rxn13049		TRUE		[SW] generic reaction.					
rxn13086		TRUE		[SW] generic reaction.					
rxn13093		TRUE		[SW] generic reaction.					
rxn13094		TRUE		[SW] generic reaction.					
rxn13095		TRUE		[SW] generic reaction.					
rxn12276	>			[SW] New direction according to Metacyc. Highly exergonic	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-7904				
rxn12321	>			[SW] New direction according to Metacyc. Highly exergonic	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9624				
rxn10964		TRUE		[SW] Model-specific reaction.					
rxn10992		TRUE		[SW] Model-specific reaction.					
rxn12271	>			[SW] New direction according to Metacyc. Highly exergonic	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-7904				
rxn12315	>			[SW] New direction according to Metacyc. Highly exergonic	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9624				
rxn11084		TRUE		[SW] Odd reactions causing futile cycles.					
rxn11177	>			[SW] New direction according to Metacyc. Exergonic	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=SAMDECARB-RXN				
rxn12180	>		-1:cpd00005:0:0:"NADPH";-2:cpd11795:0:0:"Ferricytochrome b5";1:cpd00006:0:0:"NADP";2:cpd11797:0:0:"Ferrocytochrome b5";1:cpd00067:0:0:"H+"	[SW] New direction according to Metacyc [SW] and balanced	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN				
rxn06324	>			[SW] Never reported reversible.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.10.2.1#NATURAL%20SUBSTRATES				
rxn14119		TRUE		[SW] Mammal-specific					
rxn06159		TRUE		[SW] Mammal-specific					
rxn11123	>								
rxn06782		TRUE		[SW] generic reaction.					
rxn06277		TRUE		[SW] generic reaction.					
rxn12328	>			[SW] New direction according to Metacyc (*-acp hydrolase)	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-7902				
rxn12327	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11474				
rxn12326	>			[SW] New direction according to Metacyc (*-acp reductase)	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3-OXOACYL-ACP-REDUCT-RXN				
rxn12324	>			[SW] New direction according to Metacyc (*-acp reductase)	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3-OXOACYL-ACP-REDUCT-RXN				
rxn12320	>			[SW] New direction according to Metacyc (*-acp hydrolase)	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-7902				
rxn12279	>			[SW] New direction according to Metacyc (acyl-acp dehydrogenase)	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=OHACYL-COA-DEHYDROG-RXN				
rxn12257	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=KETOACYLCOATHIOL-RXN				
rxn10800	>								
rxn16323	>			[SW] Unsure.					
rxn16207	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=SELENOCYSTEINE-LYASE-RXN				
rxn11633	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=THIOL-S-METHYLTRANSFERASE-RXN				
rxn02571	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-12726				
rxn11052		TRUE		[SW] Wrong metabolite.					
rxn11090		TRUE		[SW] Wrong metabolite.					
rxn12255		TRUE		[SW] Reactions cause Futile Cycles. Probably not balanced.					
rxn12256		TRUE		[SW] Reactions cause Futile Cycles. Probably not balanced.					
rxn15674		TRUE		[SW] Reactions cause Futile Cycles. Probably not balanced.					
rxn16336		TRUE		[SW] Reactions cause Futile Cycles. Probably not balanced.					
rxn03175	=			[SW] Isomerase. Should be reversible.					
rxn03137	=			[SW] Reversible according to Metacyc & BRENDA.	http://www.brenda-enzymes.org/enzyme.php?ecno=2.1.2.3#NATURAL%20SUBSTRATES				
rxn03135	=			[SW] Reversible according to Metacyc Histidine Biosynthesis Pathway.	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=HISTSYN-PWY				
rxn02504	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=H2NEOPTERINALDOL-RXN # 				
rxn01213	=			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=GPPSYN-RXN				
rxn09210	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-5669				
rxn09113	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=PHOSPHAGLYPSYN-RXN&detail-level=2				
rxn09225	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11807				
rxn03409	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLUTAMINESYN-RXN				
rxn00461	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN&detail-level=3				
rxn03538	=			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=COBALAMINSYN-RXN				
rxn13141	=			[SW] Reversible according to Metacyc & BRENDA.	http://www.brenda-enzymes.org/enzyme.php?ecno=3.5.99.6#SUBSTRATE # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLUCOSAMINE-6-P-DEAMIN-RXN				
rxn05331	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN1G-363				
rxn05329	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN1G-363				
rxn05334	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN1G-363				
rxn05462	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN1G-363				
rxn00438	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=THI-P-KIN-RXN				
rxn00437	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=THIAMIN-DIPHOSPHATE-KINASE-RXN				
rxn12219	>		-3:cpd00007:0:0:"O2";-1:cpd00791:0:0:"ProtoporphyrinogenIX";3:cpd00025:0:0:"H2O2";1:cpd01476:0:0:"Protoporphyrin"	[SW] Stoichiometry changed for charge balance according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=PROTOPORGENOXI-RXN				
rxn13893			-1:cpd00791:0:0:"ProtoporphyrinogenIX";-3:cpd15500:0:0:"Menaquinone 8";3:cpd15499:0:0:"Menaquinol 8";1:cpd01476:0:0:"Protoporphyrin"	[SW] Stoichiometry changed for charge balance according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-6259				
rxn04396		TRUE		[SW] Not needed for microbial reconstructions.					
rxn11670		TRUE		[SW] Not needed for microbial reconstructions.					
rxn04160	>		-2:cpd00001:0:0:"H2O";-2:cpd00002:0:0:"ATP";-2:cpd11620:0:0:"Reducedferredoxin";-1:cpd01845:0:0:"Protochlorophyllide";2:cpd00008:0:0:"ADP";2:cpd00009:0:0:"Phosphate";2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd01449:0:0:"Chlorophyllide"	[SW] Stoichiometry & rev. changed for charge balance according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11902				
rxn04397			-2:cpd00006:0:0:"NADP";-1:cpd06619:0:0:"(-)-Epicatechin";2:cpd00005:0:0:"NADPH";4:cpd00067:0:0:"H+";1:cpd03502:0:0:"IdB 1027"	[SW] Reaction completely wrong? Correct version stored in reaction rxn11671	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9725				
rxn04398			-2:cpd00006:0:0:"NADP";-1:cpd08918:0:0:"(-)-Epigallocatechin";2:cpd00005:0:0:"NADPH";4:cpd00067:0:0:"H+";1:cpd03505:0:0:"Ephdine"	[SW] Reaction completely wrong? Correct version stored in reaction rxn11672	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9723				
rxn04915	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=EC-NUMBER&object=EC-1.14.14.1				
rxn00645	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CYSTEINE-DIOXYGENASE-RXN				
rxn12866			-1:cpd00006:0:0:"NADP";-1:cpd00517:0:0:"1-Acyl-sn-glycerol 3-phosphate";1:cpd00005:0:0:"NADPH";2:cpd00067:0:0:"H+";1:cpd12300:0:0:"Acylglycerone phosphate"	[SW] Reaction completely wrong? Correct version stored in reaction rxn06233	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-17728				
rxn04881		TRUE		[SW] Reaction unbalanced and causes futile cycles.					
rxn10947		TRUE		[SW] Reaction unbalanced and causes futile cycles.					
rxn09180	>			[SW] New direction according to Metacyc (via EC)	https://metacyc.org/META/NEW-IMAGE?type=EC-NUMBER&object=EC-1.3.3.4				
rxn08088	>		-1:cpd00067:0:0:"H+";-1:cpd15268:0:0:"Octadecanoyl-ACP";-1:cpd15329:0:0:"1-octadecanoyl-sn-glycerol 3-phosphate";1:cpd11493:0:0:"ACP";1:cpd15526:0:0:"1,2-dioctadecanoyl-sn-glycerol 3-phosphate"	[SW] New direction according to Metacyc (via EC)	https://metacyc.org/META/NEW-IMAGE?type=EC-NUMBER&object=EC-2.3.1.51				
rxn00431			-1:cpd00001:0:0:"H2O";-1:cpd00187:0:0:"Methanamine";-2:cpd20919:0:0:"Amicyanin";1:cpd00013:0:0:"NH3";1:cpd00055:0:0:"Formaldehyde";2:cpd00067:0:0:"H+";2:cpd20920:0:0:"Reduced amicyanin"	[SW] Stoichiometry changed for charge balance according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-2841				
rxn00347	>			[SW] Reaction never reported to be reversible. Irrev. According to MetaCyc	http://www.brenda-enzymes.org/enzyme.php?ecno=3.5.1.1#NATURAL%20SUBSTRATES				
rxn08710	>		-1:cpd03587:0:0:"kdo2-lipid a";-1:cpd03831:0:0:"ADP-L-glycero-D-manno-heptose";1:cpd00008:0:0:"ADP";1:cpd15485:0:0:"heptosyl-kdo2-lipidA"	[SW] New direction according to Metacyc. Proton & charge balanced.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-5118				
rxn13150		TRUE		[SW] Reaction seems to be EC6.3.3.2. But is has wrong stoichiometry. CHECK THIS	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=5-FORMYL-THF-CYCLO-LIGASE-RXN				
rxn00970	>		-1:cpd00001:0:0:"H2O";-1:cpd00604:0:0:"4-Coumarate";1:cpd00029:0:0:"Acetate";1:cpd00484:0:0:"p-Hydroxybenzaldehyde"	[SW] Reaction not found in any database. Replace with reaction stoichiometry according to MetaCyc,	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-8871				
rxn08761		TRUE		[SW] Diffusion of large molecule? CHECK THIS					
rxn08244		TRUE		[SW] Diffusion of large molecule? CHECK THIS					
rxn12376		TRUE		[SW] Diffusion of large polar molecule? CHECK THIS?					
rxn11059		TRUE		[SW] generic reaction.					
rxn00462	=			[SW] Reversible according to Metacyc & BRENDA.	http://www.brenda-enzymes.org/enzyme.php?ecno=5.4.2.9#NATURAL%20SUBSTRATES				
rxn00640	=			[SW] Reversible according to Metacyc & BRENDA.	http://www.brenda-enzymes.org/enzyme.php?ecno=2.7.7.22#SUBSTRATE				
rxn00114	=			[SW] Reversible according to Metacyc & BRENDA.	http://www.brenda-enzymes.org/enzyme.php?ecno=2.7.2.2#SUBSTRATE				
rxn09447	>			[SW] Wrong reaction direction. Corrected.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-7904				
rxn09448	>			[SW] Wrong reaction direction. Corrected.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-7904				
rxn09450	>			[SW] Wrong reaction direction. Corrected.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-7904				
rxn02794	>			[SW] Wrong reaction direction. Corrected.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-17398				
rxn09458	>			[SW] Wrong reaction direction. Corrected.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.14.19.1-RXN				
rxn06882	>			[SW] Wrong reaction direction. Corrected.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=FOLYLPOLYGLUTAMATESYNTH-RXN				
rxn08294	>			[SW] Wrong reaction direction. Corrected.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIACYLGLYKIN-RXN				
rxn08295	>			[SW] Wrong reaction direction. Corrected.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIACYLGLYKIN-RXN				
rxn08296	>			[SW] Wrong reaction direction. Corrected.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIACYLGLYKIN-RXN				
rxn08297	>			[SW] Wrong reaction direction. Corrected.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIACYLGLYKIN-RXN				
rxn08298	>			[SW] Wrong reaction direction. Corrected.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIACYLGLYKIN-RXN				
rxn08299	>			[SW] Wrong reaction direction. Corrected.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIACYLGLYKIN-RXN				
rxn08300	>			[SW] Wrong reaction direction. Corrected.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIACYLGLYKIN-RXN				
rxn14185	>			[SW] Wrong reaction direction. Corrected.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.7.4.24-RXN				
rxn08086	>			[SW] Fatty acid elongation not reversible as such.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-16025				
rxn09459	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-15112				
rxn12994	>			[SW] Reversible according to Metacyc & BRENDA.	http://www.brenda-enzymes.org/enzyme.php?ecno=4.2.1.59#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=4.2.1.58-RXN				
rxn08808	>		-1:cpd00001:0:0:"H2O";-1:cpd15341:0:0:"2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:0)";1:cpd00908:0:0:"Glycerophosphoethanolamine";1:cpd01080:0:0:"ocdca";1:cpd00067:0:0:"H+"	[SW] Corrected with the saturated phospholipid	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-15035				
rxn09156	>		-1:cpd00001:0:0:"H2O";-1:cpd15533:0:0:"phosphatidylethanolamine dioctadecanoyl";1:cpd00067:0:0:"H+";1:cpd01080:0:0:"ocdca";1:cpd15341:0:0:"2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:0)"	[SW] Corrected with the saturated phospholipid					
rxn05813		TRUE		[SW] Unbalanced and generic reaction.					
rxn06015		TRUE		[SW] Unbalanced and generic reaction.					
rxn06016		TRUE		[SW] Unbalanced and generic reaction.					
rxn08801	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-15035				
rxn00946	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-16540				
rxn08053	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ACYLCOADEHYDROG-RXN				
rxn08204	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CDPDIGLYPYPHOSPHA-RXN				
rxn08700	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-17777				
rxn09460	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.14.99.31-RXN				
rxn20479	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=OHACYL-COA-DEHYDROG-RXN				
rxn20481	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=OHACYL-COA-DEHYDROG-RXN				
rxn23000	<			[SW] Reversible according to Metacyc & BRENDA.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.3.1.44#NATURAL%20SUBSTRATES				
rxn31439	>			[SW] Reversible according to Metacyc & BRENDA.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.3.8.7#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-13615				
rxn31441	>			[SW] Reversible according to Metacyc & BRENDA.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.3.8.7#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-13615				
rxn31450	>			[SW] Reversible according to Metacyc & BRENDA.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.3.8.7#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-13615				
rxn31451	>			[SW] Reversible according to Metacyc & BRENDA.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.3.8.7#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-13615				
rxn09499	=			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GCVP-RXN				
rxn08793	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN				
rxn08901	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=MALATE-DEHYDROGENASE-ACCEPTOR-RXN				
rxn08306	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CDPDIGLYSYN-RXN				
rxn08307	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CDPDIGLYSYN-RXN				
rxn08308	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CDPDIGLYSYN-RXN				
rxn08309	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CDPDIGLYSYN-RXN				
rxn08310	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CDPDIGLYSYN-RXN				
rxn08312	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CDPDIGLYSYN-RXN				
rxn12897	>			[SW] Irreversible according to Metacyc & BRENDA.	http://www.brenda-enzymes.org/enzyme.php?ecno=6.3.4.6#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=UREA-CARBOXYLASE-RXN				
rxn00562	>			[SW] Irreversible according to Metacyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=UREIDOGLYCOLATE-LYASE-RXN				
rxn00564	<			[SW] irrev according to ref.	http://www.brenda-enzymes.org/literature.php?e=4.2.1.69&r=33954				
rxn01162	>			[SW] Irreversible according to Metacyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=METHYLGUANIDINASE-RXN				
rxn01542	>			[SW] Irreversible according to Metacyc & BRENDA.	http://www.brenda-enzymes.org/enzyme.php?ecno=3.5.1.95#SUBSTRATE				
rxn03507	>			[SW] Irreversible according to Metacyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-13200				
rxn03508	>			[SW] Irreversible according to Metacyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-13199				
rxn06105	>			[SW] Irreversible according to Metacyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=BARBITURASE-RXN				
rxn10253	>			[SW] Kinase. Shoud be irreversible. Also according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIACYLGLYKIN-RXN				
rxn10254	>			[SW] Kinase. Shoud be irreversible. Also according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIACYLGLYKIN-RXN				
rxn10255	>			[SW] Kinase. Shoud be irreversible. Also according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIACYLGLYKIN-RXN				
rxn10256	>			[SW] Kinase. Shoud be irreversible. Also according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIACYLGLYKIN-RXN				
rxn10257	>			[SW] Kinase. Shoud be irreversible. Also according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIACYLGLYKIN-RXN				
rxn10258	>			[SW] Kinase. Shoud be irreversible. Also according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIACYLGLYKIN-RXN				
rxn05928			-1:cpd00001:0:0:"H2O";-1:cpd00006:0:0:"NADP";-1:cpd00105:0:0:"D-Ribose";1:cpd00005:0:0:"NADPH";2:cpd00067:0:0:"H+";1:cpd11932:0:0:"D-Ribonate"	[SW] Stoichiometry corrected according to RHEA DB.	https://www.rhea-db.org/reaction?id=11676				
rxn13985	<			[SW] New direction according to Metacyc. And works in the direction of NADP reduction to NADPH.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.1.1.135-RXN				
rxn06872	<		-1:cpd00005:0:0:"NADPH";-2:cpd00017:0:0:"S-Adenosyl-L-methionine";-1:cpd00067:0:0:"H+";-2:cpd12872:0:0:"[Methionine synthase]-cob(I)alamin";1:cpd00006:0:0:"NADP";2:cpd00019:0:0:"S-Adenosyl-homocysteine";2:cpd12873:0:0:"[Methionine synthase]-methylcob(I)alamin"	[SW] works in the direction of NADP reduction to NADPH.  Stoich. Was also incorrect.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.1.1.135-RXN				
rxn13842		TRUE		[SW] Enzyme/Proton Pump only exists in the mucus in stomachs of mamals. Not reported for Microorganisms.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.6.3.10-RXN				
rxn00082	>		-1:cpd00005:0:0:"NADPH";-2:cpd00007:0:0:"O2";-2:cpd03527:0:0:"N-(omega)-Hydroxyarginine";2:cpd00001:0:0:"H2O";1:cpd00006:0:0:"NADP";1:cpd00067:0:0:"H+";2:cpd00274:0:0:"Citrulline";2:cpd00418:0:0:"NO"	[SW] Stoichiometry and reversibility corrected according to RHEA DB.	https://www.rhea-db.org/reaction?id=24664				
rxn05126	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-3922				
rxn05127	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-3922				
rxn06413		TRUE		[SW] Reaction incorrect. It should be benzyl alcohol and not p-cresol (different sum formula)	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=TOLUENE-SIDE-CHAIN-MONOOXYGENASE-RXN				
rxn10123	>			[SW] Direction and stoichiomentry changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=NADH-DEHYDROG-A-RXN				
rxn10124	>			[SW] Direction and stoichiomentry changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=NADH-DEHYDROG-A-RXN				
rxn08978	>			[SW] direction changed according to MetaCyc and rxn08977	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-271				
rxn08656	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-7229				
rxn08657	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-7229				
rxn08557	>			[SW] direction changed according to MetaCyc and rxn08556	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-15740				
rxn01861	<			[SW] No reference found that reports the oxidation of trimethylamine to trimethyl-N-oxide. Only for the opposite reaction.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.6.6.9				
rxn07893	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=BENZOATE-12-DIOXYGENASE-RXN				
rxn07892	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=BENZOATE-12-DIOXYGENASE-RXN				
rxn07896	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=BENZOATE-12-DIOXYGENASE-RXN				
rxn07897	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=BENZOATE-12-DIOXYGENASE-RXN				
rxn07898	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=BENZOATE-12-DIOXYGENASE-RXN				
rxn07889	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=BENZOATE-12-DIOXYGENASE-RXN				
rxn07890	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=BENZOATE-12-DIOXYGENASE-RXN				
rxn07902	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CATECHOL-12-DIOXYGENASE-RXN				
rxn07903	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CATECHOL-12-DIOXYGENASE-RXN				
rxn01785	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CYSTEAMINE-DIOXYGENASE-RXN				
rxn09997		TRUE		[SW] Reaction cannot be found in any other database.					
rxn13786	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-6381				
rxn06134	>		-1:cpd00007:0:0:"O2";-2:cpd00067:0:0:"H+";-1:cpd00327:0:0:"strcoa";-2:cpd11797:0:0:"Ferrocytochrome b5";2:cpd00001:0:0:"H2O";1:cpd00399:0:0:"Oleoyl-CoA";2:cpd11795:0:0:"Ferricytochrome b5"	[SW] direction and stoichiometry changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.14.19.1-RXN				
rxn09486	>			[SW] Probably irreversible because its a highly exergonic reaction.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.7.7.64-RXN				
rxn06754		TRUE		[SW] Reactions unbalanced in C and N					
rxn06755		TRUE		[SW] Reactions unbalanced in C and N					
rxn13163		TRUE		[SW] Model-specific reaction.					
rxn13164		TRUE		[SW] Model-specific reaction.					
rxn13165		TRUE		[SW] Model-specific reaction.					
rxn07295		TRUE		[SW] Charge unbalanced reaction . Also Cannot be found in any other DB.					
rxn07296		TRUE		[SW] Reactions unbalanced in C and N					
rxn07297		TRUE		[SW] Reactions unbalanced in C and N					
rxn11956		TRUE		[SW] generic reaction.					
rxn12190		TRUE		[SW] generic reaction.					
rxn11242	>			[SW] Backwards direction not possible because it would generate high energy phosphate bonds without utilizing any energy source.					
rxn11247	>			[SW] Backwards direction not possible because it would generate high energy phosphate bonds without utilizing any energy source.					
rxn11576		TRUE		[SW] generic reaction.					
rxn06504		TRUE		[SW] generic reaction.					
rxn05853		TRUE		[SW] generic reaction.					
rxn05879		TRUE		[SW] generic reaction.					
rxn14071		TRUE		[SW] generic reaction.					
rxn07190		TRUE		[SW] generic reaction.					
rxn13025		TRUE		[SW] Reaction unbalanced in P					
rxn11035			-1:cpd00067:0:0:"H+";-1:cpd00015:0:0:"FAD";-1:cpd00760:0:0:"2-Methylbutyryl-CoA";1:cpd00982:0:0:"FADH2";1:cpd16123:0:0:"tigyl-CoA"	[SW] Stoichiometry was adjusted according to imilar/same, but balanced reaction rxn02270					
rxn12323	>		-1:cpd00001:0:0:"H2O";-1:cpd16629:0:0:"octadenoyl-acp";1:cpd01080:0:0:"ocdca";1:cpd11493:0:0:"ACP";1:cpd00067:0:0:"H+"	[SW] Reversibility & stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9548				
rxn12937	>		-1:cpd00001:0:0:"H2O";-1:cpd12458:0:0:"Stearoyl-[acyl-carrier protein]";1:cpd00067:0:0:"H+";1:cpd01080:0:0:"ocdca";1:cpd11493:0:0:"ACP"	[SW] Reversibility changed according to MetaCyc. And replace cpd16828 with cpd12458	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9548				
rxn13027			-1:cpd00044:0:0:"3-phosphoadenylylsulfate";-1:cpd16831:0:0:"thioredoxin-dithiol";1:cpd00045:0:0:"Adenosine 3-5-bisphosphate";1:cpd00081:0:0:"Sulfite";1:cpd11420:0:0:"trdox";1:cpd00067:0:0:"H+"						
rxn14168	>		-1:cpd00001:0:0:"H2O";-1:cpd12024:0:0:"(S)-2-Haloacid";1:cpd11844:0:0:"HX";1:cpd12147:0:0:"(S)-2-Hydroxyacid";1:cpd00067:0:0:"H+"	[SW] Reversibility & stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2-HALOACID-DEHALOGENASE-RXN				
rxn14230	>		-1:cpd00001:0:0:"H2O";-1:cpd12024:0:0:"(S)-2-Haloacid";1:cpd11844:0:0:"HX";1:cpd12118:0:0:"(R)-2-Hydroxyacid";1:cpd00067:0:0:"H+"	[SW] Reversibility & stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2-HALOACID-DEHALOGENASE-RXN				
rxn14116	>		-1:cpd00001:0:0:"H2O";-1:cpd14489:0:0:"(R)-2-Haloacid";1:cpd11844:0:0:"HX";1:cpd12147:0:0:"(S)-2-Hydroxyacid";1:cpd00067:0:0:"H+"	[SW] Reversibility & stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2-HALOACID-DEHALOGENASE-RXN				
rxn14240	>		-1:cpd00001:0:0:"H2O";-1:cpd14489:0:0:"(R)-2-Haloacid";1:cpd11844:0:0:"HX";1:cpd12118:0:0:"(R)-2-Hydroxyacid";1:cpd00067:0:0:"H+"	[SW] Reversibility & stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2-HALOACID-DEHALOGENASE-RXN				
rxn12941	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3-OXOACYL-ACP-REDUCT-RXN				
rxn12942	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3-OXOACYL-ACP-REDUCT-RXN				
rxn12943	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3-OXOACYL-ACP-REDUCT-RXN				
rxn12944	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3-OXOACYL-ACP-REDUCT-RXN				
rxn12938	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3-OXOACYL-ACP-REDUCT-RXN				
rxn12939	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3-OXOACYL-ACP-REDUCT-RXN				
rxn13017	>		-1:cpd00001:0:0:"H2O";-1:cpd16811:0:0:"inositol-phosphoryl-D-ceramide";1:cpd00167:0:0:"Ceramide";1:cpd02484:0:0:"Inositol 3-phosphate";1:cpd00067:0:0:"H+"	[SW] Reversibility & stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=SPHINGOMYELIN-PHOSPHODIESTERASE-RXN				
rxn13018	>		-1:cpd00001:0:0:"H2O";-1:cpd16812:0:0:"inositol-phosphoryl-P-ceramide";1:cpd02484:0:0:"Inositol 3-phosphate";1:cpd08927:0:0:"Ceramide II";1:cpd00067:0:0:"H+"	[SW] Reversibility & stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=SPHINGOMYELIN-PHOSPHODIESTERASE-RXN				
rxn11031	>		-1:cpd00067:0:0:"H+";-1:cpd00005:0:0:"NADPH";-1:cpd00668:0:0:"ALCTT";1:cpd00006:0:0:"NADP";1:cpd16120:0:0:"2,3-dihydroxy-3-isovalerate"	[SW] Reversibility & stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ACETOLACTREDUCTOISOM-RXN				
rxn13098			-1:cpd00067:0:0:"H+";-1:cpd00005:0:0:"NADPH";-1:cpd11420:0:0:"trdox";1:cpd00006:0:0:"NADP";1:cpd16831:0:0:"thioredoxin-dithiol"	[SW] Stoichiometry changed for charge/H+ balance according to MetaCyc.	https://metacyc.org/compound?orgid=META&id=NADPH				
rxn13078	>		-1:cpd00008:0:0:"ADP";-1:cpd16831:0:0:"thioredoxin-dithiol";1:cpd00177:0:0:"dADP";1:cpd11420:0:0:"trdox";1:cpd00001:0:0:"H2O"	[SW] Reversibility & stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ADPREDUCT-RXN				
rxn13135	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ADPREDUCT-RXN				
rxn13079	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ADPREDUCT-RXN				
rxn13080	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ADPREDUCT-RXN				
rxn13081	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ADPREDUCT-RXN				
rxn13136	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ADPREDUCT-RXN				
rxn13137	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ADPREDUCT-RXN				
rxn13138	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ADPREDUCT-RXN				
rxn11047	>		-1:cpd00001:0:0:"H2O";-1:cpd00022:0:0:"Acetyl-CoA";-1:cpd02465:0:0:"tetrahydrodipicolinate";1:cpd00010:0:0:"CoA";1:cpd16133:0:0:"N-acetyl-L-2-amino-6-oxopimelase"	[SW] Reversibility & stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.3.1.89-RXN				
rxn11155	>			[SW] direction changed according to MetaCyc	https://metacyc.org/compound?orgid=META&id=N-ACETYL-L-2-AMINO-6-OXO-PIMELATE#tab=RXNS				
rxn12314			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd16608:0:0:"cis-dodec-3-enoyl-acp";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd16614:0:0:"cis-3-oxotetradec-4-enoyl-acp"	[SW] Stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.3.1.41-RXN				
rxn12319			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd16616:0:0:"cis-tetradec-4-enoyl-acp";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd16623:0:0:"cis-3-oxohexadec-7-enoyl-acp"	[SW] Stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.3.1.41-RXN				
rxn12327			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd16625:0:0:"cis-hexadec-7-enoyl-acp";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd16634:0:0:"cis-3-oxooctadec-9-enoyl-acp"	[SW] Stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.3.1.41-RXN				
rxn12311	>		-1:cpd00067:0:0:"H+";-1:cpd00004:0:0:"NADH";-1:cpd16610:0:0:"trans,cis-tetradec-2,4-enoyl-acp";1:cpd00003:0:0:"NAD";1:cpd16616:0:0:"cis-tetradec-4-enoyl-acp"	[SW] Reversibility & stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9662				
rxn12313	>		-1:cpd00067:0:0:"H+";-1:cpd00005:0:0:"NADPH";-1:cpd16614:0:0:"cis-3-oxotetradec-4-enoyl-acp";1:cpd00006:0:0:"NADP";1:cpd16612:0:0:"cis-3-hydroxytetradec-4-enoyl-acp"	[SW] Reversibility & stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9662				
rxn12316	>		-1:cpd00067:0:0:"H+";-1:cpd00004:0:0:"NADH";-1:cpd16619:0:0:"trans,cis-hexadec-2,7-enoyl-acp";1:cpd00003:0:0:"NAD";1:cpd16625:0:0:"cis-hexadec-7-enoyl-acp"	[SW] Reversibility & stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9662				
rxn12318	>		-1:cpd00067:0:0:"H+";-1:cpd00005:0:0:"NADPH";-1:cpd16623:0:0:"cis-3-oxohexadec-7-enoyl-acp";1:cpd00006:0:0:"NADP";1:cpd16621:0:0:"cis-3-hydroxyhexadec-7-enoyl-acp"	[SW] Reversibility & stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9662				
rxn12324	>		-1:cpd00067:0:0:"H+";-1:cpd00004:0:0:"NADH";-1:cpd16630:0:0:"trans,cis-octadec-2,9-enoyl-acp";1:cpd00003:0:0:"NAD";1:cpd16636:0:0:"cis-octadec-9-enoyl-acp"	[SW] Reversibility & stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9662				
rxn12326	>		-1:cpd00067:0:0:"H+";-1:cpd00005:0:0:"NADPH";-1:cpd16634:0:0:"cis-3-oxooctadec-9-enoyl-acp";1:cpd00006:0:0:"NADP";1:cpd16632:0:0:"cis-3-hydroxyoctadec-9-enoyl-acp"	[SW] Reversibility & stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9662				
rxn12900	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9543				
rxn12901	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9543				
rxn12902	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9543				
rxn12903	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9543				
rxn12904	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9543				
rxn12905	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9543				
rxn12906	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9543				
rxn12923	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ACYLCOASYN-RXN				
rxn12924	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ACYLCOASYN-RXN				
rxn12925	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ACYLCOASYN-RXN				
rxn12926	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ACYLCOASYN-RXN				
rxn22373	>			[SW] Reaction oxidises Fe2+ to Fe3+	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-12075				
rxn00056	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-1483				
rxn00905	<			[SW] Formation of formaldehyde not detected according to BRENDA.	http://www.brenda-enzymes.org/enzyme.php?ecno=4.1.2.12#SUBSTRATE				
rxn08336	>			[SW] direction changed according to MetaCyc and BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=1.3.5.2#NATURAL%20SUBSTRATES # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-6554				
rxn01484	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=NAG6PDEACET-RXN				
rxn08167	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=L-ASPARTATE-OXID-RXN				
rxn05210	=		-1:cpd00009:1:0:"Phosphate";-2:cpd00971:1:0:"Na+";1:cpd00009:0:0:"Phosphate";2:cpd00971:0:0:"Na+"	[SW] Stoichiometry of Pi/Na+ Symporter adjusted according to TCDB	http://www.tcdb.org/search/result.php?tc=2.A.58				
rxn34397			-1:cpd00009:1:0:"Phosphate";-2:cpd00971:1:0:"Na+";1:cpd00009:0:0:"Phosphate";2:cpd00971:0:0:"Na+"	[SW] Stoichiometry of Pi/Na+ Symporter adjusted according to TCDB	http://www.tcdb.org/search/result.php?tc=2.A.58				
rxn05313			-1:cpd00009:1:0:"Phosphate";-2:cpd00971:1:0:"Na+";1:cpd00009:0:0:"Phosphate";2:cpd00971:0:0:"Na+"	[SW] Stoichiometry of Pi/Na+ Symporter adjusted according to TCDB	http://www.tcdb.org/search/result.php?tc=2.A.58				
rxn34522			-1:cpd00009:1:0:"Phosphate";-2:cpd00971:1:0:"Na+";1:cpd00009:0:0:"Phosphate";2:cpd00971:0:0:"Na+"	[SW] Stoichiometry of Pi/Na+ Symporter adjusted according to TCDB	http://www.tcdb.org/search/result.php?tc=2.A.58				
rxn13118		TRUE		[SW] Transport not found in any other database and caused futile cycles.					
rxn09739		TRUE		[SW] Transport not found in any other database and caused futile cycles.					
rxn13120		TRUE		[SW] Odd transport reaction of water and glutamate.					
rxn06448	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=TRYPTOPHAN--TRNA-LIGASE-RXN				
rxn13170	>		-1:cpd00002:0:0:"ATP";-1:cpd00065:0:0:"L-Tryptophan";-1:cpd11923:0:0:"tRNA(Trp)";1:cpd00012:0:0:"PPi";1:cpd00018:0:0:"AMP";1:cpd00067:0:0:"H+";1:cpd12336:0:0:"L-Tryptophanyl-tRNA(Trp)"	[SW] Trp was extracellular. Should be intracellular in this reaction. Direction also changed according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=TRYPTOPHAN--TRNA-LIGASE-RXN				
rxn08188			-1:cpd00063:0:0:"Ca2+";-3:cpd00971:1:0:"Na+";1:cpd00063:1:0:"Ca2+";3:cpd00971:0:0:"Na+"	[SW] Stoichiometry changed according to TCDB. 1:3	http://www.tcdb.org/search/result.php?tc=2.A.19				
rxn10868		TRUE		[SW] seems to be present only in mamalian kidney					
rxn05517		TRUE		[SW] Transporter not found in any other database.					
rxn08767	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-17787				
rxn01602	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-18357				
rxn04945	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLUCOSE-1-DEHYDROGENASE-NADP%2b-RXN				
rxn13834	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLUCOSE-1-DEHYDROGENASE-NADP%2b-RXN				
rxn00611	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.1.1.8-RXN				
rxn00612	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.1.1.8-RXN				
rxn00613	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.1.1.8-RXN				
rxn14229	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-15745				
rxn07251	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=NQOR-RXN				
rxn14299	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIHYDROOROTATE-DEHYDROGENASE-RXN				
rxn16165	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.1.99.25-RXN				
rxn20655		TRUE		[SW] Reaction is duplicate to rxn00151					
									
rxn00641	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.7.7.13-RXN				
rxn00649	>			[SW] Unsure but seems unlikely to be reversible as reaction is highly exergonic.					
rxn05733	>			[SW] Unsure but seems unlikely to be reversible as reaction is highly exergonic.					
rxn00952	>			[SW] Unsure but seems unlikely to be reversible as reaction is highly exergonic.					
rxn02229	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=MERCAPYSTRANS-RXN				
rxn02248	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.5.1.51-RXN				
rxn12991	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ACETYL-COA-CARBOXYLTRANSFER-RXN				
rxn13752			-2:cpd00067:0:0:"H+";-1:cpd01414:1:0:"Tetrathionate";-1:cpd17026:1:0:"methymenaquinol 7";2:cpd00067:1:0:"H+";2:cpd00268:1:0:"H2S2O3";1:cpd11606:0:0:"Menaquinone 7"	[SW] Stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-8358				
rxn05595			-1:cpd00067:0:0:"H+";-1:cpd00205:1:0:"K+";1:cpd00067:1:0:"H+";1:cpd00205:0:0:"K+"	[SW] K+/H+ transport should be antagonistic. Antiport.					
rxn10115	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=FORMATEDEHYDROG-RXN				
rxn16356									TRUE
rxn23236									TRUE
rxn05295		TRUE		[SW] non-required mRNA synthesis reactions					
rxn12361		TRUE		[SW] non-required mRNA synthesis reactions					
rxn00991	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN				
rxn02889	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=METHYLCROTONYL-COA-CARBOXYLASE-RXN				
rxn02866	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-2301				
									
rxn09722		TRUE		[SW] Mitochondrium-specific reaction					
rxn09750		TRUE		[SW] Mitochondrium-specific reaction					
rxn05315		TRUE		[SW] Unsure, but transport causes Zn2+/K+/H+ futile cycle. Also transport reaction not found in any other database.					
rxn12500	>			[SW] Unsure as not found in any other database. However, exergonic reaction.					
rxn08756	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-884				
rxn00272	>			[SW] irrev according to BRENDA (numerous studies)	http://www.brenda-enzymes.org/enzyme.php?ecno=2.6.1.44#NATURAL%20SUBSTRATES				
rxn01299	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-363				
rxn00868	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-12558				
rxn02283	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLUTAMATE-FORMIMINOTRANSFERASE-RXN				
rxn00364	>			[SW] never reported reversible according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=2.7.4.14#NATURAL%20SUBSTRATES				
rxn03365	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-8756				
rxn00474	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-2382				
rxn00471	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ORNITHINE-CYCLODEAMINASE-RXN				
rxn02516	>			[SW] never reported reversible according to BRENDA. Even reported IR in some cases.	http://www.brenda-enzymes.org/enzyme.php?ecno=4.4.1.9#NATURAL%20SUBSTRATES				
rxn01964	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=TRYPSYN-RXN				
rxn01023	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CYANIDE-HYDRATASE-RXN				
rxn00288	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=SUCCINATE-DEHYDROGENASE-UBIQUINONE6-RXN				
rxn00673	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=PROPCOASYN-RXN				
rxn00693	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=HOMOCYSMETB12-RXN				
rxn00909		TRUE		[SW] wrong electron carrier	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.5.1.20-RXN				
rxn00410	>			[SW] never reported reversible according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=6.3.4.2#SUBSTRATE				
rxn00859	>			[SW] never reported reversible according to BRENDA. Even reported IR in some cases.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.1.1.23#SUBSTRATE				
rxn00863	>			[SW] never reported reversible according to BRENDA. Even reported IR in some cases.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.1.1.23#SUBSTRATE				
rxn01280	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=TSA-REDUCT-RXN				
rxn01281	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=TSA-REDUCT-RXN				
rxn01301	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=HOMOSERDEHYDROG-RXN				
rxn01302	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=HOMOSERDEHYDROG-RXN				
rxn00927	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=PURINE-NUCLEOSIDASE-RXN				
rxn01649	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=XANTHOSINEPHOSPHORY-RXN				
rxn02186	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ACETOLACTREDUCTOISOM-RXN				
									
rxn01454	<			[SW] never reported reversible according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=2.3.3.10#NATURAL%20SUBSTRATES				
rxn13429	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-12558				
rxn05759	>			[SW] Changed according to MetaCyc & BRENDA. [SW+JZ] update, made only forward as otherwise its causing futile cycles (backwards reaction needs chemiosmotic coupling see rxn90057)	http://www.brenda-enzymes.org/enzyme.php?ecno=1.12.7.2#NATURAL%20SUBSTRATES http://dx.doi.org/10.1038/nrmicro1931				
rxn05142	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-8014				
rxn01867	>			[SW] Reaction highly exergonic.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=BADH-RXN				
rxn10770	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-6021				
rxn01459	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=AMINOBUTDEHYDROG-RXN				
rxn01851	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=AMINOBUTDEHYDROG-RXN				
rxn16141	<			[JZ] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-11002				
rxn00085	<			[SW] Most commonly found irreversible	http://www.brenda-enzymes.org/enzyme.php?ecno=1.4.1.13#NATURAL%20SUBSTRATES				
rxn03005	=		-1:cpd00201:0:0:"10-Formyltetrahydrofolate";-1:cpd02394:0:0:"GAR";1:cpd00067:0:0:"H+";1:cpd00087:0:0:"Tetrahydrofolate";1:cpd02678:0:0:"N-Formyl-GAR"	[SW] 5-10 THF is wrong reactant here. Should be 10-THF	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GART-RXN				
rxn03004	=			[SW] Rev. according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GART-RXN				
rxn00542		TRUE		[SW] Reaction only reported only once in rat liver in a 1978 publication, that is not available online.	https://www.ncbi.nlm.nih.gov/pubmed/3629727				
rxn01452	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3-HYDROXYBUTYRYL-COA-DEHYDROGENASE-RXN				
rxn03861	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3-HYDROXYBUTYRYL-COA-DEHYDROGENASE-RXN				
rxn01453	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-5901				
rxn06937	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLURS-RXN				
rxn06591	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLUTRNAREDUCT-RXN				
rxn13689	>		-2:cpd00109:0:0:"Cytochrome c3+";-1:cpd15561:0:0:"Ubiquinol-8";2:cpd00067:1:0:"H+";2:cpd00110:0:0:"Cytochrome c2+";1:cpd15560:0:0:"Ubiquinone-8"	[SW] direction and stoichiometry changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-18580				
rxn01644	>		-1:cpd00020:0:0:"Pyruvate";-1:cpd00346:0:0:"L-Aspartate4-semialdehyde";1:cpd00001:0:0:"H2O";1:cpd00067:0:0:"H+";1:cpd21488:0:0:"(2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate"	[SW] Reaction stoichiometry was corrected by the enzyme commission in 2012.	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=DIHYDRODIPICSYN-RXN				
rxn02928	<		-1:cpd00003:0:0:"NAD";-1:cpd02465:0:0:"tetrahydrodipicolinate";-1:cpd00001:0:0:"H2O";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd21488:0:0:"(2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate"	[SW] Reaction stoichiometry was corrected by the enzyme commission in 2012.	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-14014				
rxn02929	<		-1:cpd00006:0:0:"NADP";-1:cpd02465:0:0:"tetrahydrodipicolinate";-1:cpd00001:0:0:"H2O";1:cpd00005:0:0:"NADPH";1:cpd00067:0:0:"H+";1:cpd21488:0:0:"(2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate"	[SW] Reaction stoichiometry was corrected by the enzyme commission in 2012.	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-14014				
rxn25797	>			[SW] Reaction might be important for sulfur metabolism.	https://metacyc.org/META/NEW-IMAGE?type=NIL&object=RXN-9739&redirect=T				
rxn20818	>		-1:cpd00001:0:0:"H2O";-1:cpd00003:0:0:"NAD";-1:cpd17159:0:0:"2-Amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd00699:0:0:"5-Dehydroquinate";1:cpd00013:0:0:"Ammonium"	[SW] Reaction might be important for quinate metabolism.	https://metacyc.org/META/NEW-IMAGE?type=NIL&object=RXN-10032&redirect=T				
rxn20643	>			[SW] Important reaction for de novo thiamine biosynthesis	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=PYRIMSYN1-RXN				
rxn27289	>			[SW] Reaction important for Thiamin biosynthesis	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=THIAZOLSYN2-RXN&detail-level=3				
rxn25839	>			[SW] Reaction important for Thiamin biosynthesis	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-6892&detail-level=3				
rxn25838	>		-1:cpd22312:0:0:"Adenylated-ThiS-Proteins";-1:cpd28256:0:0:"ThiI-S-sulfanylcysteine";-2:cpd11620:0:0:"Reducedferredoxin";1:cpd00018:0:0:"AMP";1:cpd28255:0:0:"ThiI-L-cysteine";1:cpd28259:0:0:"Thiocarboxyadenylated-ThiS-Proteins";2:cpd11621:0:0:"Oxidizedferredoxin"	[SW] Reaction important for Thiamin biosynthesis. Plus corrected according to metacyc and charge balanced.	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-6892&detail-level=3				
rxn25837	>			[SW] Reaction important for Thiamin biosynthesis	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-6892&detail-level=3				
rxn05927	>		-2:cpd11620:0:0:"Reducedferredoxin";-2:cpd00017:0:0:"S-Adenosyl-L-methionine";-1:cpd00074:0:0:"S";-1:cpd01311:0:0:"Dethiobiotin";2:cpd00060:0:0:"L-Methionine";1:cpd00104:0:0:"BIOT";2:cpd03091:0:0:"5'-Deoxyadenosine";2:cpd11621:0:0:"Oxidizedferredoxin"	[SW] Reaction stoichiometry changed according to MetaCyc and RHEA	https://www.rhea-db.org/reaction?id=22060 # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.8.1.6-RXN				
rxn09310		TRUE		[SW] Incorrectly summarized reaction according to metacyc.	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-6891				
rxn00796		TRUE		[SW] Stoichiometry incorrect. Correct corresponding reaction: rxn05927	https://www.rhea-db.org/reaction?id=22060 # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.8.1.6-RXN				
rxn08180		TRUE		[SW] Stoichiometry incorrect. Correct corresponding reaction: rxn05927	https://www.rhea-db.org/reaction?id=22060 # https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.8.1.6-RXN				
rxn02931	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN				
rxn04790	>			[SW] direction changed according to Reference.	doi: 10.1099/mic.0.26795-0 				
rxn01361	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=OROTATE-REDUCTASE-NADH-RXN				
rxn09483			-1:cpd00015:0:0:"FAD";-1:cpd00041:0:0:"L-Aspartate";1:cpd00982:0:0:"FADH2";1:cpd03470:0:0:"Iminoaspartate"	[SW] Corrected metabolite compartments.					
rxn00548				[SW] Previous abbreviation referred to wrong KEGG identifier and caused wrong assignment to ec-number 4.1.2.9			F6p-p-ketolase		
rxn15060				[SW] Previous abbreviation referred to wrong KEGG identifier and caused wrong assignment to ec-number 4.1.2.9			F6p-p-ketolase		
rxn00782	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.2.1.13-RXN				
rxn02424	>		-1:cpd00001:0:0:"H2O";-1:cpd00003:0:0:"NAD";-1:cpd00010:0:0:"CoA";-1:cpd00287:0:0:"3-Oxo-2-methylpropanoate";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd00086:0:0:"Propionyl-CoA";1:cpd00242:0:0:"H2CO3"	[SW] Reaction equation changes according to MetaCyc and RHEA	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.2.1.27-RXN				
rxn12822	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLUTAMATE-SYNTHASE-FERREDOXIN-RXN				
rxn00928	<			[SW] direction changed according to MetaCyc	https://ecocyc.org/ECOLI/NEW-IMAGE?type=REACTION&object=PYRROLINECARBREDUCT-RXN				
rxn00929	<			[SW] direction changed according to MetaCyc	https://ecocyc.org/ECOLI/NEW-IMAGE?type=REACTION&object=PYRROLINECARBREDUCT-RXN				
rxn00930	<			[SW] direction changed according to MetaCyc	https://ecocyc.org/ECOLI/NEW-IMAGE?type=REACTION&object=PYRROLINECARBREDUCT-RXN				
rxn00931	<			[SW] direction changed according to MetaCyc	https://ecocyc.org/ECOLI/NEW-IMAGE?type=REACTION&object=PYRROLINECARBREDUCT-RXN				
rxn03910	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=NIL&object=RXN0-302&redirect=T				
rxn00541	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=NIL&object=THREONINE-ALDOLASE-RXN&redirect=T				
rxn01068	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=NIL&object=THREODEHYD-RXN&redirect=T				
rxn15090		TRUE		[SW] Literature on existence of this reaction is inconclusive.					
rxn15091		TRUE		[SW] Literature on existence of this reaction is inconclusive.					
rxn05981		TRUE		[SW] generic reaction.					
rxn05982		TRUE		[SW] generic reaction.					
rxn05983		TRUE		[SW] generic reaction.					
rxn05984		TRUE		[SW] generic reaction.					
rxn06022	>		-1:cpd00001:0:0:"H2O";-1:cpd11493:0:0:"ACP";1:cpd00067:0:0:"H+";1:cpd00834:0:0:"Phosphopantetheine";1:cpd12370:0:0:"apo-ACP"	[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.1.4.14-RXN				
rxn06672	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=BIOTIN-CARBOXYL-RXN				
rxn14361		TRUE		[SW] -sugar- as metabolite too generic					
rxn11025		TRUE		[SW] Uses erroneous compound definition for 1,3-bpg					
rxn11052		TRUE		[SW] Uses erroneous compound definition for 1,3-bpg					
rxn05322			-1:cpd00003:0:0:"NAD";-1:cpd11464:0:0:"Butyryl-ACP";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd11465:0:0:"But-2-enoyl-[acyl-carrier protein]"	[SW] Stoichiometry changed according to MetaCyc and iAF1260	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9657				
rxn05323			-1:cpd00003:0:0:"NAD";-1:cpd11466:0:0:"Myristoyl-ACP";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd11467:0:0:"(2E)-Tetradecenoyl-[acp]"	[SW] Stoichiometry changed according to MetaCyc and iAF1260	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9662				
rxn05356			-1:cpd00006:0:0:"NADP";-1:cpd11474:0:0:"Decanoyl-ACP";1:cpd00005:0:0:"NADPH";1:cpd00067:0:0:"H+";1:cpd11475:0:0:"(2E)-Decenoyl-[acp]"	[SW] Stoichiometry changed according to MetaCyc and iAF1260	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9530				
rxn05355			-1:cpd00006:0:0:"NADP";-1:cpd11468:0:0:"Dodecanoyl-ACP";1:cpd00005:0:0:"NADPH";1:cpd00067:0:0:"H+";1:cpd11469:0:0:"(2E)-Dodecenoyl-[acp]"	[SW] Stoichiometry changed according to MetaCyc and iAF1260	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9534				
rxn05353			-1:cpd00006:0:0:"NADP";-1:cpd11464:0:0:"Butyryl-ACP";1:cpd00005:0:0:"NADPH";1:cpd00067:0:0:"H+";1:cpd11465:0:0:"But-2-enoyl-[acyl-carrier protein]"	[SW] Stoichiometry changed according to MetaCyc and iAF1260	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9515				
rxn05351			-1:cpd00006:0:0:"NADP";-1:cpd11466:0:0:"Myristoyl-ACP";1:cpd00005:0:0:"NADPH";1:cpd00067:0:0:"H+";1:cpd11467:0:0:"(2E)-Tetradecenoyl-[acp]"	[SW] Stoichiometry changed according to MetaCyc and iAF1260	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9538				
rxn04046			-1:cpd00017:0:0:"S-Adenosyl-L-methionine";-1:cpd08368:0:0:"Cobalt-precorrin 2";1:cpd00019:0:0:"S-Adenosyl-homocysteine";1:cpd00067:0:0:"H+";1:cpd08369:0:0:"Cobalt-precorrin 3"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=17997				
rxn04052			-1:cpd08375:0:0:"Cobalt-precorrin 8";1:cpd03421:0:0:"Cobyrinate"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=16209				
rxn04750			-1:cpd00003:0:0:"NAD";-1:cpd09844:0:0:"(3S)-3-Hydroxyadipyl-CoA";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd01507:0:0:"3-Oxoadipyl-CoA"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=34854				
rxn05324			-1:cpd00003:0:0:"NAD";-1:cpd11468:0:0:"Dodecanoyl-ACP";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd11469:0:0:"(2E)-Dodecenoyl-[acp]"	[SW] Stoichiometry changed according to MetaCyc and iAF1260	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9661				
rxn05327			-1:cpd00003:0:0:"NAD";-1:cpd11474:0:0:"Decanoyl-ACP";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd11475:0:0:"(2E)-Decenoyl-[acp]"	[SW] Stoichiometry changed according to MetaCyc and iAF1260	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9660				
rxn05336			-1:cpd00006:0:0:"NADP";-1:cpd11481:0:0:"R-3-hydroxypalmitoyl-acyl-carrierprotein-";1:cpd00005:0:0:"NADPH";1:cpd11485:0:0:"3-oxohexadecanoyl-acp";1:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41904				
rxn05337			-1:cpd00006:0:0:"NADP";-1:cpd11479:0:0:"D-3-Hydroxyhexanoyl-[acp]";1:cpd00005:0:0:"NADPH";1:cpd11486:0:0:"3-Oxohexanoyl-[acp]";1:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41824				
rxn05339			-1:cpd00006:0:0:"NADP";-1:cpd11478:0:0:"(R)-3-Hydroxybutanoyl-[acyl-carrier protein]";1:cpd00005:0:0:"NADPH";1:cpd11488:0:0:"Acetoacetyl-ACP";1:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41824				
rxn05340			-1:cpd00006:0:0:"NADP";-1:cpd11480:0:0:"D-3-Hydroxydodecanoyl-[acp]";1:cpd00005:0:0:"NADPH";1:cpd11489:0:0:"3-oxododecanoyl-acp";1:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41824				
rxn05342			-1:cpd00006:0:0:"NADP";-1:cpd11484:0:0:"HMA";1:cpd00005:0:0:"NADPH";1:cpd11491:0:0:"3-oxotetradecanoyl-acp";1:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41824				
rxn05344			-1:cpd00067:0:0:"H+";-1:cpd11466:0:0:"Myristoyl-ACP";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";1:cpd00011:0:0:"CO2";1:cpd11485:0:0:"3-oxohexadecanoyl-acp";1:cpd11493:0:0:"ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41900				
rxn05345			-1:cpd00067:0:0:"H+";-1:cpd11468:0:0:"Dodecanoyl-ACP";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";1:cpd00011:0:0:"CO2";1:cpd11491:0:0:"3-oxotetradecanoyl-acp";1:cpd11493:0:0:"ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41900				
rxn05346			-1:cpd00067:0:0:"H+";-1:cpd11464:0:0:"Butyryl-ACP";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";1:cpd00011:0:0:"CO2";1:cpd11486:0:0:"3-Oxohexanoyl-[acp]";1:cpd11493:0:0:"ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41900				
rxn05347			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11494:0:0:"Acetyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11488:0:0:"Acetoacetyl-ACP";1:cpd11493:0:0:"ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41900				
rxn05348			-1:cpd00067:0:0:"H+";-1:cpd11474:0:0:"Decanoyl-ACP";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";1:cpd00011:0:0:"CO2";1:cpd11489:0:0:"3-oxododecanoyl-acp";1:cpd11493:0:0:"ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41900				
rxn05343			-1:cpd00067:0:0:"H+";-1:cpd11470:0:0:"Octanoyl-ACP";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";1:cpd00011:0:0:"CO2";1:cpd11487:0:0:"3-oxodecanoyl-acp";1:cpd11493:0:0:"ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41900				
rxn05359			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11495:0:0:"2-methylbutyryl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11496:0:0:"4-methyl-3-oxo-hexanoyl-ACP"	[SW] Stoichiometry changed according to RHEA					
rxn05358			-1:cpd00760:0:0:"2-Methylbutyryl-CoA";-1:cpd11493:0:0:"ACP";1:cpd00010:0:0:"CoA";1:cpd11495:0:0:"2-methylbutyryl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41788				
rxn05383			-1:cpd01882:0:0:"Isovaleryl-CoA";-1:cpd11493:0:0:"ACP";1:cpd00010:0:0:"CoA";1:cpd11520:0:0:"isovaleryl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41788				
rxn05408			-1:cpd00481:0:0:"Isobutyryl-CoA";-1:cpd11493:0:0:"ACP";1:cpd00010:0:0:"CoA";1:cpd11545:0:0:"isobutyryl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41788				
rxn05458			-1:cpd00010:0:0:"CoA";-1:cpd11476:0:0:"hexadecanoyl-acp";1:cpd00134:0:0:"Palmitoyl-CoA";1:cpd11493:0:0:"ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41788				
rxn05459			-1:cpd00010:0:0:"CoA";-1:cpd11573:0:0:"Octodecanoyl-ACP";1:cpd00327:0:0:"strcoa";1:cpd11493:0:0:"ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41788				
rxn05451			-1:cpd00010:0:0:"CoA";-1:cpd00067:0:0:"H+";-1:cpd11515:0:0:"12-methyl-tetra-decanoyl-ACP";1:cpd11439:0:0:"fa4coa";1:cpd11493:0:0:"ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41788				
rxn05452			-1:cpd00010:0:0:"CoA";-1:cpd00067:0:0:"H+";-1:cpd11519:0:0:"14-methyl-hexa-decanoyl-ACP";1:cpd11434:0:0:"fa12coa";1:cpd11493:0:0:"ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41788				
rxn05453			-1:cpd00010:0:0:"CoA";-1:cpd00067:0:0:"H+";-1:cpd11540:0:0:"13-methyl-tetra-decanoyl-ACP";1:cpd11437:0:0:"fa3coa";1:cpd11493:0:0:"ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41788				
rxn05454			-1:cpd00010:0:0:"CoA";-1:cpd00067:0:0:"H+";-1:cpd11544:0:0:"15-methyl-hexa-decanoyl-ACP";1:cpd11432:0:0:"fa11coa";1:cpd11493:0:0:"ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41788				
rxn05455			-1:cpd00010:0:0:"CoA";-1:cpd00067:0:0:"H+";-1:cpd11565:0:0:"12-methyl-tridecanoyl-ACP";1:cpd11435:0:0:"fa1coa";1:cpd11493:0:0:"ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41788				
rxn05456			-1:cpd00010:0:0:"CoA";-1:cpd00067:0:0:"H+";-1:cpd11569:0:0:"14-methyl-pentadecanoyl-ACP";1:cpd11441:0:0:"fa6coa";1:cpd11493:0:0:"ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=41788				
rxn05974		TRUE		[SW] Reaction is unbalanced and cannot be found in any other database than KEGG.					
rxn05771			-8:cpd00067:0:0:"H+";-1:cpd00007:0:0:"O2";-4:cpd11798:0:0:"Ferrocytochrome c2";2:cpd00001:0:0:"H2O";4:cpd11796:0:0:"Ferricytochrome c2";4:cpd00067:1:0:"H+"	[SW] Stoichiometry changed according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CYTOCHROME-C-OXIDASE-RXN				
rxn05772			-1:cpd00004:0:0:"NADH";-2:cpd11795:0:0:"Ferricytochrome b5";1:cpd00003:0:0:"NAD";2:cpd11797:0:0:"Ferrocytochrome b5";1:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CYTOCHROME-B5-REDUCTASE-RXN				
rxn05774			-1:cpd00005:0:0:"NADPH";-2:cpd11796:0:0:"Ferricytochrome c2";1:cpd00006:0:0:"NADP";2:cpd11798:0:0:"Ferrocytochrome c2";1:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=NADPH--CYTOCHROME-C2-REDUCTASE-RXN				
rxn06023			-1:cpd00010:0:0:"CoA";-1:cpd12370:0:0:"apo-ACP";1:cpd00045:0:0:"Adenosine 3-5-bisphosphate";1:cpd11493:0:0:"ACP";1:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=HOLO-ACP-SYNTH-RXN				
rxn06074			-1:cpd00283:0:0:"Geranyldiphosphate";1:cpd00012:0:0:"PPi";1:cpd12822:0:0:"Pinene";1:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-5107				
rxn11963			-1:cpd00001:0:0:"H2O";-1:cpd01042:0:0:"p-Cresol";-4:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00484:0:0:"p-Hydroxybenzaldehyde";4:cpd11620:0:0:"Reducedferredoxin";4:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=1.17.99.1-RXN				
rxn06214			-1:cpd00001:0:0:"H2O";-1:cpd01042:0:0:"p-Cresol";-4:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00484:0:0:"p-Hydroxybenzaldehyde";4:cpd11620:0:0:"Reducedferredoxin";4:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=1.17.99.1-RXN				
rxn06269		TRUE		[SW] Unspecific unbalanced and unconnected reactions.					
rxn06270		TRUE		[SW] Unspecific unbalanced and unconnected reactions.					
rxn06289		TRUE		[SW] Reaction and the participating metabolite -RING- cannot be found in any other database.					
rxn06430		TRUE		[SW] Reaction and the participating metabolite -RING- cannot be found in any other database.					
rxn06541		TRUE		[SW] Reaction and the participating metabolite -RING- cannot be found in any other database.					
rxn06324			-1:cpd00059:0:0:"L-Ascorbate";-1:cpd11795:0:0:"Ferricytochrome b5";1:cpd00766:0:0:"Ascorbate radical";1:cpd11797:0:0:"Ferrocytochrome b5";2:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=18677				
rxn06401			-1:cpd00042:0:0:"GSH";-1:cpd11846:0:0:"RX";1:cpd11844:0:0:"HX";1:cpd12076:0:0:"R-S-Glutathione";1:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=16440				
rxn06428		TRUE		[SW] Unspecific unbalanced and unconnected reactions.					
rxn06455		TRUE		[SW] Reaction not found in any database. Seems to be an reaction later removed from KEGG.					
rxn06470		TRUE		[SW] Unspecific unbalanced and unconnected reactions.					
rxn06516		TRUE		[SW] Unspecific unbalanced and unconnected reactions.					
rxn06548			-1:cpd00001:0:0:"H2O";-1:cpd12681:0:0:"UDP-sugar";1:cpd00091:0:0:"UMP";1:cpd11794:0:0:"beta-L-Aldose 1-phosphate";1:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=UDPSUGARHYDRO-RXN				
rxn06557			-1:cpd11640:0:0:"H2";-2:cpd12157:0:0:"Ferricytochrome c3";2:cpd00067:0:0:"H+";2:cpd12159:0:0:"Ferrocytochrome c3"	[SW] Stoichiometry changed according to MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=CYTOCHROME-C3-HYDROGENASE-RXN				
rxn06599		TRUE		[SW] Unbalanced and unconnected Reaction					
rxn06605		TRUE		[SW] Unbalanced and unconnected Reaction					
rxn35393		TRUE		[SW] Unbalanced and unconnected Reaction					
rxn06606		TRUE		[SW] Unbalanced and unconnected Reaction					
rxn06635		TRUE		[SW] Unbalanced and unconnected Reaction					
rxn06637		TRUE		[SW] Reaction cannot be found in any database.					
rxn06808		TRUE		[SW] Reaction cannot be found in any database.					
rxn06662		TRUE		[SW] Unspecific unbalanced and unconnected reactions.					
rxn06691	>		-2:cpd00067:0:0:"H+";-1:cpd00086:0:0:"Propionyl-CoA";-1:cpd12505:0:0:"Electron-transferring flavoprotein";1:cpd00663:0:0:"Acrylyl-CoA";1:cpd12576:0:0:"Reduced electron-transferring flavoprotein"	[SW] Reaction direction and Stoichiometry adjusted according to RHEA and MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=PROPCOASYN-RXN				
rxn06020	=		-1:cpd00067:0:0:"H+";-1:cpd00001:0:0:"H2O";-1:cpd00425:0:0:"(CH3)2NH";-1:cpd12505:0:0:"Electron-transferring flavoprotein";1:cpd00055:0:0:"Formaldehyde";1:cpd00187:0:0:"Methanamine";1:cpd12576:0:0:"Reduced electron-transferring flavoprotein"	[SW] Reaction direction and Stoichiometry adjusted according to RHEA and MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=1.5.8.1-RXN				
rxn06177	=		-1:cpd00067:0:0:"H+";-1:cpd00001:0:0:"H2O";-1:cpd00441:0:0:"(CH3)3N";-1:cpd12505:0:0:"Electron-transferring flavoprotein";1:cpd00055:0:0:"Formaldehyde";1:cpd00425:0:0:"(CH3)2NH";1:cpd12576:0:0:"Reduced electron-transferring flavoprotein"	[SW] Reaction direction and Stoichiometry adjusted according to RHEA and MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=1.5.8.2-RXN				
rxn06692			-1:cpd11669:0:0:"Q";-1:cpd12576:0:0:"Reduced electron-transferring flavoprotein";1:cpd11665:0:0:"QH2";1:cpd12505:0:0:"Electron-transferring flavoprotein";1:cpd00067:0:0:"H+"	[SW] Reaction direction and Stoichiometry adjusted according to RHEA and MetaCyc.	https://www.rhea-db.org/reaction?id=24052				
rxn06705	>		-1:cpd02703:0:0:"UDP-N-acetyl-beta-D-mannosaminouronate";-1:cpd11649:0:0:"LPS";1:cpd00014:0:0:"UDP";1:cpd12618:0:0:"N-Acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide"	[SW] Reaction direction and Stoichiometry adjusted according to RHEA and MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=UDPMANACATRANS-RXN				
rxn06715	=			[SW] Reaction direction adjusted according to RHEA and MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-9721				
rxn02123	>			[SW] Reaction direction adjusted according to MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=LACTOYL-COA-DEHYDRATASE-RXN				
rxn02182	>			[SW] irrev.					
rxn01818	>			[SW] Reaction direction adjusted according to MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=TRIMETHYLAMINE-OXIDE-ALDOLASE-RXN				
rxn06723			-1:cpd00067:0:0:"H+";-1:cpd02835:0:0:"UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine";-1:cpd11493:0:0:"ACP";1:cpd03584:0:0:"UDP-3-O-(beta-hydroxymyristoyl)-D-glucosamine";1:cpd11484:0:0:"HMA"	[SW] Reaction stoichiometry changed according to MetaCyc and RHEA	https://www.rhea-db.org/reaction?id=17818				
rxn06729			-1:cpd00037:0:0:"UDP-N-acetylglucosamine";-1:cpd11484:0:0:"HMA";1:cpd02886:0:0:"UDP-3-O-(beta-hydroxymyristoyl)-N-acetylglucosamine";1:cpd11493:0:0:"ACP"	[SW] Reaction stoichiometry changed according to MetaCyc and RHEA	https://www.rhea-db.org/reaction?id=13926				
rxn06738	>			[SW] Reaction stoichiometry changed according to MetaCyc and RHEA	https://www.rhea-db.org/reaction?id=13981				
rxn06766			-1:cpd00001:0:0:"H2O";-1:cpd00204:0:0:"CO";-2:cpd12694:0:0:"Ferricytochrome b-561";1:cpd00011:0:0:"CO2";3:cpd00067:0:0:"H+";2:cpd12669:0:0:"Ferrocytochrome b-561"	[SW] Stoichiometry changed, because in seed database carbon monoxide is protonated.					
rxn06768	>		-1:cpd00017:0:0:"S-Adenosyl-L-methionine";-1:cpd12672:0:0:"Dihydroflavodoxin";-1:cpd12673:0:0:"[Formate C-acetyltransferase]-glycine";1:cpd00060:0:0:"L-Methionine";1:cpd03091:0:0:"5'-Deoxyadenosine";1:cpd12674:0:0:"Flavodoxin semiquinone";1:cpd12697:0:0:"[Formate C-acetyltransferase]-glycin-2-yl radical";1:cpd00067:0:0:"H+"	[SW] Reaction direction and stoichiometry adjusted according to MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=TDCEACT-RXN				
rxn06775		TRUE		[SW] Unbalanced and unconnected Reaction					
rxn06875	>		-16:cpd00002:0:0:"ATP";-16:cpd00001:0:0:"H2O";-1:cpd00528:0:0:"N2";-4:cpd12173:0:0:"Reduced flavodoxin";16:cpd00008:0:0:"ADP";16:cpd00009:0:0:"Phosphate";2:cpd00013:0:0:"NH3";4:cpd12207:0:0:"Oxidized flavodoxin";18:cpd00067:0:0:"H+";1:cpd11640:0:0:"H2"	[SW] Reaction stoichiometry changed according to MetaCyc and RHEA	https://www.rhea-db.org/reaction?id=15645				
rxn06880		TRUE		[SW] Unbalanced and unconnected Reaction					
rxn15531		TRUE		[SW] Unbalanced and unconnected Reaction					
rxn10098			-10:cpd00005:0:0:"NADPH";-14:cpd00067:0:0:"H+";-1:cpd11488:0:0:"Acetoacetyl-ACP";-4:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";5:cpd00001:0:0:"H2O";10:cpd00006:0:0:"NADP";4:cpd00011:0:0:"CO2";1:cpd11468:0:0:"Dodecanoyl-ACP";4:cpd11493:0:0:"ACP"	[SW] proton and charge balanced					
rxn10095		TRUE		[SW] not found in any reaction database					
rxn10099	>		-14:cpd00005:0:0:"NADPH";-20:cpd00067:0:0:"H+";-1:cpd11488:0:0:"Acetoacetyl-ACP";-6:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";7:cpd00001:0:0:"H2O";14:cpd00006:0:0:"NADP";6:cpd00011:0:0:"CO2";6:cpd11493:0:0:"ACP";1:cpd15277:0:0:"Palmitoyl-ACP"	[SW] proton and charge balanced					
rxn06940	>		-1:cpd00067:0:0:"H+";-1:cpd06709:0:0:"Benzylsuccinyl-CoA";-1:cpd12505:0:0:"Electron-transferring flavoprotein";1:cpd06710:0:0:"E-Phenylitaconyl-CoA";1:cpd12576:0:0:"Reduced electron-transferring flavoprotein"	[SW] stoichiometry and direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-865				
rxn06959		TRUE		[SW] Unbalanced and generic reaction.					
rxn06979			-2:cpd00001:0:0:"H2O";-2:cpd00002:0:0:"ATP";-2:cpd00053:0:0:"L-Glutamine";-1:cpd03421:0:0:"Cobyrinate";2:cpd00008:0:0:"ADP";2:cpd00009:0:0:"Phosphate";2:cpd00023:0:0:"L-Glutamate";1:cpd03914:0:0:"Cob(II)yrinate diamide";2:cpd00067:0:0:"H+"	[SW] proton and charge balanced					
rxn07058		TRUE		[SW] Unbalanced and unconnected Reaction					
rxn07229		TRUE		[SW] Unbalanced and unconnected Reaction					
rxn07440		TRUE		[SW] Unbalanced and unconnected Reaction					
rxn07586			-1:cpd00001:0:0:"H2O";-1:cpd08371:0:0:"Cobalt-precorrin 5";1:cpd00071:0:0:"Acetaldehyde";1:cpd14960:0:0:"Cobalt-precorrin 5B";1:cpd00067:0:0:"H+"	[SW] Reaction direction adjusted according to RHEA and MetaCyc.	https://www.rhea-db.org/reaction?id=26281				
rxn07587			-1:cpd00017:0:0:"S-Adenosyl-L-methionine";-1:cpd14960:0:0:"Cobalt-precorrin 5B";1:cpd00019:0:0:"S-Adenosyl-homocysteine";1:cpd08372:0:0:"Cobalt-precorrin 6"	[SW] Reaction direction adjusted according to RHEA and MetaCyc.	https://www.rhea-db.org/reaction?id=26286				
rxn07588	>		-1:cpd00017:0:0:"S-Adenosyl-L-methionine";-1:cpd08373:0:0:"Cobalt-precorrin 6B";1:cpd00019:0:0:"S-Adenosyl-homocysteine";1:cpd00011:0:0:"CO2";1:cpd14961:0:0:"Cobalt-precorrin 7"	[SW] Reaction direction adjusted according to RHEA and MetaCyc.	https://www.rhea-db.org/reaction?id=36068				
rxn07589	>		-1:cpd00017:0:0:"S-Adenosyl-L-methionine";-1:cpd14961:0:0:"Cobalt-precorrin 7";1:cpd00067:0:0:"H+";1:cpd00019:0:0:"S-Adenosyl-homocysteine";1:cpd08375:0:0:"Cobalt-precorrin 8"	[SW] Reaction direction adjusted according to RHEA and MetaCyc.	https://www.rhea-db.org/reaction?id=34591				
rxn07997	>		-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd15416:0:0:"cis-dec-3-enoyl-[acyl-carrier protein]";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd15373:0:0:"3-oxo-cis-dodec-5-enoyl-[acyl-carrier protein]"	[SW] Reaction direction adjusted according to RHEA and MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.3.1.41-RXN				
rxn07998	>		-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd15415:0:0:"cis-dodec-5-enoyl-[acyl-carrier protein]";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd15374:0:0:"3-oxo-cis-myristol-7-eoyl-[acyl-carrier protein]"	[SW] Reaction direction adjusted according to RHEA and MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.3.1.41-RXN				
rxn08000	>		-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd15294:0:0:"Tetradecenoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd15375:0:0:"3-oxo-cis-palm-9-eoyl-[acyl-carrier protein]"	[SW] Reaction direction adjusted according to RHEA and MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.3.1.41-RXN				
rxn08001	>		-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd15277:0:0:"Palmitoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd15377:0:0:"3-Oxooctadecanoyl-[acyl-carrier protein]"	[SW] Reaction direction adjusted according to RHEA and MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.3.1.41-RXN				
rxn08002	>		-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd15239:0:0:"Hexadecenoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd15376:0:0:"3-oxo-cis-vacc-11-enoyl-[acyl-carrier protein]"	[SW] Reaction direction adjusted according to RHEA and MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.3.1.41-RXN				
rxn08083	>			[SW] Reaction direction adjusted according to MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=1-ACYLGLYCEROL-3-P-ACYLTRANSFER-RXN				
rxn08085	>		-1:cpd15294:0:0:"Tetradecenoyl-ACP";-1:cpd15330:0:0:"1-tetradec-7-enoyl-sn-glycerol 3-phosphate";1:cpd11493:0:0:"ACP";1:cpd15523:0:0:"1,2-ditetradec-7-enoyl-sn-glycerol 3-phosphate"	[SW] Reaction stoichiometry changed according to MetaCyc and RHEA	https://www.rhea-db.org/reaction?id=42297				
rxn08086	>		-1:cpd15277:0:0:"Palmitoyl-ACP";-1:cpd15327:0:0:"1-hexadecanoyl-sn-glycerol 3-phosphate";1:cpd11493:0:0:"ACP";1:cpd15524:0:0:"1,2-dihexadecanoyl-sn-glycerol 3-phosphate"	[SW] Reaction stoichiometry changed according to MetaCyc and RHEA	https://www.rhea-db.org/reaction?id=42297				
rxn08087	>		-1:cpd15239:0:0:"Hexadecenoyl-ACP";-1:cpd15326:0:0:"1-hexadec-9-enoyl-sn-glycerol 3-phosphate";1:cpd11493:0:0:"ACP";1:cpd15525:0:0:"1,2-dihexadec-9-enoyl-sn-glycerol 3-phosphate"	[SW] Reaction stoichiometry changed according to MetaCyc and RHEA	https://www.rhea-db.org/reaction?id=42297				
rxn08089	>		-1:cpd11825:0:0:"Octadecenoyl-ACP";-1:cpd15328:0:0:"1-octadec-11-enoyl-sn-glycerol 3-phosphate";1:cpd11493:0:0:"ACP";1:cpd15527:0:0:"1,2-dioctadec-11-enoyl-sn-glycerol 3-phosphate"	[SW] Reaction stoichiometry changed according to MetaCyc and RHEA	https://www.rhea-db.org/reaction?id=42297				
rxn08548	>		-1:cpd00067:0:0:"H+";-1:cpd00080:0:0:"Glycerol-3-phosphate";-1:cpd15294:0:0:"Tetradecenoyl-ACP";1:cpd11493:0:0:"ACP";1:cpd15330:0:0:"1-tetradec-7-enoyl-sn-glycerol 3-phosphate"	[SW] proton and charge balanced	https://www.rhea-db.org/reaction?id=42297				
rxn08549	>		-1:cpd00067:0:0:"H+";-1:cpd00080:0:0:"Glycerol-3-phosphate";-1:cpd15277:0:0:"Palmitoyl-ACP";1:cpd11493:0:0:"ACP";1:cpd15327:0:0:"1-hexadecanoyl-sn-glycerol 3-phosphate"	[SW] proton and charge balanced	https://www.rhea-db.org/reaction?id=42297				
rxn08550	>		-1:cpd00067:0:0:"H+";-1:cpd00080:0:0:"Glycerol-3-phosphate";-1:cpd15239:0:0:"Hexadecenoyl-ACP";1:cpd11493:0:0:"ACP";1:cpd15326:0:0:"1-hexadec-9-enoyl-sn-glycerol 3-phosphate"	[SW] proton and charge balanced	https://www.rhea-db.org/reaction?id=42297				
rxn08552	>		-1:cpd00067:0:0:"H+";-1:cpd00080:0:0:"Glycerol-3-phosphate";-1:cpd11825:0:0:"Octadecenoyl-ACP";1:cpd11493:0:0:"ACP";1:cpd15328:0:0:"1-octadec-11-enoyl-sn-glycerol 3-phosphate"	[SW] proton and charge balanced	https://www.rhea-db.org/reaction?id=42297				
rxn08708			-1:cpd00002:0:0:"ATP";-1:cpd15484:0:0:"heptosyl-heptosyl-kdo2-lipidA";1:cpd00008:0:0:"ADP";1:cpd00067:0:0:"H+";1:cpd15549:0:0:"phospho-heptosyl-heptosyl-kdo2-lipidA"	[SW] proton and charge balanced					
rxn08766			-1:cpd00067:0:0:"H+";-1:cpd00022:0:0:"Acetyl-CoA";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";1:cpd00010:0:0:"CoA";1:cpd00011:0:0:"CO2";1:cpd11488:0:0:"Acetoacetyl-ACP"	[SW] Reaction stoichiometry changed according to MetaCyc and RHEA	https://www.rhea-db.org/reaction?id=44448			Beta-ketoacyl-ACP synthase	
rxn08861			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";1:cpd00011:0:0:"CO2";1:cpd11494:0:0:"Acetyl-ACP"	[SW] Reaction stoichiometry changed according to MetaCyc and RHEA	https://www.rhea-db.org/reaction?id=24460				
rxn09442			-2:cpd00005:0:0:"NADPH";-3:cpd00067:0:0:"H+";-1:cpd11470:0:0:"Octanoyl-ACP";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";1:cpd00001:0:0:"H2O";2:cpd00006:0:0:"NADP";1:cpd00011:0:0:"CO2";1:cpd11474:0:0:"Decanoyl-ACP";1:cpd11493:0:0:"ACP"	[SW] proton and charge balanced					
rxn10954			-16:cpd00005:0:0:"NADPH";-23:cpd00067:0:0:"H+";-1:cpd11488:0:0:"Acetoacetyl-ACP";-7:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";8:cpd00001:0:0:"H2O";16:cpd00006:0:0:"NADP";7:cpd00011:0:0:"CO2";7:cpd11493:0:0:"ACP";1:cpd15268:0:0:"Octadecanoyl-ACP"	[SW] proton and charge balanced					
rxn08551			-1:cpd00080:0:0:"Glycerol-3-phosphate";-1:cpd15268:0:0:"Octadecanoyl-ACP";1:cpd11493:0:0:"ACP";1:cpd15329:0:0:"1-octadecanoyl-sn-glycerol 3-phosphate"	[SW] proton and charge balanced					
rxn09456			-1:cpd00001:0:0:"H2O";-1:cpd15268:0:0:"Octadecanoyl-ACP";1:cpd01080:0:0:"ocdca";1:cpd11493:0:0:"ACP";1:cpd00067:0:0:"H+"	[SW] proton and charge balanced					
rxn11557			-1:cpd00007:0:0:"O2";-2:cpd00067:0:0:"H+";-1:cpd00160:0:0:"Cholesterol";-2:cpd11723:0:0:"Reduced adrenodoxin";1:cpd00001:0:0:"H2O";1:cpd03274:0:0:"20alpha-Hydroxycholesterol";2:cpd11724:0:0:"Oxidized adrenodoxin"	[SW] Reaction stoichiometry changed according to MetaCyc and RHEA	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-7875				
rxn06228	>		-3:cpd00007:0:0:"O2";-1:cpd00160:0:0:"Cholesterol";-6:cpd11723:0:0:"Reduced adrenodoxin";-6:cpd00067:0:0:"H+";4:cpd00001:0:0:"H2O";1:cpd01342:0:0:"Pregnenolone";1:cpd01585:0:0:"Isohexanal";6:cpd11724:0:0:"Oxidized adrenodoxin"	[SW] Reaction direction and stoichiometry adjusted according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.14.15.6-RXN				
rxn11562			-1:cpd00007:0:0:"O2";-2:cpd00067:0:0:"H+";-1:cpd00160:0:0:"Cholesterol";-2:cpd11723:0:0:"Reduced adrenodoxin";1:cpd00001:0:0:"H2O";1:cpd03276:0:0:"22beta-Hydroxycholesterol";2:cpd11724:0:0:"Oxidized adrenodoxin"	[SW] Reaction stoichiometry changed according to MetaCyc and RHEA	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-7875				
rxn00019	>			[SW] Reaction direction adjusted according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2-NITROPROPANE-DIOXYGENASE-RXN				
rxn00306	>			[SW] Reaction direction adjusted according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-8988				
rxn02056	<			[SW] Reaction direction adjusted according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=SIROHEME-FERROCHELAT-RXN				
rxn02774	>			[SW] Reaction direction adjusted according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIMETHUROPORDEHYDROG-RXN				
rxn01636	>			[SW] Reaction direction adjusted according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLUTAMATE-N-ACETYLTRANSFERASE-RXN				
rxn00278	>			[SW] Reaction direction adjusted according to MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9771				
rxn00512	>			[SW] Reaction direction adjusted according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLYCOLATEDEHYDRO-RXN				
rxn00633	>			[SW] Reaction direction adjusted according to MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=1.1.99.28-RXN				
rxn15082	>			[SW] Reaction direction adjusted according to MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=1.1.99.28-RXN				
rxn15083	>			[SW] Reaction direction adjusted according to MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=1.1.99.28-RXN				
rxn08616	>			[SW] Glucose:H+ symport mainly for glucose uptake					
rxn05573	>			[SW] Glucose:H+ symport mainly for glucose uptake					
rxn00856	>			[SW] Reaction direction adjusted according to MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=NIL&object=PUTTRANSAM-RXN&redirect=T				
rxn01233	>								
rxn13788	>			[SW] Reaction direction adjusted according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=AMINOBUTDEHYDROG-RXN				
rxn04794	>			[SW] Reaction direction adjusted according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=KETOBUTFORMLY-RXN				
rxn04792	>			[SW] Reaction direction adjusted according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-2962				
rxn04938	>			[SW] Reaction direction adjusted according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-2962				
rxn08460	>			[SW] Reaction direction adjusted according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-2962				
rxn09753			-1:cpd00106:0:0:"Fumarate";-1:cpd00982:0:0:"FADH2";1:cpd00015:0:0:"FAD";1:cpd00036:0:0:"Succinate";1:cpd00067:0:0:"H+"	[SW] Corrected metabolite compartments.					
rxn02988	<			[SW] Reaction direction adjusted according to MetaCyc.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=QUINOLINATE-SYNTHA-RXN				
									
rxn05363			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11499:0:0:"4-methyl-hexanoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11500:0:0:"6-methyl-3-oxo-octanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
rxn05367			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11503:0:0:"6-methyl-octanoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11504:0:0:"8-methyl-3-oxo-decanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
rxn05371			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11507:0:0:"8-methyl-decanoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11508:0:0:"10-methyl-3-oxo-dodecanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
rxn05379			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11515:0:0:"12-methyl-tetra-decanoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11516:0:0:"14-methyl-3-oxo-hexa-decanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
rxn05384			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11520:0:0:"isovaleryl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11521:0:0:"5-methyl-3-oxo-hexanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
rxn05388			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11524:0:0:"5-methyl-hexanoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11525:0:0:"7-methyl-3-oxo-octanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
rxn05392			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11528:0:0:"7-methyl-octanoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11529:0:0:"9-methyl-3-oxo-decanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
rxn05396			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11532:0:0:"9-methyl-decanoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11533:0:0:"11-methyl-3-oxo-dodecanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
rxn05400			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11536:0:0:"11-methyl-dodecanoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11537:0:0:"13-methyl-3-oxo-tetra-decanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
rxn05404			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11540:0:0:"13-methyl-tetra-decanoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11541:0:0:"15-methyl-3-oxo-hexa-decanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
rxn05409			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11545:0:0:"isobutyryl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11546:0:0:"4-methyl-3-oxo-pentanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
rxn05413			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11549:0:0:"4-methyl-pentanoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11550:0:0:"6-methyl-3-oxo-heptanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
rxn05417			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11553:0:0:"6-methyl-heptanoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11554:0:0:"8-methyl-3-oxo-nonanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
rxn05421			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11557:0:0:"8-methyl-nonanoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11558:0:0:"10-methyl-3-oxo-undecanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
rxn05425			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11561:0:0:"10-methyl-undecanoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11562:0:0:"12-methyl-3-oxo-tridecanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
rxn05429			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11565:0:0:"12-methyl-tridecanoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11566:0:0:"14-methyl-3-oxo-pentadecanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
rxn05375			-1:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11511:0:0:"10-methyl-dodecanoyl-ACP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11512:0:0:"12-methyl-3-oxo-tetra-decanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
rxn05460			-1:cpd00067:0:0:"H+";-1:cpd11476:0:0:"hexadecanoyl-acp";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd11570:0:0:"3-Oxooctodecanoyl-ACP"	[SW] Stoichiometry changed according to RHEA	https://www.rhea-db.org/reaction?id=22836				
									
									
rxn08783		TRUE		[SW] Literature on existence of this reaction is inconclusive.					
rxn08792		TRUE		[SW] Literature on existence of this reaction is inconclusive.					
rxn08793		TRUE		[SW] Literature on existence of this reaction is inconclusive.					
rxn10900		TRUE		[SW] Literature on existence of this reaction is inconclusive.					
rxn13717		TRUE		[SW] Literature on existence of this reaction is inconclusive.					
rxn13718		TRUE		[SW] Literature on existence of this reaction is inconclusive.					
rxn13719		TRUE		[SW] Literature on existence of this reaction is inconclusive.					
rxn13720		TRUE		[SW] Literature on existence of this reaction is inconclusive.					
rxn36711		TRUE		[SW] Literature on existence of this reaction is inconclusive.					
rxn37677		TRUE		[SW] Literature on existence of this reaction is inconclusive.					
									
rxn08448	>		-1:cpd00067:1:0:"H+";-1:cpd00002:0:0:"ATP";-1:cpd00010:0:0:"CoA";-1:cpd01107:1:0:"Decanoate";1:cpd00012:0:0:"PPi";1:cpd00018:0:0:"AMP";1:cpd03128:0:0:"Decanoyl-CoA";2:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-7248				
rxn08449	>		-1:cpd00067:1:0:"H+";-1:cpd00002:0:0:"ATP";-1:cpd00010:0:0:"CoA";-1:cpd01741:1:0:"ddca";1:cpd00012:0:0:"PPi";1:cpd00018:0:0:"AMP";2:cpd00067:0:0:"H+";1:cpd01260:0:0:"Lauroyl-CoA"	[SW] Stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-7248				
rxn08450	>		-1:cpd00067:1:0:"H+";-1:cpd00002:0:0:"ATP";-1:cpd00010:0:0:"CoA";-1:cpd03847:1:0:"Myristic acid";1:cpd00012:0:0:"PPi";1:cpd00018:0:0:"AMP";2:cpd00067:0:0:"H+";1:cpd01695:0:0:"Myristoyl-CoA"	[SW] Stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-7248				
rxn08451	>		-1:cpd00067:1:0:"H+";-1:cpd00002:0:0:"ATP";-1:cpd00010:0:0:"CoA";-1:cpd15298:1:0:"tetradecenoate";1:cpd00012:0:0:"PPi";1:cpd00018:0:0:"AMP";1:cpd15295:0:0:"Tetradecenoyl-CoA";1:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-7248				
rxn08452	>		-1:cpd00067:1:0:"H+";-1:cpd00002:0:0:"ATP";-1:cpd00010:0:0:"CoA";-1:cpd00214:1:0:"Palmitate";1:cpd00012:0:0:"PPi";1:cpd00018:0:0:"AMP";2:cpd00067:0:0:"H+";1:cpd00134:0:0:"Palmitoyl-CoA"	[SW] Stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-7248				
rxn08453	>		-1:cpd00067:1:0:"H+";-1:cpd00002:0:0:"ATP";-1:cpd00010:0:0:"CoA";-1:cpd15237:1:0:"hexadecenoate";1:cpd00012:0:0:"PPi";1:cpd00018:0:0:"AMP";1:cpd15238:0:0:"Hexadecenoyl-CoA";1:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-7248				
rxn08454	>		-1:cpd00067:1:0:"H+";-1:cpd00002:0:0:"ATP";-1:cpd00010:0:0:"CoA";-1:cpd01080:1:0:"ocdca";1:cpd00012:0:0:"PPi";1:cpd00018:0:0:"AMP";2:cpd00067:0:0:"H+";1:cpd00327:0:0:"strcoa"	[SW] Stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-7248				
rxn08455	>		-1:cpd00067:1:0:"H+";-1:cpd00002:0:0:"ATP";-1:cpd00010:0:0:"CoA";-1:cpd15269:1:0:"octadecenoate";1:cpd00012:0:0:"PPi";1:cpd00018:0:0:"AMP";1:cpd15274:0:0:"Octadecenoyl-CoA";1:cpd00067:0:0:"H+"	[SW] Stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-7248				
rxn08456	>		-1:cpd00067:1:0:"H+";-1:cpd00002:0:0:"ATP";-1:cpd00010:0:0:"CoA";-1:cpd01113:1:0:"Hexanoate";1:cpd00012:0:0:"PPi";1:cpd00018:0:0:"AMP";2:cpd00067:0:0:"H+";1:cpd03124:0:0:"Hexanoyl-CoA"	[SW] Stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-7248				
rxn08457	>		-1:cpd00067:1:0:"H+";-1:cpd00002:0:0:"ATP";-1:cpd00010:0:0:"CoA";-1:cpd03846:1:0:"octanoate";1:cpd00012:0:0:"PPi";1:cpd00018:0:0:"AMP";2:cpd00067:0:0:"H+";1:cpd01335:0:0:"Octanoyl-CoA"	[SW] Stoichiometry changed according to MetaCyc. 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-7248				
									
rxn16094		TRUE		[SW] Reaction not found in any other database and caused futile cycles.					
rxn16104		TRUE		[SW] Reaction not found in any other database and caused futile cycles.					
									
rxn12957	=			[SW] direction changed according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=4.2.1.17#SUBSTRATE				
rxn12958	=			[SW] direction changed according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=4.2.1.17#SUBSTRATE				
rxn12959	=			[SW] direction changed according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=4.2.1.17#SUBSTRATE				
rxn12960	=			[SW] direction changed according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=4.2.1.17#SUBSTRATE				
rxn12961	=			[SW] direction changed according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=4.2.1.17#SUBSTRATE				
rxn12962	=		-1:cpd00001:0:0:"H2O";-1:cpd16852:0:0:"trans-delta2-octaenoyl-CoA";1:cpd16779:0:0:"3-hydroxyoctanoyl-CoA"	[SW] direction changed according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=4.2.1.17#SUBSTRATE				
rxn12963	=		-1:cpd00001:0:0:"H2O";-1:cpd16851:0:0:"trans-delta2-hexaenoyl-CoA";1:cpd16777:0:0:"3-hydroxyhexanoyl-CoA"	[SW] direction changed according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=4.2.1.17#SUBSTRATE				
rxn12964	=		-1:cpd00001:0:0:"H2O";-1:cpd16848:0:0:"trans-delta2-butaenoyl-CoA";1:cpd03043:0:0:"3-Hydroxybutanoyl-CoA"	[SW] direction changed according to BRENDA	http://www.brenda-enzymes.org/enzyme.php?ecno=4.2.1.17#SUBSTRATE				
									
rxn08734	>			[SW] unsure, but highly exergonic reaction	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-5256				
rxn08735	>			[SW] unsure, but highly exergonic reaction	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-5256				
rxn08736	>			[SW] unsure, but highly exergonic reaction	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-5256				
rxn10117	>			[SW] unsure, but highly exergonic reaction	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-5256				
rxn10118	>			[SW] unsure, but highly exergonic reaction	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-5256				
rxn10119	>			[SW] unsure, but highly exergonic reaction	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-5256				
rxn10507	>		-2:cpd00067:0:0:"H+";-2:cpd11620:0:0:"Reducedferredoxin";1:cpd11640:0:0:"H2";2:cpd11621:0:0:"Oxidizedferredoxin"	[SW] hydrogenase can perform H2 evolution. Stoich. Adjusted according to MetaCyc.	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=HYDROG-RXN				
									
rxn13063	>			[SW] Fatty-acyl CoA-oxidase in direction of hydrogen peroxide formation. According to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11026				
rxn13064	>			[SW] Fatty-acyl CoA-oxidase in direction of hydrogen peroxide formation. According to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11026				
rxn13065	>		-1:cpd00007:0:0:"O2";-1:cpd01260:0:0:"Lauroyl-CoA";1:cpd00025:0:0:"H2O2";1:cpd16850:0:0:"trans-delta2-dodecaenoyl-CoA"	[SW] Fatty-acyl CoA-oxidase in direction of hydrogen peroxide formation. According to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11026				
rxn13066	>		-1:cpd00007:0:0:"O2";-1:cpd03128:0:0:"Decanoyl-CoA";1:cpd00025:0:0:"H2O2";1:cpd16849:0:0:"trans-delta2-decaenoyl-CoA"	[SW] Fatty-acyl CoA-oxidase in direction of hydrogen peroxide formation. According to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11026				
rxn13067	>		-1:cpd00007:0:0:"O2";-1:cpd01335:0:0:"Octanoyl-CoA";1:cpd00025:0:0:"H2O2";1:cpd16852:0:0:"trans-delta2-octaenoyl-CoA"	[SW] Fatty-acyl CoA-oxidase in direction of hydrogen peroxide formation. According to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11026				
rxn13068	>		-1:cpd00007:0:0:"O2";-1:cpd03124:0:0:"Hexanoyl-CoA";1:cpd00025:0:0:"H2O2";1:cpd16851:0:0:"trans-delta2-hexaenoyl-CoA"	[SW] Fatty-acyl CoA-oxidase in direction of hydrogen peroxide formation. According to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11026				
rxn13069	>		-1:cpd00007:0:0:"O2";-1:cpd00120:0:0:"Butyryl-CoA";1:cpd00025:0:0:"H2O2";1:cpd16848:0:0:"trans-delta2-butaenoyl-CoA"	[SW] Fatty-acyl CoA-oxidase in direction of hydrogen peroxide formation. According to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11026				
									
rxn05554	>			[SW] direction changed according to MetaCyc	https://ecocyc.org/gene?orgid=ECOLI&id=UHPT-MONOMER#tab=RXNS				
rxn05563	>			[SW] direction changed according to MetaCyc	https://ecocyc.org/gene?orgid=ECOLI&id=UHPT-MONOMER#tab=RXNS				
rxn08431	>			[SW] direction changed according to MetaCyc	https://ecocyc.org/gene?orgid=ECOLI&id=UHPT-MONOMER#tab=RXNS				
rxn08569	>			[SW] direction changed according to MetaCyc	https://ecocyc.org/gene?orgid=ECOLI&id=UHPT-MONOMER#tab=RXNS				
rxn08879	>			[SW] direction changed according to MetaCyc	https://ecocyc.org/gene?orgid=ECOLI&id=UHPT-MONOMER#tab=RXNS				
rxn10187	>			[SW] direction changed according to MetaCyc	https://ecocyc.org/gene?orgid=ECOLI&id=UHPT-MONOMER#tab=RXNS				
rxn05562	>			[SW] direction changed according to MetaCyc	https://ecocyc.org/gene?orgid=ECOLI&id=UHPT-MONOMER#tab=RXNS				
rxn10188	>			[SW] direction changed according to MetaCyc	https://ecocyc.org/gene?orgid=ECOLI&id=UHPT-MONOMER#tab=RXNS				
rxn08642	>			[SW] direction changed according to MetaCyc	https://ecocyc.org/gene?orgid=ECOLI&id=UHPT-MONOMER#tab=RXNS				
rxn10165	>			[SW] direction changed according to MetaCyc	https://ecocyc.org/gene?orgid=ECOLI&id=UHPT-MONOMER#tab=RXNS				
									
rxn12965	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN66-485				
rxn12966	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN66-485				
rxn12967	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN66-485				
rxn12968	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN66-485				
rxn12969	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN66-485				
rxn12970	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN66-485				
									
									
rxn00650	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12844	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12845	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12846	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12847	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn00350	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn06528	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn06744	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn07466	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn08007	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn08073	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn08074	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn08076	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn08077	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn08078	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn08123	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn08124	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn08125	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn08133	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn09359	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12633	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12634	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12635	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12636	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12637	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12638	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12639	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12640	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12641	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12642	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12643	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12644	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12645	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn12646	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn14121	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn14135	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn16621	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
rxn18043	>			[SW] Peptidases are irreversible.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.4.11.1-RXN				
									
rxn12893		TRUE		[SW] the term "Lactate" is too unspecific as is does not denote stereochemistry. Thus Lactate might not be linked with reactions that utilize either L-lactate or D-lactate.					
rxn11137		TRUE		[SW] the term "Lactate" is too unspecific as is does not denote stereochemistry. Thus Lactate might not be linked with reactions that utilize either L-lactate or D-lactate.					
rxn12893		TRUE		[SW] the term "Lactate" is too unspecific as is does not denote stereochemistry. Thus Lactate might not be linked with reactions that utilize either L-lactate or D-lactate.					
rxn12983		TRUE		[SW] the term "Lactate" is too unspecific as is does not denote stereochemistry. Thus Lactate might not be linked with reactions that utilize either L-lactate or D-lactate.					
rxn13119		TRUE		[SW] the term "Lactate" is too unspecific as is does not denote stereochemistry. Thus Lactate might not be linked with reactions that utilize either L-lactate or D-lactate.					
rxn11116		TRUE		[SW] the term "Lactate" is too unspecific as is does not denote stereochemistry. Thus Lactate might not be linked with reactions that utilize either L-lactate or D-lactate.					
rxn30133		TRUE		[SW] the term "Lactate" is too unspecific as is does not denote stereochemistry. Thus Lactate might not be linked with reactions that utilize either L-lactate or D-lactate.					
rxn32268		TRUE		[SW] the term "Lactate" is too unspecific as is does not denote stereochemistry. Thus Lactate might not be linked with reactions that utilize either L-lactate or D-lactate.					
rxn32805		TRUE		[SW] the term "Lactate" is too unspecific as is does not denote stereochemistry. Thus Lactate might not be linked with reactions that utilize either L-lactate or D-lactate.					
									
rxn09125	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
rxn09127	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
rxn09129	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
rxn09132	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
rxn09134	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
rxn09136	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
rxn09139	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
rxn09141	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
rxn09143	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
rxn09146	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
rxn09148	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
rxn09150	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
rxn09153	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
rxn09155	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
rxn09157	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
rxn09160	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
rxn09162	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
rxn09164	>			[SW] Reversible according to Metacyc & BRENDA.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1602 # http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.34#NATURAL%20SUBSTRATES				
									
rxn03117		TRUE		[SW] Non relevant for current gapseq version					
rxn06719		TRUE		[SW] Non relevant for current gapseq version					
									
rxn05769		TRUE		[SW] generic reaction.					
rxn05770		TRUE		[SW] generic reaction.					
rxn05781		TRUE		[SW] generic reaction.					
rxn05782		TRUE		[SW] generic reaction.					
rxn05838		TRUE		[SW] generic reaction.					
rxn05839		TRUE		[SW] generic reaction.					
rxn05897		TRUE		[SW] generic reaction.					
rxn05997		TRUE		[SW] generic reaction.					
rxn06032		TRUE		[SW] generic reaction.					
rxn06085		TRUE		[SW] generic reaction.					
rxn06116		TRUE		[SW] generic reaction.					
rxn06211		TRUE		[SW] generic reaction.					
rxn06305		TRUE		[SW] generic reaction.					
rxn11641		TRUE		[SW] generic reaction.					
rxn07235		TRUE		[SW] generic reaction.					
rxn07457		TRUE		[SW] generic reaction.					
rxn07056		TRUE		[SW] generic reaction.					
rxn05778		TRUE		[SW] generic reaction.					
rxn05779		TRUE		[SW] generic reaction.					
									
rxn05871		TRUE		[SW] generic reaction.					
rxn05872		TRUE		[SW] generic reaction.					
rxn05873		TRUE		[SW] generic reaction.					
rxn05881		TRUE		[SW] generic reaction.					
rxn05882		TRUE		[SW] generic reaction.					
rxn05883		TRUE		[SW] generic reaction.					
rxn06056		TRUE		[SW] generic reaction.					
rxn06148		TRUE		[SW] generic reaction.					
rxn06155		TRUE		[SW] generic reaction.					
rxn07204		TRUE		[SW] generic reaction.					
rxn11883		TRUE		[SW] generic reaction.					
rxn14204		TRUE		[SW] generic reaction.					
rxn15053		TRUE		[SW] generic reaction.					
rxn15169		TRUE		[SW] generic reaction.					
rxn15216		TRUE		[SW] generic reaction.					
rxn15303		TRUE		[SW] generic reaction.					
rxn15315		TRUE		[SW] generic reaction.					
rxn15365		TRUE		[SW] generic reaction.					
rxn15470		TRUE		[SW] generic reaction.					
rxn15906		TRUE		[SW] generic reaction.					
									
rxn06336		TRUE		[SW] Non-existing reaction					
rxn05809		TRUE		[SW] Non-existing reaction					
rxn05810		TRUE		[SW] Non-existing reaction					
rxn05811		TRUE		[SW] Non-existing reaction					
rxn05932		TRUE		[SW] Non-existing reaction					
rxn05993		TRUE		[SW] Non-existing reaction					
rxn06587		TRUE		[SW] Non-existing reaction					
rxn06639		TRUE		[SW] Non-existing reaction					
									
rxn00008		TRUE		[SW] Unbalanced reaction. Not found in MetaCyc					
rxn06418		TRUE		[SW] Highly unbalanced. Not found in other Databases. Correct version of this reaction is likely: rxn02570					
rxn12825		TRUE		[SW] Highly unbalanced. Not found in other Databases. Correct version of this reaction is likely: rxn10048					
rxn12950		TRUE		[SW] Incorrect reaction according to EC number.					
rxn14429		TRUE		[SW] Unbalanced reaction. Not found in MetaCyc					
rxn32333		TRUE		[SW] nn. Del.					
									
rxn10772		TRUE		[SW] Removing all reactions with ammonium hydroxide, as they are all unbalanced and not found in MetaCyc					
rxn13808		TRUE		[SW] Removing all reactions with ammonium hydroxide, as they are all unbalanced and not found in MetaCyc					
rxn14028		TRUE		[SW] Removing all reactions with ammonium hydroxide, as they are all unbalanced and not found in MetaCyc					
rxn14395		TRUE		[SW] Removing all reactions with ammonium hydroxide, as they are all unbalanced and not found in MetaCyc					
rxn20287		TRUE		[SW] Removing all reactions with ammonium hydroxide, as they are all unbalanced and not found in MetaCyc					
rxn25215		TRUE		[SW] Removing all reactions with ammonium hydroxide, as they are all unbalanced and not found in MetaCyc					
									
rxn12359		TRUE		[SW] generic reaction.					
rxn12344		TRUE		[SW] generic reaction.					
rxn12348		TRUE		[SW] generic reaction.					
rxn12349		TRUE		[SW] generic reaction.					
rxn12351		TRUE		[SW] generic reaction.					
rxn12357		TRUE		[SW] generic reaction.					
rxn10383		TRUE		[SW] generic reaction.					
rxn11053		TRUE		[SW] generic reaction.					
rxn11163		TRUE		[SW] generic reaction.					
rxn05829		TRUE		[SW] generic reaction.					
rxn05834		TRUE		[SW] generic reaction.					
rxn12332		TRUE		[SW] generic reaction.					
rxn12331		TRUE		[SW] generic reaction.					
rxn12304		TRUE		[SW] generic reaction.					
rxn12305		TRUE		[SW] generic reaction.					
rxn06406		TRUE		[SW] generic reaction.					
rxn06407		TRUE		[SW] generic reaction.					
rxn06408		TRUE		[SW] generic reaction.					
rxn12496		TRUE		[SW] generic reaction.					
rxn12214		TRUE		[SW] generic reaction.					
rxn06650		TRUE		[SW] generic reaction.					
rxn30642		TRUE		[SW] generic reaction.					
rxn06109		TRUE		[SW] generic reaction.					
rxn12212		TRUE		[SW] generic reaction.					
rxn12213		TRUE		[SW] generic reaction.					
rxn06195		TRUE		[SW] generic reaction.					
rxn06196		TRUE		[SW] generic reaction.					
									
rxn08014	>			[SW] Fatty acid ligase. Elongation not reversible as such.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-13266				
rxn05465	>		-1:cpd00070:0:0:"Malonyl-CoA";-1:cpd11493:0:0:"ACP";1:cpd00010:0:0:"CoA";1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-"	[SW] Fatty acid ligase. Elongation not reversible as such. (2.3.1.39). Stoichiometry changed accordig to RHEA.	https://www.rhea-db.org/reaction?id=41792				
rxn09436	>		-2:cpd00005:0:0:"NADPH";-3:cpd00067:0:0:"H+";-1:cpd11468:0:0:"Dodecanoyl-ACP";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";1:cpd00001:0:0:"H2O";2:cpd00006:0:0:"NADP";1:cpd00011:0:0:"CO2";1:cpd11466:0:0:"Myristoyl-ACP";1:cpd11493:0:0:"ACP"	[SW] Fatty acid elongation not reversible as such. Proton and charge balanced.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3-OXOACYL-ACP-SYNTH-RXN				
rxn10097	>		-12:cpd00005:0:0:"NADPH";-17:cpd00067:0:0:"H+";-1:cpd11488:0:0:"Acetoacetyl-ACP";-5:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";6:cpd00001:0:0:"H2O";12:cpd00006:0:0:"NADP";5:cpd00011:0:0:"CO2";1:cpd11466:0:0:"Myristoyl-ACP";5:cpd11493:0:0:"ACP"	[SW] Fatty acid elongation not reversible as such.					
rxn09434	>			[SW] Fatty acid elongation not reversible as such.					
rxn10954	>			[SW] Fatty acid elongation not reversible as such.					
rxn08392	>			[SW] Fatty acid elongation not reversible as such.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9663				
									
rxn12215		TRUE		[SW] Unsure. Not in MetaCyc or RHEA.					
rxn11535		TRUE		[SW] Unsure. Caused unusal C1-cycles including SAM and methanol.					
rxn11537		TRUE		[SW] Unsure. Caused unusal C1-cycles including SAM and methanol.					
									
rxn05758		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn05767		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn05780		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn06055		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn06245		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn06783		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn06902		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn06903		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn06911		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn06920		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn06925		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn06927		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn11652		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn11658		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn11686		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn11947		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn11949		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn14045		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn14047		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn14086		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn14352		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn14364		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn15610		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn16153		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn16164		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn16640		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn19838		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn20770		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn20771		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn22255		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn22824		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn23077		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn23078		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn25467		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26151		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26153		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26154		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26155		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26156		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26157		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26179		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26195		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26266		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26267		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26268		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26290		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26299		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26308		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26392		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26393		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26411		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26442		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn26443		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn27207		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn27319		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn28219		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn28535		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn28790		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn30973		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn30986		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn30987		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn31281		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn31471		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn32467		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
rxn32771		TRUE		[SW] Electrons should not be part of reactions as they are no metabolites and do not float around freely.					
									
rxn13254		TRUE		[SW] yeast specific					
rxn13255		TRUE		[SW] yeast specific					
rxn13257		TRUE		[SW] yeast specific					
rxn13258		TRUE		[SW] yeast specific					
rxn13287		TRUE		[SW] yeast specific					
rxn13288		TRUE		[SW] yeast specific					
rxn13335		TRUE		[SW] yeast specific					
rxn13336		TRUE		[SW] yeast specific					
rxn13416		TRUE		[SW] yeast specific					
rxn13417		TRUE		[SW] yeast specific					
									
rxn05269		TRUE		[SW] yeast specific(?) odd reaction anyway					
rxn10410		TRUE		[SW] yeast specific(?) odd reaction anyway					
									
rxn13699	>			[SW] Fatty acid oxidation is not reversible.					
rxn10104	>			[SW] Fatty acid oxidation is not reversible.					
rxn10105	>			[SW] Fatty acid oxidation is not reversible.					
rxn10106	>			[SW] Fatty acid oxidation is not reversible.					
rxn10643	>			[SW] Fatty acid oxidation is not reversible.					
rxn10663	>			[SW] Fatty acid oxidation is not reversible.					
rxn13697	>			[SW] Fatty acid oxidation is not reversible.					
rxn13698	>			[SW] Fatty acid oxidation is not reversible.					
rxn30478	>			[SW] Fatty acid oxidation is not reversible.					
rxn10074	>			[SW] Fatty acid oxidation is not reversible.					
rxn12270	>			[SW] Fatty acid oxidation is not reversible.					
rxn12275	>			[SW] Fatty acid oxidation is not reversible.					
rxn12281	>			[SW] Fatty acid oxidation is not reversible.					
rxn12286	>			[SW] Fatty acid oxidation is not reversible.					
rxn13472	>			[SW] Fatty acid oxidation is not reversible.					
									
rxn06440	>			[SW] Aminocyl-tRNA ligases are irreversible, as they are highly exergonic reactions.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ISOLEUCINE--TRNA-LIGASE-RXN				
rxn11122	>			[SW] Aminocyl-tRNA ligases are irreversible, as they are highly exergonic reactions.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ISOLEUCINE--TRNA-LIGASE-RXN				
rxn06438	>			[SW] Aminocyl-tRNA ligases are irreversible, as they are highly exergonic reactions.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ISOLEUCINE--TRNA-LIGASE-RXN				
									
rxn05760	<		-2:cpd00023:0:0:"L-Glutamate";-2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00024:0:0:"2-Oxoglutarate";1:cpd00053:0:0:"L-Glutamine";2:cpd00067:0:0:"H+";2:cpd11620:0:0:"Reducedferredoxin"						
rxn05902	<		-3:cpd00001:0:0:"H2O";-1:cpd00239:0:0:"H2S";-6:cpd11621:0:0:"Oxidizedferredoxin";6:cpd00067:0:0:"H+";1:cpd00081:0:0:"Sulfite";6:cpd11620:0:0:"Reducedferredoxin"	[JZ][SW] reaction not proton balanced. Changing stoichiometries	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=SULFITE-REDUCTASE-FERREDOXIN-RXN				
rxn05937	>		-1:cpd00006:0:0:"NADP";-1:cpd00067:0:0:"H+";-2:cpd11620:0:0:"Reducedferredoxin";1:cpd00005:0:0:"NADPH";2:cpd11621:0:0:"Oxidizedferredoxin"	[SW] Reaction was incomplete. Here newly balanced full reaction.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-17897				
rxn06990	>		-1:cpd00003:0:0:"NAD";-1:cpd00067:0:0:"H+";-2:cpd11620:0:0:"Reducedferredoxin";1:cpd00004:0:0:"NADH";2:cpd11621:0:0:"Oxidizedferredoxin"	[SW] Ferredoxin Stoichiometries corrected. Reverse direction possible, but only in the presense of sodium ion potential.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=FERREDOXIN--NAD%2b-REDUCTASE-RXN # Hess, V.; Schuchmann, K.; Mueller, V.; J. Biol. Chem. 288, 31496-31502 (2013)				
rxn07849	>		-1:cpd00001:0:0:"H2O";-1:cpd00735:0:0:"Formylmethanofuran";-2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00011:0:0:"CO2";1:cpd00643:0:0:"Methanofuran";2:cpd11620:0:0:"Reducedferredoxin";1:cpd00067:0:0:"H+"	[JZ][SW] Reaction was incomplete. Here new balances full reaction with correct oxidized/reduced state for ferredoxin	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=FORMYLMETHANOFURAN-DEHYDROGENASE-RXN				
rxn05938	=		-1:cpd00011:0:0:"CO2";-1:cpd00022:0:0:"Acetyl-CoA";-1:cpd00067:0:0:"H+";-2:cpd11620:0:0:"Reducedferredoxin";1:cpd00010:0:0:"CoA";1:cpd00020:0:0:"Pyruvate";2:cpd11621:0:0:"Oxidizedferredoxin"	[SW] Should be reversible.	https://www.brenda-enzymes.org/enzyme.php?ecno=3.5.4.27#NATURAL%20SUBSTRATES				
rxn05939	=		-1:cpd00011:0:0:"CO2";-1:cpd00067:0:0:"H+";-1:cpd00078:0:0:"Succinyl-CoA";-2:cpd11620:0:0:"Reducedferredoxin";1:cpd00010:0:0:"CoA";1:cpd00024:0:0:"2-Oxoglutarate";2:cpd11621:0:0:"Oxidizedferredoxin"	[SW] reported for both directions.	http://www.brenda-enzymes.org/enzyme.php?ecno=1.2.7.3#NATURAL%20SUBSTRATES				
rxn05940	>		-1:cpd00010:0:0:"CoA";-1:cpd00094:0:0:"2-Oxobutyrate";-2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00011:0:0:"CO2";1:cpd00067:0:0:"H+";1:cpd00086:0:0:"Propionyl-CoA";2:cpd11620:0:0:"Reducedferredoxin"						
rxn05942	>		-2:cpd00067:0:0:"H+";-1:cpd00125:0:0:"5-10-Methylenetetrahydrofolate";-2:cpd11620:0:0:"Reducedferredoxin";1:cpd00345:0:0:"5-Methyltetrahydrofolate";2:cpd11621:0:0:"Oxidizedferredoxin"	[SW] direction changed according to MetaCyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-5061				
rxn06133	>		-1:cpd00007:0:0:"O2";-2:cpd00067:0:0:"H+";-1:cpd00325:0:0:"Progesterone";-2:cpd11620:0:0:"Reducedferredoxin";1:cpd00001:0:0:"H2O";1:cpd03272:0:0:"11beta-Hydroxyprogesterone";2:cpd11621:0:0:"Oxidizedferredoxin"						
rxn06262	>		-1:cpd00007:0:0:"O2";-2:cpd00067:0:0:"H+";-1:cpd03268:0:0:"Cortodoxone";-2:cpd11620:0:0:"Reducedferredoxin";1:cpd00001:0:0:"H2O";1:cpd00546:0:0:"Cortisol";2:cpd11621:0:0:"Oxidizedferredoxin"						
rxn06329	>		-2:cpd00067:0:0:"H+";-1:cpd00752:0:0:"6-Hydroxynicotinate";-2:cpd11620:0:0:"Reducedferredoxin";1:cpd02598:0:0:"1,4,5,6-Tetrahydro-6-oxonicotinate";2:cpd11621:0:0:"Oxidizedferredoxin"						
rxn06424	<		-1:cpd00001:0:0:"H2O";-1:cpd01099:0:0:"Calcidiol";-2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00007:0:0:"O2";2:cpd00067:0:0:"H+";1:cpd03226:0:0:"Vitamin D3";2:cpd11620:0:0:"Reducedferredoxin"						
rxn06451	<		-1:cpd03509:0:0:"(3Z)-Phytochromobilin";-2:cpd11621:0:0:"Oxidizedferredoxin";2:cpd00067:0:0:"H+";1:cpd00389:0:0:"Biliverdin";2:cpd11620:0:0:"Reducedferredoxin"						
rxn06507	>		-1:cpd00007:0:0:"O2";-2:cpd00067:0:0:"H+";-1:cpd02047:0:0:"DOC";-2:cpd11620:0:0:"Reducedferredoxin";1:cpd00001:0:0:"H2O";1:cpd01450:0:0:"Corticosterone";2:cpd11621:0:0:"Oxidizedferredoxin"						
rxn06926	>		-8:cpd00001:0:0:"H2O";-8:cpd00002:0:0:"ATP";-1:cpd01090:0:0:"Ethyne";-4:cpd11620:0:0:"Reducedferredoxin";4:cpd00067:0:0:"H+";8:cpd00008:0:0:"ADP";8:cpd00009:0:0:"Phosphate";1:cpd03956:0:0:"Ethylene";4:cpd11621:0:0:"Oxidizedferredoxin";1:cpd11640:0:0:"H2"						
rxn07189	=		-1:cpd00001:0:0:"H2O";-1:cpd00204:0:0:"CO";-2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00011:0:0:"CO2";3:cpd00067:0:0:"H+";2:cpd11620:0:0:"Reducedferredoxin"						
rxn07191	>		-1:cpd00001:0:0:"H2O";-1:cpd00102:0:0:"Glyceraldehyde3-phosphate";-2:cpd11621:0:0:"Oxidizedferredoxin";3:cpd00067:0:0:"H+";1:cpd00169:0:0:"3-Phosphoglycerate";2:cpd11620:0:0:"Reducedferredoxin"		https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.2.7.5-RXN				
rxn13775	>		-2:cpd00047:0:0:"Formate";-2:cpd11621:0:0:"Oxidizedferredoxin";-1:cpd00003:0:0:"NAD";2:cpd00011:0:0:"CO2";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";2:cpd11620:0:0:"Reducedferredoxin"		http://www.rhea-db.org/reaction?id=46952				
									
									
rxn05651	=		-1:cpd00048:1:0:"Sulfate";-2:cpd00067:1:0:"H+";1:cpd00048:0:0:"Sulfate";2:cpd00067:0:0:"H+"	[SW] Rule: sulfate:proton symport with ratio 2:1		transport			
rxn11268			-1:cpd00012:1:0:"PPi";-3:cpd00067:1:0:"H+";1:cpd00012:0:0:"PPi";3:cpd00067:0:0:"H+"	[SW] Rule: diphosphate:proton symport with ratio 3:1					
rxn11395			-1:cpd00012:1:0:"PPi";-3:cpd00067:1:0:"H+";1:cpd00012:0:0:"PPi";3:cpd00067:0:0:"H+"	[SW] Rule: diphosphate:proton symport with ratio 3:1					
rxn09270	>			[SW] Proton antiport only in the direction of proton flow into the cell. Ok		transport			
rxn08655	>			[SW] New direction according to Metacyc	https://biocyc.org/META/new-image?object=RXN-969				
rxn08900	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXNI-3				
rxn08792	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN				
rxn08783	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN				
rxn00399	>			[SW] New direction according to Metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=NITRIC-OXIDE-SYNTHASE-RXN				
rxn09304	>			[SW] Proton antiport only in the direction of proton flow into the cell. Ok 		transport			
rxn05305	>			[SW] Proton antiport only in the direction of proton flow into the cell. Ok		transport			
rxn09295	>			[SW] Hydride transfer only from NADH to NADP+.	DOI: 10.1016/j.bbabio.2012.04.006				
rxn27378	>			[SW] Hydride transfer only from NADH to NADP+.	DOI: 10.1016/j.bbabio.2012.04.006				
rxn08154	>			[SW] Proton antiport only in the direction of proton flow into the cell. Ok		transport			
rxn08730		TRUE		Proton diffusion across membrane should be omitted.					
rxn27372		TRUE		Proton diffusion across membrane should be omitted.					
rxn26298		TRUE		Proton diffusion across membrane should be omitted.					
rxn05312	=		-1:cpd00009:1:0:"Phosphate";-2:cpd00067:1:0:"H+";1:cpd00009:0:0:"Phosphate";2:cpd00067:0:0:"H+"	[SW] Rule: phosphate:proton symport with ratio 2:1		transport			
									
									
rxn08750		TRUE		[SW] Indole can pass without proton motion		transport			
									
rxn09731	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn05687	>			[SW] ptrc:H+ symport only described for import	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=TRANS-RXN-69	transport			
									
rxn10560	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn12526	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn12527	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn12567	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn12586	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn12597	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn12607	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn12621	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn12622	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn12625	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn12631	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn13392	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn13398	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29255		TRUE		[SW] generic reaction.		transport			
rxn29256		TRUE		[SW] Transport with wrong metabolite identifier.		transport			
rxn29262	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29263	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29492		TRUE		[SW] generic reaction.		transport			
rxn29736	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29791	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29827	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29828	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29829	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29830	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29831	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29832	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29833	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29834	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29835	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29836	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29837	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29838	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29839	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29840	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29841	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29842	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29843	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29844	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29845	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29846	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn29847	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn30230	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn34203	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn34228	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn34247	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn34390	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn34512	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn34534	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
									
									
									
									
									
rxn12379		TRUE		Transport reactions with Protons in periplasmic space are currently omitted.					
rxn12370		TRUE		Transport reactions with Protons in periplasmic space are currently omitted.					
rxn12378		TRUE		Transport reactions with Protons in periplasmic space are currently omitted.					
rxn12421		TRUE		Transport reactions with Protons in periplasmic space are currently omitted.					
rxn12437		TRUE		Transport reactions with Protons in periplasmic space are currently omitted.					
rxn12439		TRUE		Transport reactions with Protons in periplasmic space are currently omitted.					
rxn12449		TRUE		Transport reactions with Protons in periplasmic space are currently omitted.					
rxn12450		TRUE		Transport reactions with Protons in periplasmic space are currently omitted.					
rxn12455		TRUE		Transport reactions with Protons in periplasmic space are currently omitted.					
rxn12458		TRUE		Transport reactions with Protons in periplasmic space are currently omitted.					
									
rxn09653	>			[SW] Only for uptake of urea into root cells at low urea concentrations.	PMID: 12615950				
									
rxn07924		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn07925		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn07926		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn07927		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn07928		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn07931		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn07972		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn07973		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn07974		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn07975		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08004		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08005		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08006		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08009		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08012		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08030		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08036		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08037		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08039		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08042		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08047		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08049		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08051		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08059		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08063		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08065		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08069		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08082		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08096		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08099		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08104		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08115		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08117		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08134		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08135		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08142		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08155		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08159		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08170		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08175		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08182		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08184		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08186		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08197		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08211		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08214		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08217		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08234		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08236		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08241		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08265		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08267		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08279		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08283		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08284		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08290		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08293		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08302		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08303		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08305		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08314		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08315		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08317		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08320		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08322		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08324		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08342		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08344		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08351		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08363		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08373		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08374		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08375		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08377		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08424		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08426		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08432		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08475		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08525		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08537		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08539		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08540		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08544		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08545		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08554		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08560		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08562		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08564		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08566		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08570		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08572		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08574		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08577		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08579		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08581		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08585		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08587		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08589		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08593		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08595		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08600		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08610		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08614		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
									
rxn08621		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08623		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08625		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08633		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08639		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08640		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08643		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08645		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08653		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08664		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08672		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08674		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08677		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08680		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08682		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08702		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08721		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08723		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08726		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08732		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08737		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08743		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08747		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08749		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08754		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08755		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08759		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08780		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08786		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08795		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08856		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08859		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08864		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08868		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08870		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08873		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08874		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08876		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08878		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08880		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08883		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08886		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08908		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08911		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08920		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08925		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08945		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08950		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08960		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08985		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08991		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08999		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09005		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09030		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09036		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09048		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09050		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09061		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09080		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09118		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09121		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09166		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09172		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09183		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09185		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09190		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09193		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09204		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09216		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09218		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09223		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09228		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09229		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09243		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09248		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09257		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09260		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09266		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09271		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09275		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09278		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09284		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09286		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09287		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09299		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09300		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09303		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09307		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09309		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09318		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09323		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09330		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09334		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09335		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09337		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09339		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09342		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09347		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09349		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09352		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09353		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09361		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09366		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09372		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09378		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09380		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09382		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09385		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09387		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09390		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09642		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09648		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09741		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09742		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09765		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09766		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09768		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09789		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09791		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09793		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09794		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09796		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09805		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09807		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09823		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn12784		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn12789		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn12793		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn12795		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn12809		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn12812		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn12817		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn12818		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn13345		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn13406		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn13407		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn05616		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08947		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn05206		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn08028		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn09771		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn05292		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/	diffusion			
rxn05238		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn27375		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn13365		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn31201		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn23651		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn12420		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn34296		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn08662		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn32020		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09839		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn05222		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09327		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn34118		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn12803		TRUE		large polar molecules or small charged molecules cannot cross the membrane at significant rates.	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
									
rxn09898	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09899	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09900	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09901	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09902	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09904	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09905	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09906	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09909	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09910	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09911	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09912	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09913	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09914	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09916	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09917	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09918	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09919	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09921	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09922	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09923	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09924	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09927	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09928	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09929	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09930	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09932	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09933	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09934	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09935	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09936	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09937	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
rxn09938	>			ATP-Depending amino acid ligases are generally irreversible	E.g.: https://biocyc.org/gene?orgid=META&id=DALADALALIGA-MONOMER				
									
rxn00137	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn00360	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn00363	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn00550	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn00708	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn00766	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn00831	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn00881	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn00882	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn00883	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn00913	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn00980	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01104	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01139	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01145	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01218	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01317	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01367	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01398	<			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01445	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01507	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01521	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01539	<			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01549	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01596	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01670	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01704	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01808	<			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01883	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01961	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn02046	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn02160	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn02166	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn02388	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn02400	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn02404	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn02417	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn02418	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn02434	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn02435	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn02455	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn02458	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn02461	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn02499	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn02790	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn02909	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn03002	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn03035	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn03150	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn03919	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn04037	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn04038	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn04376	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn04377	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn04683	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn04684	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn05039	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn05106	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn07413	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn07414	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn07415	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn07489	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn08035	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn08038	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn08571	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn09991	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn12188	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn13949	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn14260	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn15030	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn15095	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn15250	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn15256	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn15257	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn15361	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn15494	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn15853	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn16373	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn16507	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn16613	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn17401	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn19467	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn19639	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn19811	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn19850	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn20172	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn20527	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn20572	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn20820	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn21242	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn21246	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn21248	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn21253	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn21254	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn21256	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn21261	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn21622	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn22073	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn22131	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn22340	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn22472	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn23467	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn24404	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn24520	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn25123	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.				alkaline phosphatase	
rxn25963	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn26129	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn26130	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn26560	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn26561	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn26562	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn26563	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn26564	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn27010	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn27205	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn33589	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn33927	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn36936	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn36937	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn36938	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn37439	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn13448	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn13447	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01006	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01909	<			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn00106	>		-1:cpd00001:0:0:"H2O";-1:cpd00421:0:0:"Triphosphate";1:cpd00009:0:0:"Phosphate";1:cpd00012:0:0:"PPi";1:cpd00067:0:0:"H+"	[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn09016	>		-1:cpd00001:0:0:"H2O";-1:cpd00038:0:0:"GTP";1:cpd00311:0:0:"Guanosine";1:cpd00421:0:0:"Triphosphate";1:cpd00067:0:0:"H+"	[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn15103	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn15102	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
rxn01352	>			[SW] Phosphates are usually irreversible, as they would build a high energy phosphate bond without energy source.					
									
rxn08617		TRUE		[SW] Glucose diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn05245		TRUE		[SW] Valine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09375		TRUE		[SW] Valine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn29139		TRUE		[SW] Valine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn33518		TRUE		[SW] Valine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn33520		TRUE		[SW] Valine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn05218		TRUE		[SW] Glycine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn13111		TRUE		[SW] Glycine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn31188		TRUE		[SW] Glycine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn11336		TRUE		[SW] Phenylacetic acid diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn12774		TRUE		[SW] Phenylacetic acid diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn10826		TRUE		[SW] Carbonic acid diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn13310		TRUE		[SW] Carbonic acid diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn29060		TRUE		[SW] Carbonic acid diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn29238		TRUE		[SW] Carbonic acid diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn31553		TRUE		[SW] Carbonic acid diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn13195		TRUE		[SW] 2-oxobutyrate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn29351		TRUE		[SW] 2-oxobutyrate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn08534		TRUE		[SW] Fructoselysine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn29171		TRUE		[SW] Fructoselysine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09331		TRUE		[SW] Myristic acid  diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09654		TRUE		[SW] Myristic acid  diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09852		TRUE		[SW] Myristic acid  diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09034		TRUE		[SW] Octadecanoate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09669		TRUE		[SW] Octadecanoate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn34366		TRUE		[SW] Octadecanoate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn07930		TRUE		[SW] 2,3-Diaminopropionate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn08704		TRUE		[SW] Palmitate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09676		TRUE		[SW] Palmitate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09848		TRUE		[SW] Palmitate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn31182		TRUE		[SW] Palmitate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09196		TRUE		[SW] psicoselysine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn29172		TRUE		[SW] psicoselysine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn11320		TRUE		[SW] Acetyllactic acid diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn13114		TRUE		[SW] Acetyllactic acid diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn32770		TRUE		[SW] Acetyllactic acid diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn12404		TRUE		[SW] D-Aspartate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn30250		TRUE		[SW] D-Aspartate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn12452		TRUE		[SW] Quinate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn31859		TRUE		[SW] Quinate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn31862		TRUE		[SW] Quinate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn31865		TRUE		[SW] Quinate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09792		TRUE		[SW] 4-Hydroxybenzoate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn12787		TRUE		[SW] 4-Hydroxybenzoate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn10936		TRUE		[SW] Acetamide diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn05580		TRUE		[SW] Glycogen diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn13298		TRUE		[SW] Glycogen diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn30289		TRUE		[SW] Glycogen diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn30290		TRUE		[SW] Glycogen diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn12246		TRUE		[SW] Protocatechuate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn12672		TRUE		[SW] Protocatechuate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn05310		TRUE		[SW] Niacin diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn08969		TRUE		[SW] Niacin diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn08970		TRUE		[SW] Niacin diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn05568		TRUE		[SW] D-glucosamine 6-phosphate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn08591		TRUE		[SW] D-glucosamine 6-phosphate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn13642		TRUE		[SW] D-glucosamine 6-phosphate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn12401		TRUE		[SW] Salicylic acid diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn05499		TRUE		[SW] D-arabinose diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn32874		TRUE		[SW] D-arabinose diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn32883		TRUE		[SW] D-arabinose diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn05212		TRUE		[SW] Copper diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn08273		TRUE		[SW] Copper diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn08274		TRUE		[SW] Copper diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn38516		TRUE		[SW] Copper diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn08995		TRUE		[SW] Nucleotide diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn08997		TRUE		[SW] Nucleotide diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn10181		TRUE		[SW] Nucleotide diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn05220		TRUE		[SW] L-asparagine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn08162		TRUE		[SW] L-asparagine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn32042		TRUE		[SW] L-asparagine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn32043		TRUE		[SW] L-asparagine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn05586		TRUE		[SW] Hg2+ diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn08717		TRUE		[SW] Hg2+ diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn10867		TRUE		[SW] Nicotinamide diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn32452		TRUE		[SW] Nicotinamide diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn32456		TRUE		[SW] Nicotinamide diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09784		TRUE		[SW] SAM diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09826		TRUE		[SW] SAM diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn29883		TRUE		[SW] SAM diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn32578		TRUE		[SW] SAM diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn32583		TRUE		[SW] SAM diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn34146		TRUE		[SW] SAM diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn34470		TRUE		[SW] SAM diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09788		TRUE		[SW] Acetylcarnitine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09867		TRUE		[SW] Acetylcarnitine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn08265		TRUE		[SW] Carnitine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09691		TRUE		[SW] Carnitine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09773		TRUE		[SW] Carnitine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09858		TRUE		[SW] Carnitine diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09790		TRUE		[SW] 5-Aminolevulinate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn05483		TRUE		[SW] L-lyxitol diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn38747		TRUE		[SW] L-lyxitol diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn05653		TRUE		[SW] l-Sorbose diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn28581		TRUE		[SW] l-Sorbose diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn38740		TRUE		[SW] l-Sorbose diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn12786		TRUE		[SW] 3-oxodipate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn12396		TRUE		[SW] caffeate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn12785		TRUE		[SW] caffeate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn31780		TRUE		[SW] caffeate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn12436		TRUE		[SW] Benzoate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09651		TRUE		[SW] Xylitol diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn32606		TRUE		[SW] Xylitol diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn09661		TRUE		[SW] Gulitol diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
rxn12797		TRUE		[SW] Gallate diffusion across membrane unlikely	https://www.ncbi.nlm.nih.gov/books/NBK9847/				
									
rxn09713		TRUE		[SW] Unsure. However, only reported in few cases and only mitochondrial.	http://www.tcdb.org/search/result.php?tc=2.A.29.2.7				
rxn05645	>			[SW] Proton symport uses membrane-proton potential: Force works only for import under phsysiological conditions.					
									
									
rxn05225	<			[SW] Proton symport uses membrane-proton potential: Force works only for import under phsysiological conditions.					
rxn05708	>			[SW] Proton symport uses membrane-proton potential: Force works only for import under phsysiological conditions.		transport			
rxn08427	>			[SW] Proton symport uses membrane-proton potential: Force works only for import under phsysiological conditions.					
rxn12553	>			[SW] Proton symport uses membrane-proton potential: Force works only for import under phsysiological conditions.		transport			
rxn12606	>			[SW] Proton symport uses membrane-proton potential: Force works only for import under phsysiological conditions.		transport			
									
rxn10977	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn08141	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn08907	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn05652	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn10860	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.					
rxn10818	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn05615	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn09660	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn05626	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn08474	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn08779	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn08722	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn13245	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.					
rxn09308	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn05553	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn11158	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported. + [JZ] updated reaction name		transport		ammonia transporter	
rxn13415	<			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.					
									
									
rxn05523	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.					
rxn12529	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn13339	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn13301	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn13229	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn13321	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn13314	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn13411	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn05526	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.		transport			
rxn05511	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.					
rxn10426	>			H+-coupled transport w/o chemical transformation of transported molecule should work only in the direction where protons are imported.					
									
									
									
									
rxn01206	>			[SW] irrev on kegg map rn00460					
rxn01377	>			[SW] irrev on kegg map rn00460					
									
rxn10155			-1:cpd00041:1:0:"L-Aspartate";-1:cpd00067:1:0:"H+";1:cpd00041:0:0:"L-Aspartate";1:cpd00067:0:0:"H+"	[SW] Rule: Organic acid H+ symport: ratio 1:1 to prevent import-export futile cycles.					
									
									
									
									
									
									
rxn10151			-1:cpd00041:1:0:"L-Aspartate";-1:cpd00067:1:0:"H+";1:cpd00041:0:0:"L-Aspartate";1:cpd00067:0:0:"H+"	[SW] Rule: Organic acid H+ symport: ratio 1:1 to prevent import-export futile cycles.					
rxn08169			-1:cpd00041:1:0:"L-Aspartate";-1:cpd00067:1:0:"H+";1:cpd00041:0:0:"L-Aspartate";1:cpd00067:0:0:"H+"	[SW] Rule: Organic acid H+ symport: ratio 1:1 to prevent import-export futile cycles.					
									
									
									
rxn09049			-1:cpd00067:1:0:"H+";-1:cpd00247:1:0:"Orotate";1:cpd00067:0:0:"H+";1:cpd00247:0:0:"Orotate"	[SW] Rule: Organic acid H+ symport: ratio 1:1 to prevent import-export futile cycles.					
									
rxn05654			-1:cpd00036:1:0:"Succinate";-2:cpd00067:1:0:"H+";1:cpd00036:0:0:"Succinate";2:cpd00067:0:0:"H+"	[SW] New Succ Rule: Succ H+ symport: ratio 1:2 to prevent import-export futile cycles.	10.1128/ecosalplus.esp-0021-2015				
rxn10157			-1:cpd00036:1:0:"Succinate";-2:cpd00067:1:0:"H+";1:cpd00036:0:0:"Succinate";2:cpd00067:0:0:"H+"	[SW] New Succ Rule: Succ H+ symport: ratio 1:2 to prevent import-export futile cycles.	10.1128/ecosalplus.esp-0021-2015				
rxn05561			-2:cpd00067:1:0:"H+";-1:cpd00106:1:0:"Fumarate";2:cpd00067:0:0:"H+";1:cpd00106:0:0:"Fumarate"	[SW] New Succ Rule: Succ H+ symport: ratio 1:2 to prevent import-export futile cycles.	10.1128/ecosalplus.esp-0021-2015				
rxn08543			-2:cpd00067:1:0:"H+";-1:cpd00106:1:0:"Fumarate";2:cpd00067:0:0:"H+";1:cpd00106:0:0:"Fumarate"	[SW] New Succ Rule: Succ H+ symport: ratio 1:2 to prevent import-export futile cycles.	10.1128/ecosalplus.esp-0021-2015				
rxn05603			-2:cpd00067:1:0:"H+";-1:cpd00386:1:0:"D-Malate";2:cpd00067:0:0:"H+";1:cpd00386:0:0:"D-Malate"						
rxn05605			-2:cpd00067:1:0:"H+";-1:cpd00130:1:0:"L-Malate";2:cpd00067:0:0:"H+";1:cpd00130:0:0:"L-Malate"						
rxn08866			-2:cpd00067:1:0:"H+";-1:cpd00130:1:0:"L-Malate";2:cpd00067:0:0:"H+";1:cpd00130:0:0:"L-Malate"						
rxn05211			-3:cpd00067:1:0:"H+";-1:cpd00137:1:0:"Citrate";3:cpd00067:0:0:"H+";1:cpd00137:0:0:"Citrate"						
rxn05493			-1:cpd00024:1:0:"2-Oxoglutarate";-2:cpd00067:1:0:"H+";1:cpd00024:0:0:"2-Oxoglutarate";2:cpd00067:0:0:"H+"						
rxn09733			-1:cpd00032:0:0:"Oxaloacetate";-2:cpd00067:0:0:"H+";1:cpd00032:1:0:"Oxaloacetate";2:cpd00067:1:0:"H+"						
rxn05590			-3:cpd00067:1:0:"H+";-1:cpd00260:1:0:"Isocitrate";3:cpd00067:0:0:"H+";1:cpd00260:0:0:"Isocitrate"						
rxn05630			-1:cpd00061:1:0:"Phosphoenolpyruvate";-3:cpd00067:1:0:"H+";1:cpd00061:0:0:"Phosphoenolpyruvate";3:cpd00067:0:0:"H+"						
									
									
rxn05208			-2:cpd00067:1:0:"H+";-1:cpd00130:1:0:"L-Malate";-1:cpd00159:0:0:"L-Lactate";-1:cpd00971:0:0:"Na+";2:cpd00067:0:0:"H+";1:cpd00130:0:0:"L-Malate";1:cpd00159:1:0:"L-Lactate";1:cpd00971:1:0:"Na+"						
rxn05604			-2:cpd00067:1:0:"H+";-1:cpd00130:1:0:"L-Malate";-1:cpd00159:0:0:"L-Lactate";-1:cpd00971:0:0:"Na+";2:cpd00067:0:0:"H+";1:cpd00130:0:0:"L-Malate";1:cpd00159:1:0:"L-Lactate";1:cpd00971:1:0:"Na+"						
rxn09862			-1:cpd00130:0:0:"L-Malate";-1:cpd00137:1:0:"Citrate";-1:cpd00067:1:0:"H+";1:cpd00130:1:0:"L-Malate";1:cpd00137:0:0:"Citrate";1:cpd00067:0:0:"H+"						
rxn09779			-1:cpd00130:1:0:"L-Malate";-1:cpd00137:0:0:"Citrate";-1:cpd00067:0:0:"H+";1:cpd00130:0:0:"L-Malate";1:cpd00137:1:0:"Citrate";1:cpd00067:1:0:"H+"						
rxn08216			-1:cpd00036:0:0:"Succinate";-1:cpd00137:1:0:"Citrate";-1:cpd00067:1:0:"H+";1:cpd00036:1:0:"Succinate";1:cpd00137:0:0:"Citrate";1:cpd00067:0:0:"H+"						
									
rxn05207			-1:cpd00130:1:0:"L-Malate";-2:cpd00971:1:0:"Na+";1:cpd00130:0:0:"L-Malate";2:cpd00971:0:0:"Na+"						
rxn11077			-1:cpd00063:1:0:"Ca2+";-1:cpd00067:1:0:"H+";-1:cpd00137:1:0:"Citrate";1:cpd00063:0:0:"Ca2+";1:cpd00067:0:0:"H+";1:cpd00137:0:0:"Citrate"						
rxn12432			-1:cpd00308:1:0:"Malonate";-2:cpd00971:1:0:"Na+";1:cpd00308:0:0:"Malonate";2:cpd00971:0:0:"Na+"						
rxn11078			-1:cpd00067:1:0:"H+";-1:cpd00137:1:0:"Citrate";-1:cpd00254:1:0:"Mg";1:cpd00067:0:0:"H+";1:cpd00137:0:0:"Citrate";1:cpd00254:0:0:"Mg"						
									
rxn05514			-1:cpd00063:0:0:"Ca2+";-2:cpd00067:1:0:"H+";1:cpd00063:1:0:"Ca2+";2:cpd00067:0:0:"H+"						
rxn08240			-2:cpd00067:1:0:"H+";-1:cpd00149:0:0:"Co2+";2:cpd00067:0:0:"H+";1:cpd00149:1:0:"Co2+"						
rxn08990			-2:cpd00067:1:0:"H+";-1:cpd00244:0:0:"Ni2+";2:cpd00067:0:0:"H+";1:cpd00244:1:0:"Ni2+"						
rxn05618			-1:cpd00030:1:0:"Mn2+";-2:cpd00067:0:0:"H+";1:cpd00030:0:0:"Mn2+";2:cpd00067:1:0:"H+"					manganese transport in via proton antiport	
rxn09389			-1:cpd00034:0:0:"Zn2+";-2:cpd00067:1:0:"H+";1:cpd00034:1:0:"Zn2+";2:cpd00067:0:0:"H+"						
rxn08946			-1:cpd00030:0:0:"Mn2+";-2:cpd00067:1:0:"H+";1:cpd00030:1:0:"Mn2+";2:cpd00067:0:0:"H+"						
									
									
rxn08982			-1:cpd00067:1:0:"H+";-1:cpd00971:0:0:"Na+";1:cpd00067:0:0:"H+";1:cpd00971:1:0:"Na+"	[SW] Rule: Na+/H+ antiport has the ratio 1:1					
rxn08983			-1:cpd00067:1:0:"H+";-1:cpd00971:0:0:"Na+";1:cpd00067:0:0:"H+";1:cpd00971:1:0:"Na+"	[SW] Rule: Na+/H+ antiport has the ratio 1:1					
rxn13722			-2:cpd00067:0:0:"H+";-1:cpd00254:1:0:"Mg";2:cpd00067:1:0:"H+";1:cpd00254:0:0:"Mg"	[SW] Rule: Mg2+/H+ antiport has ratio 1:2					
rxn08689			-1:cpd00239:0:0:"H2S";-1:cpd00067:0:0:"H+";1:cpd00239:1:0:"H2S";1:cpd00067:1:0:"H+"						
									
rxn90001	>		-2:cpd00004:0:0:"NADH";-2:cpd11621:0:0:"Oxidizedferredoxin";-1:cpd00650:0:0:"Crotonyl-CoA";2:cpd00003:0:0:"NAD";2:cpd11620:0:0:"Reducedferredoxin";1:cpd00120:0:0:"Butyryl-CoA"	[SW] new reaction. Essential for butyrate production in Clostridia.	Li, Hinderberger, Seedorf, Zhang, Buckel, Thauer (2008) Journal of Bacteriology		But-CoA dehydrogenase ETF	Butyryl-CoA dehydrogenase (Etf complex)	
rxn90002	>		-1:cpd90001:0:0:"2-Fucosyllactose";-1:cpd00001:0:0:"H2O";1:cpd00208:0:0:"LACT";1:cpd00751:0:0:"L-Fucose"	[SW] new reaction for the degradation of the most common human oligosaccharide 2-fucosyllactose	10.1073/pnas.0809584105		2-FL hydrolase	1,2-alpha-L-fucosidase (HMO)	
rxn90003	>		-1:cpd00001:0:0:"H2O";-1:cpd00002:0:0:"ATP";-1:cpd90001:1:0:"2-Fucosyllactose";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate";1:cpd90001:0:0:"2-Fucosyllactose";1:cpd00067:0:0:"H+"	[SW] new reaction for import of 2-FL via ABC-transport.	10.1073/pnas.0809584105		2-FL ABC transport	2-Fucosyllactose ABC transporter	
rxn90004	>		-1:cpd00001:1:0:"H2O";-1:cpd03807:1:0:"Lacto-N-tetraose";1:cpd01354:1:0:"beta-Lactose";1:cpd03808:1:0:"Lacto-N-biose"	[SW] new reaction. Same as rxn15525 but extracellular	https://doi.org/10.1038/srep38560		LNT LNB-hydrolase (extc)	lacto-N-tetraose lacto-N-biosylhydrolase (extracellular)	
rxn90005	>		-1:cpd00001:0:0:"H2O";-1:cpd00002:0:0:"ATP";-1:cpd01354:1:0:"beta-Lactose";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate";1:cpd00067:0:0:"H+";1:cpd01354:0:0:"beta-Lactose"	[SW] new reaction. Same as rxn05598 but for beta-lactose instead of alpha-lactose (LACT)			betaLACT-ABCtrans	ATP phosphohydrolase (lbeta-lactose importing)	
rxn90006	>		-1:cpd00067:1:0:"H+";-1:cpd01354:0:0:"beta-Lactose";1:cpd00067:0:0:"H+";1:cpd01354:1:0:"beta-Lactose"	[SW] new reaction. Same as rxn08779 but for beta-lactose instead of alpha-lactose (LACT)			bLACT.Hp.antiport	Beta-lactose / H+ antiporter	
rxn90007	=		-1:cpd00067:1:0:"H+";-1:cpd01354:1:0:"beta-Lactose";1:cpd00067:0:0:"H+";1:cpd01354:0:0:"beta-Lactose"	[SW] new reaction. Same as rxn08781 but for beta-lactose instead of alpha-lactose (LACT)			bLACT.Hp.symport	Beta-lactose / H+ symporter	
rxn90008	>		-1:cpd00061:0:0:"Phosphoenolpyruvate";-1:cpd01354:1:0:"beta-Lactose";1:cpd00020:0:0:"Pyruvate";1:cpd03194:0:0:"Lactose-6-phosphate"	[SW] new reaction. Same as rxn10865 but for beta-lactose instead of alpha-lactose (LACT)			betaLACpts	Lactose transport via PEP:Pyr PTS	
rxn90009	>		-1:cpd00001:0:0:"H2O";-1:cpd00002:0:0:"ATP";-1:cpd03808:1:0:"Lacto-N-biose";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate";1:cpd00067:0:0:"H+";1:cpd03808:0:0:"Lacto-N-biose"	[SW] new reaction for import of LNB via ABC-transport.			LNB-ABCtrans	Lacto-N-biose ABC transporter	
rxn90010	>		-1:cpd18011:0:0:"L-Fucono-1,5-lactone";-1:cpd00001:0:0:"H2O";1:cpd00067:0:0:"H+";1:cpd01185:0:0:"L-Fuconate"	[SW] New reaction for second step of L-fucose degradtion without phosphorylated intermediates.	10.1186/s12866-016-0867-4		L-fuc hydrolase	L-fuconolactone hydrolase	
rxn90011	>		-1:cpd00003:0:0:"NAD";-1:cpd02387:0:0:"2-Dehydro-3-deoxy-L-fuconate";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd90002:0:0:"L-2,4-diketo-3-deoxyfuconate"	[SW] New reaction for fourth step of L-fucose degradtion without phosphorylated intermediates.	10.1186/s12866-016-0867-4		2-keto-3-deoxy-L-fuconate dehydrogenase	2-keto-3-deoxy-L-fuconate dehydrogenase	
rxn90012	>		-1:cpd00001:0:0:"H2O";-1:cpd90002:0:0:"L-2,4-diketo-3-deoxyfuconate";1:cpd00020:0:0:"Pyruvate";1:cpd00067:0:0:"H+";1:cpd00159:0:0:"L-Lactate"	[SW] New reaction for fifth and last step of L-fucose degradtion without phosphorylated intermediates.	10.1186/s12866-016-0867-4		2,4-diketo-3-deoxy-l-fuconate hydrolase	2,4-diketo-3-deoxy-l-fuconate hydrolase	
									
rxn90013	>		-1:cpd00047:0:0:"Formate";-1:cpd00067:0:0:"H+";-1:cpd00002:0:0:"ATP";1:cpd00115:0:0:"dATP";1:cpd00001:0:0:"H2O";1:cpd00011:0:0:"CO2"	[SW] New Reaction. anaerobic ribonucleoside-triphosphate reductase.	https://metacyc.org/META/substring-search?type=NIL&object=1.1.98.6&quickSearch=Quick+Search		ATP-rd	Anaerobic Adenosine desoxribonucleotide-triphosphate reductase	
rxn90014	>		-1:cpd00047:0:0:"Formate";-1:cpd00067:0:0:"H+";-1:cpd00052:0:0:"CTP";1:cpd00356:0:0:"dCTP";1:cpd00001:0:0:"H2O";1:cpd00011:0:0:"CO2"	[SW] New Reaction. anaerobic ribonucleoside-triphosphate reductase.	https://metacyc.org/META/substring-search?type=NIL&object=1.1.98.6&quickSearch=Quick+Search		CTP-rd	Anaerobic Cytosine desoxribonucleotide-triphosphate reductase	
rxn90015	>		-1:cpd00047:0:0:"Formate";-1:cpd00067:0:0:"H+";-1:cpd00038:0:0:"GTP";1:cpd00241:0:0:"dGTP";1:cpd00001:0:0:"H2O";1:cpd00011:0:0:"CO2"	[SW] New Reaction. anaerobic ribonucleoside-triphosphate reductase.	https://metacyc.org/META/substring-search?type=NIL&object=1.1.98.6&quickSearch=Quick+Search		GTP-rd	Anaerobic Guanine desoxribonucleotide-triphosphate reductase	
rxn90016	>		-1:cpd00047:0:0:"Formate";-1:cpd00067:0:0:"H+";-1:cpd00062:0:0:"UTP";1:cpd00358:0:0:"dUTP";1:cpd00001:0:0:"H2O";1:cpd00011:0:0:"CO2"	[SW] New Reaction. anaerobic ribonucleoside-triphosphate reductase.	https://metacyc.org/META/substring-search?type=NIL&object=1.1.98.6&quickSearch=Quick+Search		UTP-rd	Anaerobic Uridine desoxribonucleotide-triphosphate reductase	
									
rxn90017	>		-1:cpd00017:0:0:"S-Adenosyl-L-methionine";-1:cpd00069:0:0:"L-Tyrosine";-1:cpd00005:0:0:"NADPH";1:cpd00060:0:0:"L-Methionine";1:cpd00067:0:0:"H+";1:cpd01042:0:0:"p-Cresol";1:cpd03091:0:0:"5'-Deoxyadenosine";1:cpd14545:0:0:"Iminoglycine";1:cpd00006:0:0:"NADP"	[SW] New Reaction. Important for Thiman biosynthesis.	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-11319&detail-level=3		2-iminoacetate synthase	2-iminoacetate synthase	
rxn90018	>		-2:cpd11620:0:0:"Reducedferredoxin";-2:cpd00006:0:0:"NADP";-1:cpd00004:0:0:"NADH";-1:cpd00067:0:0:"H+";2:cpd11621:0:0:"Oxidizedferredoxin";2:cpd00005:0:0:"NADPH";1:cpd00003:0:0:"NAD"	[SW] New Reaction. Electron-Bifurcating Enzyme Complex (see reference). Direction in physiological direction. Nfn	Shuning Wang, Haiyan Huang, Johanna Moll, Rudolf K. Thauer (2010) Journal of Bacteriology		NfnAB	Coupled NADP reduction via ferredoxin and NADH (Nfn)	
									
rxn90019	>		-1:cpd00001:0:0:"H2O";-1:cpd00002:0:0:"ATP";-1:cpd00393:1:0:"Folate";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate";1:cpd00067:0:0:"H+";1:cpd00393:0:0:"Folate"	[SW] New reaction for ABC-Transporter for folate (3.a.1.28.2)			Fol-ABC-tr	folate ABC transporter	
rxn90020	>		-1:cpd00001:0:0:"H2O";-1:cpd00002:0:0:"ATP";-1:cpd00557:1:0:"Siroheme";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate";1:cpd00557:0:0:"Siroheme";1:cpd00067:0:0:"H+"	[SW] New reaction for ABC-Transporter for siroheme			Siroheme-ABC-tr	Siroheme transport via ABC system	
									
rxn90021	>		-0.5:cpd00007:0:0:"O2";-2:cpd00067:0:0:"H+";-1:cpd15353:0:0:"2-Demethylmenaquinol 8";1:cpd00001:0:0:"H2O";2:cpd00067:1:0:"H+";1:cpd15352:0:0:"2-Demethylmenaquinone 8"	[SW] New reaction for 7.1.1.5 with 2-Demethylmenaquinone 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-12164		CYTBD2pp-demetylmena	cytochrome oxidase bd (2-Demethylmenaquinol-8: 2 protons) (periplasm)	
rxn90022	=		-1:cpd00178:0:0:"Acetone";1:cpd00178:1:0:"Acetone"	[SW] Acetone diffusion reaction	PMID: 19872448		ACETONE-diffusion	Acetone diffusion	
rxn90023	=		-1:cpd01618:0:0:"1,3-Propanediol";1:cpd01618:1:0:"1,3-Propanediol"						
rxn90024	>		-3:cpd00001:0:0:"H2O";-1:cpd11976:0:0:"Maltodextrin";4:cpd00027:0:0:"D-Glucose"	[JZ] Maltodoxtin and dextrin are not consistently distinghuised, but the maltodextrin glucosidase should also work with maltodextrin. Adopted the stoichiomotry from rxn09989 to be consistent with the sum formula of maltodextrin cpd11976	https://www.uniprot.org/uniprot/P21517		MLTG	maltodextrin glucosidase	
									
									
rxn90025	>		-1:cpd00002:0:0:"ATP";-1:cpd00832:0:0:"N-Acetyl-D-chondrosamine";1:cpd00008:0:0:"ADP";1:cpd03812:0:0:"N-Acetyl-alpha-D-galactosamine 6-phosphate"	[JZ] Added reaction for n-acetyl galactosamine kinase	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-13547		RXN-13547	n-acetyl galactosamine kinase	
rxn90026	>		-1:cpd00001:1:0:"H2O";-1:cpd11842:1:0:"core3";1:cpd00122:1:0:"acgam";1:cpd21520:1:0:"Tn_antigen"	[JZ] Mucus o-glycan degradation, imported from vmh	https://www.vmh.life/#reaction/GLCNACASE_OGLYCAN6e		GLCNACASE_OGLYCAN6e	N-acetylglucosaminidase, extracellular	
rxn90027	>		-1:cpd00001:1:0:"H2O";-1:cpd02992:1:0:"core4";1:cpd00122:1:0:"acgam";1:cpd11842:1:0:"core3"	[JZ] Mucus o-glycan degradation, imported from vmh	https://www.vmh.life/#reaction/GLCNACASE_OGLYCAN5e		GLCNACASE_OGLYCAN5e	N-acetylglucosaminidase, extracellular	
rxn90028	>		-1:cpd00001:1:0:"H2O";-1:cpd21520:1:0:"Tn_antigen";1:cpd00832:1:0:"acgal";1:cpd90017:1:0:"Protein-Linked Serine Or Threonine Residue (O-Glycosylation Site)"	[JZ] Mucus o-glycan degradation, imported from vmh NOT BALANCED! (tmp: ser-thr protein residue missing) [SW] Added missing part	https://www.vmh.life/#reaction/GALNACASE_OGLYCAN1e		GALNACASE_OGLYCAN1e	N-acetylglucosaminidase, extracellular	
									
rxn90029	>		-1:cpd00004:0:0:"NADH";-1:cpd00663:0:0:"Acrylyl-CoA";1:cpd00003:0:0:"NAD";1:cpd00086:0:0:"Propionyl-CoA"	[SW] Reaction for 1.3.1.95 ( acrylate pathway )	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-5494		Acryl-coa-nadh-red	acryloyl-CoA reductase	
									
rxn90030	=		-1:cpd00118:1:0:"Putrescine";-1:cpd00152:0:0:"Agmatine";1:cpd00118:0:0:"Putrescine";1:cpd00152:1:0:"Agmatine"	[SW] Agmatine-Putrescine antiporter as found in En. faecalis	DOI: 10.1126/sciadv.aat0062 		Agm-ptrc-anitport	agmatine-putrescine antiporter 	
									
rxn35560	>		-1:cpd00001:0:0:"H2O";-1:cpd01354:0:0:"beta-Lactose";1:cpd00108:0:0:"Galactose";1:cpd00027:0:0:"D-Glucose"	[SW] Important for Lacto-N-tetraose degradatiion					
rxn22385				[SW] Important for Rhmanose degradatiion without phosphorylated intermediates.					TRUE
rxn22386				[SW] Important for Rhmanose degradatiion without phosphorylated intermediates.					TRUE
rxn39175				[SW] Diffusion of butanol					TRUE
rxn36810				[SW] EC 1.6.5.3					TRUE
rxn26477			-1:cpd00001:0:0:"H2O";-1:cpd08615:0:0:"1-Hydroxy-2-methyl-2-butenyl 4-diphosphate";-2:cpd11621:0:0:"Oxidizedferredoxins";2:cpd00067:0:0:"H+";1:cpd08301:0:0:"2-C-methyl-D-erythritol2-4-cyclodiphosphate";2:cpd11620:0:0:"Reducedferredoxins"						TRUE
rxn26102			-1:cpd15484:0:0:"heptosyl-heptosyl-kdo2-lipidA";-1:cpd00026:0:0:"UDP-glucose";1:cpd00014:0:0:"UDP";1:cpd26538:0:0:"glucosyl-(heptosyl)2-Kdo2-lipid A"	[??] (no comment before) [SW] corrected mass and charge balance and replaced identfier of UDP-glucose with the correct one.					TRUE
rxn16823									TRUE
rxn23042									TRUE
									
rxn47796	>		-3:cpd00007:0:0:"O2";-1:cpd02083:0:0:"CoproporphyrinogenIII";3:cpd00025:0:0:"H2O2";1:cpd03418:0:0:"Coproporphyrin III"	[SW] Added from newer Version from ModelSEED Database (24.6.2019). Direction according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7766		RXN-17517	coproporphyrinogen III oxidase (coproporphyrin-forming) 	
rxn46036	>		-1:cpd03418:0:0:"Coproporphyrin III";-1:cpd10515:0:0:"Fe2+";2:cpd00067:0:0:"H+";1:cpd32319:0:0:"Fe-coproporphyrin III"	[SW] Added from newer Version from ModelSEED Database (24.6.2019). Direction according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7766		coproporphyrin ferrochelatase	coproporphyrin ferrochelatase	
rxn41718	>		-2:cpd00025:0:0:"H2O2";-2:cpd00067:0:0:"H+";-1:cpd32319:0:0:"Fe-coproporphyrin III";4:cpd00001:0:0:"H2O";2:cpd00011:0:0:"CO2";1:cpd00028:0:0:"Heme"	[SW] Added from newer Version from ModelSEED Database (24.6.2019). Direction according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7766		RXN-17519	hydrogen peroxide-dependent heme synthase 	
									
rxn29966			-1:cpd00001:0:0:"H2O";-1:cpd00007:0:0:"O2";-1:cpd03161:0:0:"Phenethylamine";1:cpd00025:0:0:"H2O2";1:cpd00464:0:0:"alpha-Tolualdehyde";1:cpd00013:0:0:"Ammonium"	[JZ] not accessed until now, but needed for phenylethylamine degradation					TRUE
rxn25164				[SW] not accessed until now, but needed for succinate fermentation to butyrate	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-5677				TRUE
									
rxn20632	>		-2:cpd00001:0:0:"H2O";-1:cpd11632:0:0:"hn";-2:cpd27797:0:0:"PLASTOQUINONE";-4:cpd00067:0:0:"H+";1:cpd00007:0:0:"O2";2:cpd27796:0:0:"PLASTOQUINOL-1";4:cpd00067:1:0:"H+"	[JZ] photosystem2 wrong direction + proton missing on both sides (was balanced but no proton pumping) + set photon uptake to 1	https://biocyc.org/META/NEW-IMAGE?type=EC-NUMBER&object=EC-1.10.3.9				
rxn20633		TRUE		[JZ] duplicate to rxn20632					
rxn37614				[JZ] photosystem					TRUE
rxn20595	>		-2:cpd27746:0:0:"Oxidized-Plastocyanins";-1:cpd27796:0:0:"PLASTOQUINOL-1";-2:cpd00067:0:0:"H+";1:cpd27797:0:0:"PLASTOQUINONE";2:cpd27884:0:0:"Plastocyanin-Reduced";4:cpd00067:1:0:"H+"	[JZ] Should be irreversible + proton missing on both sides (was balanced but no proton pumping)	https://metacyc.org/META/NEW-IMAGE?type=EC-NUMBER&object=EC-7.1.1.6				
rxn37613	>			[JZ] photosystem [SW] Corrected direction	https://metacyc.org/META/NEW-IMAGE?type=EC-NUMBER&object=EC-7.1.1.6				TRUE
									
rxn11995	>			[SW] Corrected direction	https://metacyc.org/META/NEW-IMAGE?type=EC-NUMBER&object=EC-7.1.1.6				
rxn12059	>			[SW] Corrected direction	https://metacyc.org/META/NEW-IMAGE?type=EC-NUMBER&object=EC-7.1.1.6				
									
rxn31154				[JZ] photons crossing cell boundaries					TRUE
rxn25456				[SW] Reactions for 2-demethylmenaquinol-6					TRUE
rxn36796				[SW] Reactions for 2-demethylmenaquinol-6					TRUE
rxn36797				[SW] Reactions for 2-demethylmenaquinol-6					TRUE
rxn36872				[SW] Reactions for 2-demethylmenaquinol-6					TRUE
rxn36873				[SW] Reactions for 2-demethylmenaquinol-6					TRUE
rxn16371				[SW] Reaction required for a coenzyme M biosynthesis pathway					TRUE
rxn26754	>		-1:cpd11632:0:0:"hn";-1:cpd11621:0:0:"Oxidizedferredoxin";-1:cpd27884:0:0:"Plastocyanin-Reduced";1:cpd27746:0:0:"Oxidized-Plastocyanins";1:cpd11620:0:0:"Reducedferredoxin"	[JZ] photosystem1 should be irreversible + adapted to use default identifier for ferredoxin (cpd11620/cpd11621)	https://biocyc.org/META/NEW-IMAGE?type=EC-NUMBER&object=EC-1.97.1.12				
rxn26755		TRUE		[JZ] duplicate to rxn26754					
rxn17196	>		-1:cpd00006:0:0:"NADP";-1:cpd00067:0:0:"H+";-2:cpd11620:0:0:"Reducedferredoxins";1:cpd00005:0:0:"NADPH";2:cpd11621:0:0:"Oxidizedferredoxins"	[JZ] wrong direction; [SW] changed even to only forward and changed ferrdoxin identifiers	https://biocyc.org/META/NEW-IMAGE?type=EC-NUMBER&object=EC-1.18.1.2				
rxn11969		TRUE		[JZ] non-enzymatic animal retina reaction in wrong direction					
rxn11981	>			[JZ] Vitamin D3 formation needs light					
rxn11990	>			[JZ] Vitamin D2 formation needs light					
rxn00072			-2:cpd00001:0:0:"H2O";-1:cpd00003:0:0:"NAD";-2:cpd00423:0:0:"Vitamin B12r";-1:cpd00067:0:0:"H+";1:cpd00004:0:0:"NADH";2:cpd00730:0:0:"Aquacobalamin"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn00080			-1:cpd00005:0:0:"NADPH";-2:cpd00730:0:0:"Aquacobalamin";2:cpd00001:0:0:"H2O";1:cpd00006:0:0:"NADP";2:cpd00423:0:0:"Vitamin B12r";1:cpd00067:0:0:"H+"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn02151			-1:cpd00006:0:0:"NADP";-1:cpd00150:0:0:"HCN";-1:cpd00635:0:0:"Cbl";1:cpd00005:0:0:"NADPH";1:cpd01826:0:0:"Dicopac"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn07483			-1:cpd00635:0:0:"Cbl";-1:cpd04073:0:0:"Vanillate";-1:cpd00067:0:0:"H+";1:cpd00197:0:0:"Protocatechuate";1:cpd12878:0:0:"Methylcobalamin"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn10091			-1:cpd00001:0:0:"H2O";-1:cpd00002:0:0:"ATP";-1:cpd00635:0:0:"Cbl";1:cpd00009:0:0:"Phosphate";1:cpd00012:0:0:"PPi";1:cpd00067:0:0:"H+";1:cpd00166:0:0:"Calomide"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn10452		TRUE		[SW] incomplete reaction					
rxn11649			-1:cpd00730:0:0:"Aquacobalamin";-1:cpd03871:0:0:"2-Hydroxypropylphosphonate";1:cpd00001:0:0:"H2O";1:cpd02024:0:0:"Phosphonoacetaldehyde";1:cpd12878:0:0:"Methylcobalamin"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn00104			-1:cpd00002:0:0:"ATP";-1:cpd00012:0:0:"PPi";1:cpd00008:0:0:"ADP";1:cpd00421:0:0:"Triphosphate"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn01352			-1:cpd00001:0:0:"H2O";-1:cpd00241:0:0:"dGTP";1:cpd00277:0:0:"Deoxyguanosine";1:cpd00421:0:0:"Triphosphate";1:cpd00067:0:0:"H+"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn01813	>		-1:cpd00001:0:0:"H2O";-1:cpd01622:0:0:"Trimetaphosphate";1:cpd00421:0:0:"Triphosphate";1:cpd00067:0:0:"H+"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn03535			-1:cpd00002:0:0:"ATP";-1:cpd03915:0:0:"Cob(I)yrinate diamide";1:cpd00421:0:0:"Triphosphate";1:cpd03916:0:0:"Adenosyl cobyrinate diamide"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn05029			-1:cpd00002:0:0:"ATP";-1:cpd03422:0:0:"Cobinamide";1:cpd00421:0:0:"Triphosphate";1:cpd03918:0:0:"Adenosyl cobinamide"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn10052			-1:cpd00067:0:0:"H+";-1:cpd00018:0:0:"AMP";-1:cpd00421:0:0:"Triphosphate";1:cpd00008:0:0:"ADP";1:cpd00012:0:0:"PPi"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn10451			-1:cpd00002:0:0:"ATP";-1:cpd15837:0:0:"Cob(I)alamin-HBI";1:cpd00421:0:0:"Triphosphate";1:cpd15834:0:0:"Adenosylcobalamin-HBI"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn13519			-1:cpd00027:0:0:"D-Glucose";-1:cpd00421:0:0:"Triphosphate";1:cpd00012:0:0:"PPi";1:cpd00067:0:0:"H+";1:cpd00079:0:0:"D-glucose-6-phosphate"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn03537			-1:cpd00038:0:0:"GTP";-1:cpd03919:0:0:"Adenosyl cobinamide phosphate";1:cpd00012:0:0:"PPi";1:cpd03920:0:0:"Adenosylcobinamide-GDP"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn10429			-1:cpd03920:0:0:"Adenosylcobinamide-GDP";-1:cpd15903:0:0:"N1-(alpha-D-ribosyl)-5-hydroxybenzimidazole";1:cpd00067:0:0:"H+";1:cpd00126:0:0:"GMP";1:cpd15834:0:0:"Adenosylcobalamin-HBI"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn00299			-1:cpd00001:0:0:"H2O";-1:cpd00038:0:0:"GTP";1:cpd00047:0:0:"Formate";2:cpd00067:0:0:"H+";1:cpd02978:0:0:"7,8-Dihydroneopterin 3'-triphosphate"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn03167			-3:cpd00001:0:0:"H2O";-1:cpd02978:0:0:"7,8-Dihydroneopterin 3'-triphosphate";3:cpd00009:0:0:"Phosphate";2:cpd00067:0:0:"H+";1:cpd02961:0:0:"Dihydroneopterin"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn03173			-1:cpd00001:0:0:"H2O";-1:cpd02978:0:0:"7,8-Dihydroneopterin 3'-triphosphate";1:cpd00012:0:0:"PPi";1:cpd00067:0:0:"H+";1:cpd03521:0:0:"Dihydroneopterin phosphate"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn03542			-1:cpd00001:0:0:"H2O";-1:cpd00002:0:0:"ATP";-1:cpd00149:0:0:"Co2+";-1:cpd03913:0:0:"Hydrogenobyrinate diamide";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate";5:cpd00067:0:0:"H+";1:cpd03914:0:0:"Cob(II)yrinate diamide"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
rxn00302			-1:cpd00001:0:0:"H2O";-1:cpd00038:0:0:"GTP";1:cpd03518:0:0:"Formamidopyrimidine nucleoside triphosphate";1:cpd00067:0:0:"H+"	[SW] proton balance due to update formula of cpd00423 and cpd00635					
									
rxn04959		TRUE							
rxn11779			-1:cpd00001:0:0:"H2O";-1:cpd04344:0:0:"Isoniazid";1:cpd03177:0:0:"Hydrazine";1:cpd04623:0:0:"Isonicotinic acid";1:cpd00067:0:0:"H+"						
rxn12218			-1:cpd10515:0:0:"Fe2+";-1:cpd01476:0:0:"Protoporphyrin";1:cpd00028:0:0:"Heme";2:cpd00067:0:0:"H+"						
rxn12221			-1:cpd10515:0:0:"Fe2+";-1:cpd03426:0:0:"Sirohydrochlorin";2:cpd00067:0:0:"H+";1:cpd00557:0:0:"Siroheme"						
rxn13831			-1:cpd00001:0:0:"H2O";-1:cpd00002:0:0:"ATP";-1:cpd10515:1:0:"Fe2+";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate";1:cpd10515:0:0:"Fe2+";1:cpd00067:0:0:"H+"						
									
rxn12972		TRUE							
rxn13056		TRUE							
									
rxn05880		TRUE		[JZ] unbalanced and placeholder metabolite					
									
rxn12413		TRUE		[JZ] strange definition: symporter with protons from e0 compartment and cytodine from p0 (normal definition of cytidine proton symporter: rxn05198)					
									
rxn21460	>		-1:cpd00418:0:0:"NO";-1:cpd00013:0:0:"NH4+";-3:cpd00110:0:0:"Cytochrome c2+";-2:cpd00067:0:0:"H+";1:cpd00001:0:0:"H2O";1:cpd03177:0:0:"Hydrazine";3:cpd00109:0:0:"Cytochrome c3+"	[JZ] important reaction for anaerobic ammonia oxidation, was only with abstract electron acceptor + unbalanced protons	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11175		RXN-11175	Hydrazine synthase	
rxn90031	>		-1:cpd00418:0:0:"NO";-1:cpd00013:0:0:"NH4+";-3:cpd11798:0:0:"Ferrocytochrome c2";-2:cpd00067:0:0:"H+";1:cpd00001:0:0:"H2O";1:cpd03177:0:0:"Hydrazine";3:cpd11796:0:0:"Ferricytochrome c2"	[JZ] important reaction for anaerobic ammonia oxidation, new reaction with different cytochrome c type	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11175		RXN-11175	Hydrazine synthase	
rxn17267	>		-1:cpd03177:0:0:"Hydrazine";-4:cpd00109:0:0:"Cytochrome c3+";1:cpd00528:0:0:"N2";4:cpd00110:0:0:"Cytochrome c2+";4:cpd00067:1:0:"H+"	[JZ] important reaction for anaerobic ammonia oxidation, was only with abstract electron acceptor + unbalanced protons	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.7.99.8-RXN		1.7.99.8-RXN	Hydrazine dehydrogenase	
rxn90032	>		-1:cpd03177:0:0:"Hydrazine";-4:cpd11796:0:0:"Ferricytochrome c2";1:cpd00528:0:0:"N2";4:cpd11798:0:0:"Ferrocytochrome c2";4:cpd00067:1:0:"H+"				1.7.99.8-RXN	Hydrazine dehydrogenase	
									
rxn13745		TRUE		[JZ] unclear sulfite reductase with quinone, no reference found, shuffles proton to periplasm => suspicious (see rxn05902, rxn00623 for sulfite reductases)					
rxn13746		TRUE		[JZ] unclear sulfite reductase with quinone, no reference found, shuffles proton to periplasm => suspicious (see rxn05902, rxn00623 for sulfite reductases)					
rxn04045	>		-1:cpd00149:0:0:"Co2+";-1:cpd01620:0:0:"Precorrin 2";3:cpd00067:0:0:"H+";1:cpd08368:0:0:"Cobalt-precorrin 2"	[SW] Corrected according to RHEA	https://www.rhea-db.org/reaction?id=26269		Co-Chelatase	Cobaltochelatase	
									
rxn90033	>		-1:cpd90003:1:0:"starch (n=27, 3xalpha1-6, 23xalpha1-4)";-4:cpd00001:1:0:"H2O";1:cpd90004:1:0:"starch (n=19, 3xalpha1-6, 15xalpha1-4)";4:cpd00179:1:0:"Maltose"	[SW] new reactions for extracellular starch degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-842		Beta-amylase-starch27	beta-amylase (exo, acting on 4 maltose residues at non-reducing end)	
rxn90034	>		-1:cpd90008:1:0:"Maltotridecaose";-6:cpd00001:1:0:"H2O";6:cpd00179:1:0:"Maltose";1:cpd00027:1:0:"D-Glucose"	[SW] new reactions for extracellular starch degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-842		Amylase-malt13	alpha or beta glcosidase (acting on maltotridecaose)	
rxn90035	>		-1:cpd90005:1:0:"Maltooctaose";-3:cpd00001:1:0:"H2O";4:cpd00179:1:0:"Maltose"	[SW] new reactions for extracellular starch degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-842		Amylase-malt8	alpha or beta glcosidase (acting on maltooctaose)	
rxn90036	>		-1:cpd90007:1:0:"Maltohexaose";-2:cpd00001:1:0:"H2O";3:cpd00179:1:0:"Maltose"	[SW] new reactions for extracellular starch degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-842		Amylase-malt6	alpha or beta glcosidase (acting on maltohexose)	
rxn90037	>		-1:cpd90006:1:0:"Maltoundecaose";-5:cpd00001:1:0:"H2O";5:cpd00179:1:0:"Maltose";1:cpd00027:1:0:"D-Glucose"	[SW] new reactions for extracellular starch degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-842		Amylase-malt11	alpha or beta glcosidase (acting on maltoundecaose)	
rxn90038	>		-1:cpd90003:1:0:"starch (n=27, 3xalpha1-6, 23xalpha1-4)";-26:cpd00001:1:0:"H2O";27:cpd00027:1:0:"D-Glucose"	[SW] new reactions for extracellular starch degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-842		Gamma-amylase-starch27	gamma-amylase (exo, acting on n=27 starch)	
rxn90039	>		-1:cpd90008:1:0:"Maltotridecaose";-12:cpd00001:1:0:"H2O";13:cpd00027:1:0:"D-Glucose"	[SW] new reactions for extracellular starch degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-842		Gamma-amylase-malt13	gamma-amylase (exo, acting on maltotridecaose)	
rxn90040	>		-1:cpd90006:1:0:"Maltoundecaose";-10:cpd00001:1:0:"H2O";11:cpd00027:1:0:"D-Glucose"	[SW] new reactions for extracellular starch degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-842		Gamma-amylase-malt11	gamma-amylase (exo, acting on Maltoundecaose)	
rxn90041	>		-1:cpd90005:1:0:"Maltooctaose";-7:cpd00001:1:0:"H2O";8:cpd00027:1:0:"D-Glucose"	[SW] new reactions for extracellular starch degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-842		Gamma-amylase-malt8	gamma-amylase (exo, acting on Maltooctaose)	
rxn90042	>		-1:cpd90007:1:0:"Maltohexaose";-5:cpd00001:1:0:"H2O";6:cpd00027:1:0:"D-Glucose"	[SW] new reactions for extracellular starch degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-842		Gamma-amylase-malt6	gamma-amylase (exo, acting on Maltohexaose)	
rxn90043	>		-1:cpd90003:1:0:"starch (n=27, 3xalpha1-6, 23xalpha1-4)";-3:cpd00001:1:0:"H2O";1:cpd90005:1:0:"Maltooctaose";1:cpd90008:1:0:"Maltotridecaose";2:cpd01262:1:0:"Amylotriose"	[SW] new reactions for extracellular starch degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-842		Pullulanase-starch27	Pullulanase (exo, acting on n27-Starch with 3 alpha1-4 bonds)	
rxn90044	>		-1:cpd90004:1:0:"starch (n=19, 3xalpha1-6, 15xalpha1-4)";-3:cpd00001:1:0:"H2O";1:cpd90007:1:0:"Maltohexaose";1:cpd90006:1:0:"Maltoundecaose";2:cpd00027:1:0:"D-Glucose"	[SW] new reactions for extracellular starch degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-842		Pullulanase-starch19	Pullulanase (exo, acting on n19-Starch with 3 alpha1-4 bonds)	
rxn90045	>		-1:cpd90004:1:0:"starch (n=19, 3xalpha1-6, 15xalpha1-4)";-18:cpd00001:1:0:"H2O";19:cpd00027:1:0:"D-Glucose"	[SW] new reactions for extracellular starch degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-842		Gamma-amylase-starch19	gamma-amylase (exo, acting on n=19 starch)	
									
rxn07043	>		-1:cpd12777:1:0:"Galactan";-1:cpd00001:1:0:"H2O";2:cpd00108:1:0:"Galactose"	[SW] corrected exo-beta-1,3-galactanase	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.2.1.145-RXN				
									
rxn11066		TRUE		[SW] model specific reactions					
rxn11072		TRUE		[SW] model specific reactions					
rxn11073		TRUE		[SW] model specific reactions					
rxn11074		TRUE		[SW] model specific reactions					
rxn11075		TRUE		[SW] model specific reactions					
rxn11076		TRUE		[SW] model specific reactions					
rxn11094		TRUE		[SW] model specific reactions					
rxn11108		TRUE		[SW] model specific reactions					
rxn11109		TRUE		[SW] model specific reactions					
rxn11120		TRUE		[SW] model specific reactions					
rxn11125		TRUE		[SW] model specific reactions					
rxn11136		TRUE		[SW] model specific reactions					
rxn11141		TRUE		[SW] model specific reactions					
rxn11145		TRUE		[SW] model specific reactions					
rxn11164		TRUE		[SW] model specific reactions					
rxn11168		TRUE		[SW] model specific reactions					
rxn11169		TRUE		[SW] model specific reactions					
rxn11170		TRUE		[SW] model specific reactions					
rxn11171		TRUE		[SW] model specific reactions					
rxn11172		TRUE		[SW] model specific reactions					
rxn11179		TRUE		[SW] model specific reactions					
rxn11181		TRUE		[SW] model specific reactions					
rxn11192		TRUE		[SW] model specific reactions					
rxn11193		TRUE		[SW] model specific reactions					
rxn11194		TRUE		[SW] model specific reactions					
rxn11195		TRUE		[SW] model specific reactions					
rxn07461		TRUE		[SW] generic reaction.					
rxn07866		TRUE		[SW] generic reaction.					
rxn07867		TRUE		[SW] generic reaction.					
rxn29825		TRUE		[SW] generic reaction.					
rxn16316		TRUE		[SW] generic reaction.					
rxn12360		TRUE		[SW] model specific reactions					
rxn11967		TRUE		[SW] Unbalanced and generic reaction.					
rxn09589		TRUE		[SW] generic reaction.					
rxn09590		TRUE		[SW] generic reaction.					
rxn09591		TRUE		[SW] generic reaction.					
rxn09592		TRUE		[SW] generic reaction.					
rxn09593		TRUE		[SW] generic reaction.					
									
rxn05330			-1:cpd11479:0:0:"D-3-Hydroxyhexanoyl-[acp]";1:cpd00001:0:0:"H2O";1:cpd11473:0:0:"(2E)-Hexenoyl-[acp]"	[SW] reactions repaired					
rxn05332			-1:cpd11481:0:0:"R-3-hydroxypalmitoyl-acyl-carrierprotein-";1:cpd00001:0:0:"H2O";1:cpd11477:0:0:"(2E)-Hexadecenoyl-[acp]"	[SW] reactions repaired					
rxn05333			-1:cpd11482:0:0:"(R)-3-Hydroxydecanoyl-[acyl-carrier protein]";1:cpd00001:0:0:"H2O";1:cpd11475:0:0:"(2E)-Decenoyl-[acp]"	[SW] reactions repaired					
rxn05335			-1:cpd11484:0:0:"(R)-3-Hydroxytetradecanoyl-[acyl-carrier-protein]";1:cpd00001:0:0:"H2O";1:cpd11467:0:0:"(2E)-Tetradecenoyl-[acp]"	[SW] reactions repaired					
rxn06229			-2:cpd00067:0:0:"H+";-1:cpd00007:0:0:"O2";-1:cpd00237:0:0:"Androstenedione";-2:cpd11723:0:0:"Reduced adrenodoxin";1:cpd00001:0:0:"H2O";1:cpd03135:0:0:"4-Androsten-11beta-ol-3,17-dione";2:cpd11724:0:0:"Oxidized adrenodoxin"	[SW] stoichiometry and balance corrected					
rxn06230			-2:cpd00067:0:0:"H+";-1:cpd00007:0:0:"O2";-1:cpd11661:0:0:"Steroid";-2:cpd11723:0:0:"Reduced adrenodoxin";1:cpd00001:0:0:"H2O";2:cpd11724:0:0:"Oxidized adrenodoxin";1:cpd11805:0:0:"11beta-Hydroxysteroid"	[SW] stoichiometry and balance corrected					
									
rxn13836	>		-1:cpd00001:0:0:"H2O";-1:cpd00170:0:0:"Gluconolactone";1:cpd00067:0:0:"H+";1:cpd00222:0:0:"GLCN"	[SW] Corrected metabolite compartments.	https://metacyc.org/META/NEW-IMAGE?object=GLUCONOLACT-RXN				
									
rxn13666		TRUE		[SW] aggregate reactions. Dead end metabolite					
rxn13668		TRUE		[SW] aggregate reactions. Dead end metabolite					
rxn13672		TRUE		[SW] aggregate reactions. Dead end metabolite					
rxn10201		TRUE		[SW] model specific reaction					
rxn11508		TRUE		[SW] generic reaction.					
rxn06800		TRUE		[SW] incomplete reaction					
rxn06320		TRUE		[SW] generic reaction.					
rxn07244		TRUE		[SW] generic reaction.					
rxn07245		TRUE		[SW] generic reaction.					
									
rxn06351			-2:cpd00067:0:0:"H+";-1:cpd00007:0:0:"O2";-1:cpd01450:0:0:"Corticosterone";-2:cpd11723:0:0:"Reduced adrenodoxin";1:cpd00001:0:0:"H2O";1:cpd00827:0:0:"18-Hydroxycorticosterone";2:cpd11724:0:0:"Oxidized adrenodoxin"	[SW] Corrected according to RHEA	https://www.rhea-db.org/reaction?id=15629				
rxn06670			-1:cpd00003:0:0:"NAD";-1:cpd02386:0:0:"2-Dehydro-3-deoxy-D-xylonate";1:cpd00004:0:0:"NADH";1:cpd12723:0:0:"(4S)-5-Hydroxy-2,4-dioxopentanoate";1:cpd00067:0:0:"H+"	[SW] re-balanced.					
rxn07110			-1:cpd08926:0:0:"Phytosphingosine";-1:cpd13404:0:0:"C26-CoA";1:cpd00010:0:0:"CoA";1:cpd08927:0:0:"Ceramide II";1:cpd00067:0:0:"H+"	[SW] re-balanced.					
rxn13449			-1:cpd00906:0:0:"all-trans-Hexaprenyl diphosphate";-1:cpd02295:0:0:"1-4-Dihydroxy-2-naphthoate";1:cpd00011:0:0:"CO2";1:cpd00012:0:0:"PPi";1:cpd23248:0:0:"DMKH2-6"	[SW] main product, stoichiometry and balanced and corrected					
rxn10845	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-5849		2-DMKH2-6-C3trans	2-demethylmenaquinone 6 methyltransferase	
rxn08333	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DMK-RXN				
rxn16215	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-10056&&detail-level=2				
rxn20835	<		-1:cpd00334:0:0:"L-Lactaldehyde";-1:cpd00649:0:0:"Coenzyme F420-2";1:cpd00428:0:0:"2-Oxopropanal";1:cpd00792:0:0:"Reduced coenzyme F420-2"	[SW] replace F420 factor ID	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-10064&&detail-level=3				
rxn20828				[SW] required for lactate biosynthesis in archaea	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-10054&&detail-level=3				TRUE
rxn24594				[SW] required for lactate biosynthesis in archaea	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-8075&&detail-level=3				TRUE
									
rxn90046	>		-1:cpd00061:0:0:"Phosphoenolpyruvate";-1:cpd00832:1:0:"N-Acetyl-D-chondrosamine";-1:cpd00067:0:0:"H+";1:cpd03812:0:0:"N-Acetyl-D-galactosamine 6-phosphate";1:cpd00020:0:0:"Pyruvate"	[JZ] New reaction for PTS-Transporter for n-acetyl galactosamine	https://www.vmh.life/#reaction/ACGALpts		ACGALpts	N acetylgalactosamine via PTS	
rxn90047	>		-1:cpd00002:0:0:"ATP";-1:cpd00159:0:0:"L-Lactate";1:cpd00008:0:0:"ADP";1:cpd20414:0:0:"(2S)-2-Phospholactate";1:cpd00067:0:0:"H+"	[SW] Putative reaction. Required for F420 de novo biosynthesis in Archaea	doi: 10.1128/JB.188.8.2836-2844.2006		Lac-kin	L-lactate kinase	
rxn90048	>		-1:cpd00001:0:0:"H2O";-1:cpd90009:0:0:"[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-(4-aminophenyl)-1-deoxy-D-ribitol 5'-phosphate";1:cpd90010:0:0:"[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-(4-aminophenyl)-1-deoxy-D-ribitol";1:cpd00009:0:0:"Phosphate"	[SW] reaction required for h4spt biosynthesis	RXN-10011		[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-(4-aminophenyl)-1-deoxy-D-ribitol 5'-phosphate phosphatase	[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-(4-aminophenyl)-1-deoxy-D-ribitol 5'-phosphate phosphatase	
rxn90049	>		-1:cpd90010:0:0:"[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-(4-aminophenyl)-1-deoxy-D-ribitol";-1:cpd00103:0:0:"PRPP";1:cpd90011:0:0:"[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-(4-aminophenyl)-1-deoxy-5-[1-alpha-D-ribofuranosyl 5-phosphate]-D-ribitol";1:cpd00012:0:0:"PPi";1:cpd00067:0:0:"H+"	[SW] reaction required for h4spt biosynthesis	RXN-10012		[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-(4-aminophenyl)-1-deoxy-D-ribitol ribosyltransferase	[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-(4-aminophenyl)-1-deoxy-D-ribitol ribosyltransferase	
rxn90050	>		-1:cpd00002:0:0:"ATP";-1:cpd90011:0:0:"[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-(4-aminophenyl)-1-deoxy-5-[1-alpha-D-ribofuranosyl 5-phosphate]-D-ribitol";1:cpd90012:0:0:"[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-(4-aminophenyl)-1-deoxy-5-[1-alpha-D-ribofuranosyl triphosphate]-D-ribitol";1:cpd00018:0:0:"AMP";1:cpd00067:0:0:"H+"	[SW] reaction required for h4spt biosynthesis	RXN-10013		[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-(4-aminophenyl)-1-deoxy-5-[1-alpha-D-ribofuranosyl 5-phosphate]-D-ribitol dikinase	[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-(4-aminophenyl)-1-deoxy-5-[1-alpha-D-ribofuranosyl 5-phosphate]-D-ribitol dikinase	
									
rxn43778	<		-1:cpd02246:0:0:"CoM";-1:cpd02817:0:0:"HTP";-2:cpd11621:0:0:"Oxidizedferredoxin";2:cpd11620:0:0:"Reducedferredoxin";3:cpd00067:0:0:"H+";1:cpd02935:0:0:"CoM-S-S-CoB"	[SW] new reaction that corresponds to metacyc reaction RXN-18520	https://metacyc.org/META/NEW-IMAGE?object=RXN-18520		hdr	ferredoxin:CoB-CoM heterodisulfide reductase	
rxn43076	<		-1:cpd02246:0:0:"CoM";-1:cpd02817:0:0:"HTP";-2:cpd11620:0:0:"Reducedferredoxin";-1:cpd00067:0:0:"H+";-2:cpd00649:0:0:"Coenzyme F420-2";2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd02935:0:0:"CoM-S-S-CoB";2:cpd00792:0:0:"Reduced coenzyme F420-2"	[SW] new reaction that corresponds to metacyc reaction RXN-18528 [JZ] proton should be produced in cytosol not periplasm	10.1128/JB.00593-12		Hdr-fx	coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase	
rxn42401	<		-1:cpd02246:0:0:"CoM";-1:cpd02817:0:0:"HTP";-2:cpd11620:0:0:"Reducedferredoxin";-1:cpd00067:0:0:"H+";2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd02935:0:0:"CoM-S-S-CoB";2:cpd11640:0:0:"H2"	[SW] new reaction that corresponds to metacyc reaction RXN-18521	https://metacyc.org/META/NEW-IMAGE?object=RXN-18521		Hdr-h2	H2:CoB-CoM heterodisulfide,ferredoxin reductase	
rxn47799	<		-1:cpd02246:0:0:"CoM";-1:cpd02817:0:0:"HTP";-2:cpd11620:0:0:"Reducedferredoxin";-2:cpd00011:0:0:"CO2";1:cpd00067:0:0:"H+";2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd02935:0:0:"CoM-S-S-CoB";2:cpd00047:0:0:"Formate"	[SW] new reaction that corresponds to metacyc reaction RXN-18529			Hdr-formate	formate:CoB-CoM heterodisulfide,ferredoxin reductase	
rxn43368	>		-1:cpd00017:0:0:"S-Adenosyl-L-methionine";-1:cpd31434:0:0:"5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil";1:cpd00013:0:0:"NH3";1:cpd00060:0:0:"L-Methionine";1:cpd03091:0:0:"5'-Deoxyadenosine";1:cpd15839:0:0:"7,8-didemethyl-8-hydroxy-5-deazariboflavin"	[SW] new reaction that corresponds to metacyc reaction RXN-19230					
rxn42355	>		-1:cpd00017:0:0:"S-Adenosyl-L-methionine";-1:cpd00069:0:0:"L-Tyrosine";-1:cpd02882:0:0:"4--1-D-Ribitylamino-5-aminouracil";1:cpd31434:0:0:"5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil";1:cpd00060:0:0:"L-Methionine";2:cpd00067:0:0:"H+";1:cpd03091:0:0:"5'-Deoxyadenosine";1:cpd14545:0:0:"Iminoglycine"	[SW] new reaction that corresponds to metacyc reaction RXN-19229					
									
rxn44776	<		-2:cpd00067:0:0:"H+";-1:cpd24795:0:0:"pyrrocorphinate";1:cpd00244:0:0:"Ni2+";1:cpd03426:0:0:"Sirohydrochlorin"	[SW] reaction required for factor F430 biosynthesis			Siroh-chlorin-ni	sirohydrochlorin nickelchelatase	
rxn48136	>		-2:cpd00001:0:0:"H2O";-2:cpd00002:0:0:"ATP";-2:cpd00053:0:0:"L-Glutamine";-1:cpd24795:0:0:"pyrrocorphinate";2:cpd00008:0:0:"ADP";2:cpd00009:0:0:"Phosphate";2:cpd00023:0:0:"L-Glutamate";2:cpd00067:0:0:"H+";1:cpd24796:0:0:"dihydrocorphinate"	[SW] reaction required for factor F430 biosynthesis			ni-siroh-2N-syn	Ni-sirohydrochlorin a,c-diamide synthase	
rxn46441	>		-1:cpd00001:0:0:"H2O";-1:cpd00002:0:0:"ATP";-1:cpd24796:0:0:"dihydrocorphinate";-3:cpd00004:0:0:"NADH";-3:cpd00067:0:0:"H+";3:cpd00003:0:0:"NAD";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate";1:cpd24798:0:0:"factor F430 seco-precursor"	[SW] reaction required for factor F430 biosynthesis			ni-siroh-2N-red-cyclase	Ni-sirohydrochlorin a,c-diamide reductive cyclase	
rxn47116	>		-1:cpd00002:0:0:"ATP";-1:cpd24798:0:0:"factor F430 seco-precursor";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate";1:cpd03425:0:0:"Factor F430"	[SW] reaction required for factor F430 biosynthesis			F430syn	coenzyme F430 synthetase 	
rxn44185	>		-1:cpd00067:0:0:"H+";-2:cpd00017:0:0:"S-Adenosyl-L-methionine";-1:cpd00954:0:0:"6-hydroxymethyl dihydropterin";-2:cpd02679:0:0:"5,10-Methylenetetrahydromethanopterin";-1:cpd00004:0:0:"NADH";-2:cpd11620:0:0:"Reducedferredoxin";2:cpd00060:0:0:"L-Methionine";2:cpd03091:0:0:"5'-Deoxyadenosine";2:cpd03523:0:0:"7,8-Dihydromethanopterin";1:cpd00003:0:0:"NAD";2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd34981:0:0:"2-amino-6-[1-hydroxyethyl]-7-methyl-7,8-dihydropterin"	[SW] reaction required for h4spt biosynthesis	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-15732&&detail-level=2		6hm78dpt79dm-trans	6-hydroxymethyl-7,8-dihydropterin 7,9-dimethyltransferase	
rxn45543	>		-1:cpd00002:0:0:"ATP";-1:cpd34981:0:0:"2-amino-6-[1-hydroxyethyl]-7-methyl-7,8-dihydropterin";1:cpd00018:0:0:"AMP";2:cpd00067:0:0:"H+";1:cpd32995:0:0:" [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl diphosphate"	[SW] reaction required for h4spt biosynthesis			2N-4hydroxy-6-hm2hpt-pp	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase 	
rxn46822	>		-1:cpd32995:0:0:" [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl diphosphate";-1:cpd24823:0:0:"4-(beta-D-ribofuranosyl)aminobenzene-5'-phosphate";1:cpd00012:0:0:"PPi";1:cpd32565:0:0:"[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate"	[SW] reaction required for h4spt biosynthesis	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-15734&&detail-level=2		RXN-1573	7,8-dihydropterin-6-yl-methyl-4-(?-D-ribofuranosyl)aminobenzene 5'-phosphate synthase	
rxn46469	>		-1:cpd32711:0:0:"4-(beta-D-ribofuranosyl)-N-succinylaminobenzene 5'-phosphate";1:cpd00106:0:0:"Fumarate";1:cpd24823:0:0:"4-(beta-D-ribofuranosyl)aminobenzene-5'-phosphate"	[SW] reaction required for h4spt biosynthesis	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-15742&&detail-level=2		RXN-15742	4-(beta-D-ribofuranosyl)-N-succinylaminobenzene 5'-phosphate lyase	
rxn44206	>		-1:cpd00002:0:0:"ATP";-1:cpd00041:0:0:"L-Aspartate";-1:cpd31424:0:0:"4-(beta-D-ribofuranosyl)hydroxybenzene 5'-phosphate";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate";2:cpd00067:0:0:"H+";1:cpd32711:0:0:"4-(beta-D-ribofuranosyl)-N-succinylaminobenzene 5'-phosphate"	[SW] reaction required for h4spt biosynthesis	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-15741&&detail-level=2		RXN-15741	4-(beta-D-ribofuranosyl)hydroxybenzene 5'-phosphate ligase	
rxn42137	>		-1:cpd00103:0:0:"PRPP";-1:cpd00136:0:0:"4-Hydroxybenzoate";1:cpd00011:0:0:"CO2";1:cpd00012:0:0:"PPi";1:cpd31424:0:0:"4-(beta-D-ribofuranosyl)hydroxybenzene 5'-phosphate"	[SW] reaction required for h4spt biosynthesis	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-8124&&detail-level=2		beta-ribofuranosylaminobenzene-5'-phosphate synthase	beta-ribofuranosylaminobenzene-5'-phosphate synthase	
									
rxn45700	>		-1:cpd00067:0:0:"H+";-1:cpd00004:0:0:"NADH";-1:cpd32565:0:0:"[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate";1:cpd00003:0:0:"NAD";1:cpd90009:0:0:"[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-(4-aminophenyl)-1-deoxy-D-ribitol 5'-phosphate"	[SW] reaction required for h4spt biosynthesis			[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate dehydrogenase	[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate dehydrogenase	
rxn42782	>		-1:cpd02041:0:0:"(S)-2-Hydroxyglutarate";-1:cpd90012:0:0:"[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-(4-aminophenyl)-1-deoxy-5-[1-alpha-D-ribofuranosyl triphosphate]-D-ribitol";1:cpd00012:0:0:"PPi";1:cpd03523:0:0:"7,8-Dihydromethanopterin"	[SW] reaction required for h4spt biosynthesis			RXN-10014	RXN-10014	
									
rxn46006	>		-1:cpd03920:0:0:"Adenosylcobinamide-GDP";-1:cpd15826:0:0:"N1-(5-Phospho-alpha-D-ribosyl)-5-hydroxybenzimidazole";1:cpd00067:0:0:"H+";1:cpd00126:0:0:"GMP";1:cpd31445:0:0:"Coalpha-[alpha-(5-hydroxybenzimidazolyl)]-Cobeta-adenosylcobamide 5'-phosphate"	[SW] reaction required for adenosyl factor III (Adenosylcobalamin-HBI)	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-19303		adenosylcobinamide-GDP ribazoletransferase	adenosylcobinamide-GDP ribazoletransferase	
rxn48494	>		-1:cpd00001:0:0:"H2O";-1:cpd31445:0:0:"Coalpha-[alpha-(5-hydroxybenzimidazolyl)]-Cobeta-adenosylcobamide 5'-phosphate";1:cpd00009:0:0:"Phosphate";1:cpd33626:0:0:"adenosyl factor III"	[SW] reaction required for adenosyl factor III (Adenosylcobalamin-HBI)	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-19320		adenosylcobalamin/?-ribazole phosphatase	adenosylcobalamin/?-ribazole phosphatase	
rxn41668	>		-1:cpd00017:0:0:"S-Adenosyl-L-methionine";-1:cpd02140:0:0:"AIR";-1:cpd00004:0:0:"NADH";1:cpd00009:0:0:"Phosphate";1:cpd00013:0:0:"NH3";1:cpd00047:0:0:"Formate";1:cpd00060:0:0:"L-Methionine";1:cpd00067:0:0:"H+";1:cpd03091:0:0:"5'-Deoxyadenosine";1:cpd00003:0:0:"NAD";1:cpd15825:0:0:"5-hydroxybenzimidazole"	[SW] reaction required for adenosyl factor III (Adenosylcobalamin-HBI)	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-17122		5-hydroxybenzimidazole synthase	5-hydroxybenzimidazole synthase	
rxn10582	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-19299				
rxn10450			-1:cpd00001:0:0:"H2O";-1:cpd00002:0:0:"ATP";-1:cpd33626:1:0:"adenosyl factor III";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate";1:cpd00067:0:0:"H+";1:cpd33626:0:0:"adenosyl factor III"	[SW] Replaced ID of deprecated version of Ade-Cobalamin-HBI					
									
rxn10429		TRUE		[SW] These were model specific reactions. Replaced with compounds and reactions surrounding cpd33626.					
rxn10451		TRUE		[SW] These were model specific reactions. Replaced with compounds and reactions surrounding cpd33626.					
rxn10597		TRUE		[SW] These were model specific reactions. Replaced with compounds and reactions surrounding cpd33626.					
rxn08519		TRUE		[SW] Redundant (see rxn0537) and with wrong Ferredoxin identifiers					
									
rxn07307	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=4.4.1.19-RXN				
									
rxn90051	>		-1:cpd00001:0:0:"H2O";-4:cpd00089:0:0:"Glucose-1-phosphate";-4:cpd00002:0:0:"ATP";4:cpd00012:0:0:"PPi";4:cpd00008:0:0:"ADP";1:cpd15302:0:0:"glycogen(n-1)"	[SW] dummy reaction for glycogen(n-1) biosynthesis from glucose-1-phoshate. Here n=5 is assumed.					
rxn90052	>		-2:cpd00971:0:0:"Na+";-1:cpd02246:0:0:"CoM";-1:cpd02737:0:0:"5-Methyl-H4MPT";1:cpd00895:0:0:"H4MPT";1:cpd02438:0:0:"Methyl CoM";2:cpd00971:1:0:"Na+"	[SW] sodium-pumping CH3-THSPT:HS-CoM methyltransferase (MtrA-H)	DOI: 10.1128/JB.00593-12		sodium-pumping CH3-THSPT:HS-CoM methyltransferase	sodium-pumping CH3-THSPT:HS-CoM methyltransferase	
									
rxn90053	>		-2:cpd11620:0:0:"Reducedferredoxin";-1:cpd00003:0:0:"NAD";-2:cpd00971:0:0:"Na+";-1:cpd00067:0:0:"H+";2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00004:0:0:"NADH";2:cpd00971:1:0:"Na+"	[SW] New reaction for H+ exporting Rnf electron transport complex	10.1101/2020.06.09.139246		RNF-Na-TRANSLOCATION	Na(+)-translocating ferredoxin:NAD(+) oxidoreductase complex	
rxn90054	>		-2:cpd11620:0:0:"Reducedferredoxin";-2:cpd00003:0:0:"NAD";-1:cpd00159:0:0:"L-Lactate";2:cpd11621:0:0:"Oxidizedferredoxin";2:cpd00004:0:0:"NADH";1:cpd00020:0:0:"Pyruvate"	[SW] Anaerobic oxidation of L-Lactate to Pyruvate needs a little help (by a coupled oxidation of reduced ferredoxin)	10:1111/1462-2920.12493		LDH-Etf_L	LDH-Etf complex (electron bifurcating)	
rxn90056	>		-2:cpd11620:0:0:"Reducedferredoxin";-2:cpd00003:0:0:"NAD";-1:cpd00221:0:0:"D-Lactate";2:cpd11621:0:0:"Oxidizedferredoxin";2:cpd00004:0:0:"NADH";1:cpd00020:0:0:"Pyruvate"	[SW] Anaerobic oxidation of D-Lactate to Pyruvate needs a little help (by a coupled oxidation of reduced ferredoxin)	10:1111/1462-2920.12493		LDH-Etf_D	LDH-Etf complex (electron bifurcating)	
rxn90055	>		-1:cpd00008:0:0:"ADP";-1:cpd00009:0:0:"Phosphate";-1:cpd00067:0:0:"H+";-4:cpd00971:1:0:"Na+";1:cpd00001:0:0:"H2O";1:cpd00002:0:0:"ATP";4:cpd00971:0:0:"Na+"	[SW] Na+ gradient dependen F0F1 ATPase.	10.1016/j.bbabio.2008.12.015		Na-F0F1ATPase	Na+ F1FO ATP synthase	
									
rxn10521			-1:cpd00011:0:0:"CO2";-1:cpd00067:0:0:"H+";-2:cpd11620:0:0:"Reducedferredoxin";-1:cpd15892:0:0:"methanofuran b";1:cpd00001:0:0:"H2O";2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd15879:0:0:"formylmethanofuran b"	[SW] Corrected ID of ferredoxin metabolites					
rxn10561			-1:cpd00010:0:0:"CoA";-1:cpd00278:0:0:"Indolepyruvate";-2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00011:0:0:"CO2";1:cpd11175:0:0:"S-2-(Indol-3-yl)acetyl-CoA";2:cpd11620:0:0:"Reducedferredoxin"	[SW] Corrected ID of ferredoxin metabolites					
rxn10562			-1:cpd00010:0:0:"CoA";-1:cpd00143:0:0:"Phenylpyruvate";-2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00011:0:0:"CO2";1:cpd00067:0:0:"H+";1:cpd00452:0:0:"Phenylacetyl-CoA";2:cpd11620:0:0:"Reducedferredoxin"	[SW] Corrected ID of ferredoxin metabolites					
rxn10563			-1:cpd00010:0:0:"CoA";-1:cpd00868:0:0:"p-hydroxyphenylpyruvate";-2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00011:0:0:"CO2";1:cpd03165:0:0:"4-Hydroxyphenylacetyl-CoA";2:cpd11620:0:0:"Reducedferredoxin"	[SW] Corrected ID of ferredoxin metabolites					
rxn10585			-1:cpd00010:0:0:"CoA";-1:cpd00024:0:0:"2-Oxoglutarate";-2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00011:0:0:"CO2";1:cpd00067:0:0:"H+";1:cpd00078:0:0:"Succinyl-CoA";2:cpd11620:0:0:"Reducedferredoxin"	[SW] Corrected ID of ferredoxin metabolites					
rxn10588			-1:cpd00010:0:0:"CoA";-1:cpd00020:0:0:"Pyruvate";-2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00011:0:0:"CO2";1:cpd00022:0:0:"Acetyl-CoA";1:cpd00067:0:0:"H+";2:cpd11620:0:0:"Reducedferredoxin"	[SW] Corrected ID of ferredoxin metabolites					
rxn10589			-1:cpd00010:0:0:"CoA";-1:cpd00094:0:0:"2-Oxobutyrate";-2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00011:0:0:"CO2";1:cpd00067:0:0:"H+";1:cpd00086:0:0:"Propionyl-CoA";2:cpd11620:0:0:"Reducedferredoxin"	[SW] Corrected ID of ferredoxin metabolites					
rxn10618			-1:cpd00010:0:0:"CoA";-1:cpd00123:0:0:"3-Methyl-2-oxobutanoate";-2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00011:0:0:"CO2";1:cpd00067:0:0:"H+";1:cpd00481:0:0:"Isobutyryl-CoA";2:cpd11620:0:0:"Reducedferredoxin"	[SW] Corrected ID of ferredoxin metabolites					
rxn10767	<		-1:cpd11640:0:0:"H2";-2:cpd11621:0:0:"Oxidizedferredoxin";2:cpd00067:0:0:"H+";2:cpd11620:0:0:"Reducedferredoxin"	[SW] Corrected ID of ferredoxin metabolites					
rxn10478	>		-1:cpd00001:0:0:"H2O";-1:cpd00022:0:0:"Acetyl-CoA";-2:cpd11621:0:0:"Oxidizedferredoxin";-1:cpd15884:0:0:"tetrahydrosarcinapterin";1:cpd00010:0:0:"CoA";1:cpd00011:0:0:"CO2";2:cpd00067:0:0:"H+";2:cpd11620:0:0:"Reducedferredoxin";1:cpd15893:0:0:"N5-methyl-tetrahydrosarcinapterin"	[SW] Corrected ID of ferredoxin metabolites					
rxn10580			-32:cpd00001:0:0:"H2O";-32:cpd00002:0:0:"ATP";-1:cpd00528:0:0:"N2";-8:cpd11620:0:0:"Reducedferredoxin";32:cpd00008:0:0:"ADP";32:cpd00009:0:0:"Phosphate";2:cpd00013:0:0:"NH3";22:cpd00067:0:0:"H+";1:cpd11640:0:0:"H2";8:cpd11621:0:0:"Oxidizedferredoxin"	[SW] Corrected ID of ferredoxin metabolites					
rxn10477			-1:cpd00001:0:0:"H2O";-1:cpd00204:0:0:"CO";-2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00011:0:0:"CO2";3:cpd00067:0:0:"H+";2:cpd11620:0:0:"Reducedferredoxin"	[SW] Corrected ID of ferredoxin metabolites					
rxn10572	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-5247				
rxn10574	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-5247				
									
									
rxn00202	=			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=HOMOCITRATE-SYNTHASE-RXN				
rxn10610	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=R214-RXN				
rxn10611	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=R218-RXN				
rxn10475	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=R227-RXN				
rxn03126	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.8.98.1-RXN				
rxn24614	>		-1:cpd08701:0:0:"Methanophenazine";-1:cpd00792:0:0:"Reduced coenzyme F420-2";1:cpd08702:0:0:"Dihydromethanophenazine";1:cpd00649:0:0:"Coenzyme F420-2"	[SW] direction changed according to MetaCyc and replaced F420 factors with earlier IDs	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-8106				
rxn06299	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=COENZYME-F420-HYDROGENASE-RXN				
rxn10566	>		-1:cpd15839:0:0:"7,8-didemethyl-8-hydroxy-5-deazariboflavin";-1:cpd15889:0:0:"lactyl-(2)-diphospho-(5')-guanosine";1:cpd00067:0:0:"H+";1:cpd00126:0:0:"GMP";1:cpd20413:0:0:"Coenzyme F420-0"	[SW] direction changed according to MetaCyc and replaced F420 factors IDs	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-21089				
rxn10525	>		-1:cpd00023:0:0:"L-Glutamate";-1:cpd00038:0:0:"GTP";-1:cpd20413:0:0:"Coenzyme F420-0";1:cpd00009:0:0:"Phosphate";1:cpd00031:0:0:"GDP";1:cpd00067:0:0:"H+";1:cpd20412:0:0:"Coenzyme F420-1"	[SW] direction changed according to MetaCyc and replaced F420 factors IDs	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-8080				
rxn10526	>		-1:cpd00023:0:0:"L-Glutamate";-1:cpd00038:0:0:"GTP";-1:cpd20412:0:0:cpd20412:0:0:"Coenzyme F420-1";1:cpd00009:0:0:"Phosphate";1:cpd00031:0:0:"GDP";1:cpd00067:0:0:"H+";1:cpd00649:0:0:"Coenzyme F420-2"	[SW] direction changed according to MetaCyc and replaced F420 factors IDs	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-8081				
									
rxn10464			-1:cpd00001:0:0:"H2O";-1:cpd15862:0:0:"coenzyme F390 (adenosine)";1:cpd00018:0:0:"AMP";1:cpd00067:0:0:"H+";1:cpd00649:0:0:"Coenzyme F420-2"	[SW] replace F420 factor ID					
rxn10465			-1:cpd00001:0:0:"H2O";-1:cpd15863:0:0:"coenzyme F390 (guanosine)";1:cpd00067:0:0:"H+";1:cpd00126:0:0:"GMP";1:cpd00649:0:0:"Coenzyme F420-2"	[SW] replace F420 factor ID					
rxn10466	>		-1:cpd00002:0:0:"ATP";-1:cpd00649:0:0:"Coenzyme F420-2";1:cpd00012:0:0:"PPi";1:cpd00067:0:0:"H+";1:cpd15862:0:0:"coenzyme F390 (adenosine)"	[SW] replace F420 factor ID					
rxn10467	>		-1:cpd00038:0:0:"GTP";-1:cpd00649:0:0:"Coenzyme F420-2";1:cpd00012:0:0:"PPi";1:cpd00067:0:0:"H+";1:cpd15863:0:0:"coenzyme F390 (guanosine)"	[SW] replace F420 factor ID					
									
rxn10513			-1.8:cpd00067:0:0:"H+";-1:cpd00792:0:0:"Reduced coenzyme F420-2";-1:cpd15897:0:0:"methanophenazine (oxidized)";1.8:cpd00067:1:0:"H+";1:cpd00649:0:0:"Coenzyme F420-2";1:cpd15898:0:0:"methanophenazine (reduced)"	[SW] replace F420 factor ID					
rxn10514			-1:cpd00007:0:0:"O2";-2:cpd00792:0:0:"Reduced coenzyme F420-2";2:cpd00001:0:0:"H2O";2:cpd00649:0:0:"Coenzyme F420-2"	[SW] replace F420 factor ID					
rxn10515			-1:cpd00792:0:0:"Reduced coenzyme F420-2";-1:cpd15891:0:0:"methenyl-tetrahydrosarcinapterin";1:cpd00067:0:0:"H+";1:cpd00649:0:0:"Coenzyme F420-2";1:cpd15894:0:0:"N5,N10-methylene-5,6,7,8-tetrahydromethanopterin"	[SW] replace F420 factor ID					
rxn10516			-1:cpd00792:0:0:"Reduced coenzyme F420-2";-1:cpd15894:0:0:"N5,N10-methylene-5,6,7,8-tetrahydromethanopterin";1:cpd00649:0:0:"Coenzyme F420-2";1:cpd15893:0:0:"N5-methyl-tetrahydrosarcinapterin"	[SW] replace F420 factor ID					
rxn10518			-1:cpd00005:0:0:"NADPH";-1:cpd00067:0:0:"H+";-1:cpd00649:0:0:"Coenzyme F420-2";1:cpd00006:0:0:"NADP";1:cpd00792:0:0:"Reduced coenzyme F420-2"	[SW] replace F420 factor ID					
rxn10519			-1:cpd11640:0:0:"H2";-1:cpd00649:0:0:"Coenzyme F420-2";1:cpd00792:0:0:"Reduced coenzyme F420-2"	[SW] replace F420 factor ID					
rxn10524			-1:cpd00079:0:0:"D-glucose-6-phosphate";-1:cpd00649:0:0:"Coenzyme F420-2";1:cpd00911:0:0:"6-phospho-D-glucono-1-5-lactone";1:cpd00792:0:0:"Reduced coenzyme F420-2"	[SW] replace F420 factor ID					
rxn10527	>		-1:cpd00023:0:0:"L-Glutamate";-1:cpd00038:0:0:"GTP";-1:cpd00649:0:0:"Coenzyme F420-2";1:cpd00009:0:0:"Phosphate";1:cpd00031:0:0:"GDP";1:cpd00067:0:0:"H+";1:cpd20411:0:0:"Coenzyme F420-3"	[SW] replace F420 factor ID					
rxn10535			-1:cpd00024:0:0:"2-Oxoglutarate";-1:cpd00053:0:0:"L-Glutamine";-1:cpd00792:0:0:"Reduced coenzyme F420-2";2:cpd00023:0:0:"L-Glutamate";1:cpd00649:0:0:"Coenzyme F420-2"	[SW] replace F420 factor ID					
rxn10540			-1:cpd03523:0:0:"7,8-Dihydromethanopterin";-1:cpd00792:0:0:"Reduced coenzyme F420-2";1:cpd00895:0:0:"H4MPT";1:cpd00649:0:0:"Coenzyme F420-2"	[SW] replace F420 factor ID					
rxn10552			-1:cpd15851:0:0:"7,8-dihydropterin-6-ylmethyl-4-(B-D-ribofuranosyl) aminobenzene 5'-phosphate";-1:cpd00792:0:0:"Reduced coenzyme F420-2";1:cpd15847:0:0:"7,8-dihydropterin-6-ylmethyl-1-(4-aminophenyl)-1-deoxy-D-ribitol 5'-phosphate";1:cpd00649:0:0:"Coenzyme F420-2"	[SW] replace F420 factor ID					
rxn10564			-1:cpd00004:0:0:"NADH";-1:cpd00067:0:0:"H+";-1:cpd00113:0:0:"Isopentenyldiphosphate";-1:cpd00649:0:0:"Coenzyme F420-2";1:cpd00003:0:0:"NAD";1:cpd00202:0:0:"DMAPP";1:cpd00792:0:0:"Reduced coenzyme F420-2"	[SW] replace F420 factor ID					
rxn10565			-1:cpd00005:0:0:"NADPH";-1:cpd00067:0:0:"H+";-1:cpd00113:0:0:"Isopentenyldiphosphate";-1:cpd00649:0:0:"Coenzyme F420-2";1:cpd00006:0:0:"NADP";1:cpd00202:0:0:"DMAPP";1:cpd00792:0:0:"Reduced coenzyme F420-2"	[SW] replace F420 factor ID					
									
rxn10489			-1:cpd00282:0:0:"S-Dihydroorotate";-1:cpd00649:0:0:"Coenzyme F420-2";1:cpd00247:0:0:"Orotate";1:cpd00792:0:0:"Reduced coenzyme F420-2"	[SW] replace F420 factor ID					
									
rxn10528	>		-1:cpd00023:0:0:"L-Glutamate";-1:cpd00038:0:0:"GTP";-1:cpd20411:0:0:"Coenzyme F420-3";1:cpd00009:0:0:"Phosphate";1:cpd00031:0:0:"GDP";1:cpd00067:0:0:"H+";1:cpd15869:0:0:"coenzyme ferredoxin 420-4"	[SW] direction changed according to MetaCyc					
rxn10529	>			[SW] direction changed according to MetaCyc					
rxn10530	>			[SW] direction changed according to MetaCyc					
rxn10531	>			[SW] direction changed according to MetaCyc					
rxn06294	<		-1:cpd00001:0:0:"H2O";-1:cpd00735:0:0:"Formylmethanofuran";-2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00011:0:0:"CO2";1:cpd00643:0:0:"Methanofuran";2:cpd11620:0:0:"Reducedferredoxin";1:cpd00067:0:0:"H+"	[SW] Direction and stoichiometry changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=FORMYLMETHANOFURAN-DEHYDROGENASE-RXN				
rxn15964	>			[SW] Unknown directionality but causes futile cycles in reverse direction.					
rxn15963	>			[SW] Unknown directionality but causes futile cycles in reverse direction. Delta_r G indicated irreversibility ast physiological conditions.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=MTAMBARKMULTI-RXN				
rxn10568	>			[SW] Unknown directionality but causes futile cycles in reverse direction. Delta_r G indicated irreversibility ast physiological conditions.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=MTAMBARKMULTI-RXN				
rxn10613	>			[SW] Unknown directionality but causes futile cycles in reverse direction.					
rxn15988	>			[SW] Unknown directionality but causes futile cycles in reverse direction.					
rxn10496	>			[SW] Unknown directionality but causes futile cycles in reverse direction.					
rxn03020	>			[SW] Unknown directionality but causes futile cycles in reverse direction. Delta_r G indicated irreversibility ast physiological conditions.	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=MTRMBARK-RXN				
rxn16150	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-8957				
rxn00972	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CITLY-RXN				
rxn14226	<			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=2-HEXADECENAL-REDUCTASE-RXN				
rxn02229		TRUE		[SW] not found in any reaction database					
rxn01416	>			[SW] direction changed according to MetaCyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=THIOSULFATE-SULFURTRANSFERASE-RXN				
rxn10457	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=CDPDIGLYSYN-RXN				
rxn10503	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-6350&detail-level=2				
rxn10532	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-6350&detail-level=2				
rxn10456	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-6350&detail-level=2				
rxn10430	>			[SW] direction changed according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-6350&detail-level=2				
									
rxn90057	=		-4:cpd00067:0:0:"H+";-2:cpd11620:0:0:"Reducedferredoxin";2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd11640:0:0:"H2";2:cpd00067:1:0:"H+"	[JZ] rxn05759 can be reversible when linked to membrane potential	http://dx.doi.org/10.1038/nrmicro1931		ECHAF	ferredoxin hydrogenase (chemiosmosis)	
rxn90058	=		-3:cpd00067:0:0:"H+";-1:cpd02935:0:0:"CoM-S-S-CoB";-1:cpd08702:0:0:"Dihydromethanophenazine";1:cpd02246:0:0:"CoM";1:cpd02817:0:0:"HTP";1:cpd08701:0:0:"Methanophenazine";2:cpd00067:1:0:"H+"	[JZ] rxn03126 can be reversible when linked to membrane potential	http://dx.doi.org/10.1038/nrmicro1931			Coenzyme B:coenzyme M:methanophenazine oxidoreductase (chemiosmosis)	
rxn90059	<		-2:cpd00067:0:0:"H+";-1:cpd08701:0:0:"Methanophenazine";-1:cpd11640:0:0:"H2";1:cpd08702:0:0:"Dihydromethanophenazine";2:cpd00067:1:0:"H+"	[JZ] rxn16961 can be reversible when linked to membrane potential	http://dx.doi.org/10.1038/nrmicro1931			hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase  (chemiosmosis)	
rxn15961	>			[JZ] direction changed according to MetaCyc + Thauer2008	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-7733 http://dx.doi.org/10.1038/nrmicro1931				
rxn90060	>		-1:cpd28763:1:0:"Inulin";-9:cpd00001:1:0:"H2O";9:cpd00082:1:0:"D-Fructose";1:cpd02298:1:0:"1F-beta-D-Fructosylsucrose"	[SW] New reaction for inulin/fructan degradation step 1	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.2.1.153-RXN		inulinase	fructan beta-(2,1)-fructosidase (extracellular)	
rxn23749	>		-1:cpd00001:0:0:"H2O";-1:cpd02298:0:0:"1F-beta-D-Fructosylsucrose";1:cpd00076:0:0:"Sucrose";1:cpd00082:0:0:"D-Fructose"	[SW] Reaction needed for 1-Kestotriose degradation	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-1841				
rxn29739				[SW] Needed for 1-Kestotriose uptake					TRUE
rxn23769	>		-3:cpd00001:0:0:"H2O";-1:cpd27519:0:0:"Methylesterified-homogalacturonan";3:cpd00116:0:0:"Methanol";1:cpd21755:0:0:"1-4-alpha-D-galacturonosyl";3:cpd00067:0:0:"H+"	[SW] Reaction for first step pectin degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7248				
rxn90062	>		-1:cpd21755:0:0:"1-4-alpha-D-galacturonosyl";-2:cpd00001:0:0:"H2O";3:cpd00280:0:0:"D-Galacturonate"	[SW] Reaction for pectin degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7248		exopolygalacturonase	galacturonan 1,4-alpha-galacturonidase	
rxn90063	=		-1:cpd00437:0:0:"D-Tagaturonate";1:cpd00672:0:0:"D-Fructuronate"	[SW] Reaction for pectin degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7248		tagaturonate epimerase	tagaturonate epimerase	
rxn90064	>		-1:cpd00001:0:0:"H2O";-1:cpd00002:0:0:"ATP";-1:cpd21755:1:0:"1-4-alpha-D-galacturonosyl";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate";1:cpd21755:0:0:"1-4-alpha-D-galacturonosyl";1:cpd00067:0:0:"H+"	[SW] Reaction for Pectin component import (ABC)			homogalacturonate ABC transporter	homogalacturonate ABC transporter	
rxn90065	>		-1:cpd00001:0:0:"H2O";-1:cpd00002:0:0:"ATP";-1:cpd27519:1:0:"Methylesterified-homogalacturonan";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate";1:cpd27519:0:0:"Methylesterified-homogalacturonan";1:cpd00067:0:0:"H+"	[SW] Reaction for Pectin component import (ABC)			Methylestherified-homogalacturonate ABC transporter	Methylestherified-homogalacturonate ABC transporter	
rxn90066	>		-1:cpd21755:0:0:"1-4-alpha-D-galacturonosyl";-1:cpd00001:0:0:"H2O";1:cpd01532:0:0:"Digalacturonate";1:cpd00280:0:0:"D-Galacturonate"	[SW] Reaction for pectin degradation	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=3.2.1.82-RXN		Exo-poly-alpha-galacturonosidase 	Exo-poly-alpha-galacturonosidase 	
rxn21843									TRUE
rxn90067	>		-1:cpd02387:0:0:"2-Dehydro-3-deoxy-L-fuconate";1:cpd00334:0:0:"L-Lactaldehyde";1:cpd00020:0:0:"Pyruvate"	[SW] Reaction for recently described L-2-Keto-3-deoxyfuconate aldolase	10.1074/jbc.RA119.011854		L-KDF-aldolase	L-2-keto-3-deoxyfuconate aldolase	
									
rxn13667			-8:cpd00005:0:0:"NADPH";-12:cpd00067:0:0:"H+";-4:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd17015:0:0:"Iso-C6:0 ACP";4:cpd00001:0:0:"H2O";8:cpd00006:0:0:"NADP";4:cpd00011:0:0:"CO2";4:cpd11493:0:0:"ACP";1:cpd17011:0:0:"Iso-C14:0 ACP"	[SW] Mass and charge balanced					
rxn13668			-8:cpd00005:0:0:"NADPH";-12:cpd00067:0:0:"H+";-4:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd17014:0:0:"Iso-C7:0 ACP";4:cpd00001:0:0:"H2O";8:cpd00006:0:0:"NADP";4:cpd00011:0:0:"CO2";4:cpd11493:0:0:"ACP";1:cpd17012:0:0:"iso-C15:0 ACP"	[SW] Mass and charge balanced					
rxn13669			-10:cpd00005:0:0:"NADPH";-15:cpd00067:0:0:"H+";-5:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd17010:0:0:"Fatty Acid (n-C5:0 ACP)";5:cpd00001:0:0:"H2O";10:cpd00006:0:0:"NADP";5:cpd00011:0:0:"CO2";5:cpd11493:0:0:"ACP";1:cpd17029:0:0:"pentadecanoyl-ACP (n-C15:0ACP)"	[SW] Mass and charge balanced					
rxn13671			-10:cpd00005:0:0:"NADPH";-15:cpd00067:0:0:"H+";-5:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd17015:0:0:"Iso-C6:0 ACP";5:cpd00001:0:0:"H2O";10:cpd00006:0:0:"NADP";5:cpd00011:0:0:"CO2";5:cpd11493:0:0:"ACP";1:cpd17013:0:0:"Iso-C16:0 ACP"	[SW] Mass and charge balanced					
rxn13673			-12:cpd00005:0:0:"NADPH";-18:cpd00067:0:0:"H+";-6:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd17010:0:0:"Fatty Acid (n-C5:0 ACP)";6:cpd00001:0:0:"H2O";12:cpd00006:0:0:"NADP";6:cpd00011:0:0:"CO2";6:cpd11493:0:0:"ACP";1:cpd17018:0:0:"heptadecanoyl-ACP (n-C17:0ACP)"	[SW] Mass and charge balanced					
rxn11114		TRUE		[SW] redundant to rxn06434					
rxn11711			-1:cpd00001:0:0:"H2O";-1:cpd00399:0:0:"Oleoyl-CoA";1:cpd00010:0:0:"CoA";1:cpd00067:0:0:"H+";1:cpd00536:0:0:"Oleate"	[SW] Mass and charge balanced					
									
rxn14216			-1:cpd00017:0:0:"S-Adenosyl-L-methionine";-1:cpd13372:0:0:"tRNA containing 5-aminomethyl-2-thiouridine";1:cpd00019:0:0:"S-Adenosyl-homocysteine";1:cpd12598:0:0:"tRNA containing 5-methylaminomethyl-2-thiouridylate";1:cpd00067:0:0:"H+"	[SW] Mass and charge balanced	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN0-5144				
rxn15526		TRUE		[SW] wrong reaction stoichiometry. Correct version of reaction ist rxn06875 .					
									
rxn02015	>		-1:cpd00001:1:0:"H2O";-1:cpd03047:1:0:"Taurocholate";1:cpd00210:1:0:"Taurine";1:cpd00526:1:0:"Cholate"	[JZ] wrong direction + extracellular	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-17385				
rxn04068	>		-1:cpd00001:1:0:"H2O";-1:cpd01318:1:0:"Glycocholate";1:cpd00033:1:0:"Glycine";1:cpd00526:1:0:"Cholate"	[JZ] only forward direction + extracellular	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CHOLOYLGLYCINE-HYDROLASE-RXN				
rxn02796	>		-1:cpd00001:1:0:"H2O";-1:cpd03246:1:0:"Taurochenodeoxycholate";1:cpd00210:1:0:"Taurine";1:cpd01663:1:0:"Chenodiol"	[JZ] only forward direction + extracellular	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN				
rxn02795	>		-1:cpd00001:1:0:"H2O";-1:cpd03247:1:0:"Glycochenodeoxycholate";1:cpd00033:1:0:"Glycine";1:cpd01663:1:0:"Chenodiol"	[JZ] only forward direction + extracellular	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-17388				
rxn02012	>			[JZ] only forward direction	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=7-ALPHA-HYDROXYSTEROID-DEH-RXN				
rxn90068	>		-1:cpd00003:0:0:"NAD";-1:cpd00526:1:0:"Cholate";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd02829:1:0:"3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate"	[JZ] identical to rxn02012 but external redox-pair	https://www.vmh.life/#reaction/7AHSDHe		7AHSDHe	7-alpha hydroxysteroid dehydrogenase, NAD+ dependent, cholate specific	
rxn21853			-1:cpd00005:0:0:"NADPH";-1:cpd00067:0:0:"H+";-1:cpd02829:0:0:"3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate";1:cpd00006:0:0:"NADP";1:cpd17760:0:0:"Ursocholate"	[JZ] updated stoichiometry (one proton less)	https://modelseed.org/biochem/reactions/rxn21853				
rxn90069	=		-1:cpd00004:0:0:"NADH";-1:cpd00067:0:0:"H+";-1:cpd02829:1:0:"3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate";1:cpd00003:0:0:"NAD";1:cpd17760:1:0:"Ursocholate"	[JZ] identical to rxn21853 but extracellular redox-pair and with NADH instead of NADPH	https://www.vmh.life/#reaction/UCA7bHSDHe		UCA7bHSDHe	7-beta hydroxysteroid dehydrogenase, NAD+ dependent, ursocholate specific	
rxn90073	=		-1:cpd00003:0:0:"NAD";-1:cpd00526:1:0:"Cholate";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd00949:1:0:"3alpha,7alpha-Dihydroxy-12-oxo-5beta-cholanate"	[JZ] identical to rxn02013 but external redox-pair and with NADH instead of NADPH	https://www.vmh.life/#reaction/12aHSDHe		12aHSDHe	12-alpha hydroxysteroid dehydrogenase, NAD+ dependent	
rxn90074	=		-1:cpd00003:0:0:"NAD";-1:cpd02840:1:0:"3alpha,7alpha,12beta-Trihydroxy-5beta-cholanate";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd00949:1:0:"3alpha,7alpha-Dihydroxy-12-oxo-5beta-cholanate"	[JZ] identical to rxn02498 but external redox-pair and with NADH instead of NADPH				12beta-hydroxysteroid:NADP+ 12-oxidoreductase	
rxn21854									TRUE
rxn21855									TRUE
rxn90075	=		-1:cpd00003:0:0:"NAD";-1:cpd00526:1:0:"Cholate";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd23431:1:0:"3-dehydrocholate"	[JZ] identical to rxn21854 but external redox-pair	https://www.vmh.life/#reaction/CA3aHSDHe		CA3aHSDHe	3-alpha hydroxysteroid dehydrogenase, NAD+ dependent	
rxn90076	=		-1:cpd00004:0:0:"NADH";-1:cpd00067:0:0:"H+";-1:cpd23431:1:0:"3-dehydrocholate";1:cpd00003:0:0:"NAD";1:cpd23430:1:0:"isocholate"	[JZ] identical to rxn21855 but external redox-pair	https://www.vmh.life/#reaction/ICA3bHSDHe		ICA3bHSDHe	3-beta hydroxysteroid dehydrogenase, NAD+ dependent	
rxn42818	>		-1:cpd00003:0:0:"NAD";-1:cpd01663:0:0:"Chenodiol";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd35610:0:0:"3alpha-hydroxy-7-oxo-5beta-cholan-24-oate"	[JZ] Added from new seed reactions + forward direction only	https://modelseed.org/biochem/reactions/rxn42818 https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-16033		chenodeoxycholate dehydrogenase chenodeoxycholate dehydrogenase	chenodeoxycholate dehydrogenase chenodeoxycholate dehydrogenase	
rxn45750	<		-1:cpd00006:0:0:"NADP";-1:cpd04945:0:0:"Ursodiol";1:cpd00005:0:0:"NADPH";1:cpd00067:0:0:"H+";1:cpd35610:0:0:"3alpha-hydroxy-7-oxo-5beta-cholan-24-oate"	[JZ] Added from new seed reactions + backward direction only	https://modelseed.org/biochem/reactions/rxn45750 https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-16034		7-hydroxysteroid dehydrogenase	7-hydroxysteroid dehydrogenase	
rxn90077	>		-1:cpd00003:0:0:"NAD";-1:cpd01663:1:0:"Chenodiol";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd35610:1:0:"3alpha-hydroxy-7-oxo-5beta-cholan-24-oate"	[JZ] identical to rxn42818 but external redox-pair	https://www.vmh.life/#reaction/CDCA7aHSDHe		CDCA7aHSDHe	7-alpha hydroxysteroid dehydrogenase, NAD+ dependent	
rxn90078	<		-1:cpd00003:0:0:"NAD";-1:cpd04945:1:0:"Ursodiol";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd35610:1:0:"3alpha-hydroxy-7-oxo-5beta-cholan-24-oate"	[JZ] identical to rxn45750 but external redox-pair and with NADH instead of NADPH	https://www.vmh.life/#reaction/UDCA7bHSDHe		UDCA7bHSDHe	7-beta hydroxysteroid dehydrogenase, NAD+ dependent	
rxn19220	>			[JZ] wrong direction	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=BAI3OXO-OXRED-RXN				
rxn90079	>		-1:cpd00067:0:0:"H+";-1:cpd22042:0:0:"3-oxo-delta4,6-cholyl-CoA, 4";-1:cpd00526:0:0:"Cholate";1:cpd11235:0:0:"12alpha-Hydroxy-3-oxochola-4,6-dienoate, 4";1:cpd01237:0:0:"Choloyl-CoA"	[JZ] new reaction for BaiF needed for 7-alpha-dehydroxylation pathways (new pathway was described only in 2020 => BaiE and BaiF reactions are mixed in metacyc)	https://doi.org/10.1038/s41586-020-2396-4		BaiF	bile acid CoA-transferase	
rxn36658									TRUE
rxn46416	=		-1:cpd00003:0:0:"NAD";-1:cpd03164:0:0:"Chenodeoxycholoyl-CoA";1:cpd00004:0:0:"NADH";2:cpd00067:0:0:"H+";1:cpd32588:0:0:"3-oxochenodeoxycholoyl-CoA"	[JZ] Added from new seed reactions	https://modelseed.org/biochem/reactions/rxn46416		3-hydroxy bile acid-CoA-ester 3-dehydrogenase	3-hydroxy bile acid-CoA-ester 3-dehydrogenase	
rxn41945	=		-1:cpd00003:0:0:"NAD";-1:cpd32588:0:0:"3-oxochenodeoxycholoyl-CoA";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd32967:0:0:"7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA"	[JZ] Added from new seed reactions	https://modelseed.org/biochem/reactions/rxn41945		3-oxocholoyl-CoA 4-desaturase	3-oxocholoyl-CoA 4-desaturase	
rxn43831	=		-1:cpd32967:0:0:"7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA";1:cpd00001:0:0:"H2O";1:cpd34820:0:0:"3-oxo-delta4,6-7-deoxy-chenodeoxycholoyl-CoA"	[JZ] Added from new seed reactions	https://modelseed.org/biochem/reactions/rxn43831				
rxn41554	<		-1:cpd00003:0:0:"NAD";-1:cpd32012:0:0:"12-alpha-hydroxy-3 oxochol-4-enoate";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd11235:0:0:"12alpha-Hydroxy-3-oxochola-4,6-dienoate"	[JZ] Added from new seed reactions	https://modelseed.org/biochem/reactions/rxn41554		BaiH	3-dehydro-bile acid Δ4,6-reductase	
rxn43871	<		-1:cpd00003:0:0:"NAD";-1:cpd35799:0:0:"12alpha-hydroxy-3-oxo-5beta-cholan-24-oate";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd32012:0:0:"12-alpha-hydroxy-3 oxochol-4-enoate"	[JZ] Added from new seed reactions	https://modelseed.org/biochem/reactions/rxn43871				
rxn45097	=		-1:cpd00003:0:0:"NAD";-1:cpd02733:0:0:"Deoxycholate";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd35799:0:0:"12alpha-hydroxy-3-oxo-5beta-cholan-24-oate"	[JZ] Added from new seed reactions	https://modelseed.org/biochem/reactions/rxn45097		3alpha-HSDH-DCA-NADH	3alpha-hydroxycholanate dehydrogenase (NAD+) utilizing DCA	
rxn90080	>		-1:cpd00067:0:0:"H+";-1:cpd34820:0:0:"3-oxo-delta4,6-7-deoxy-chenodeoxycholoyl-CoA";-1:cpd01663:0:0:"Chenodeoxycholate";1:cpd90013:0:0:"3-oxochol-4,6-dienoate";1:cpd03164:0:0:"Chenodeoxycholoyl-CoA"	[JZ] new reaction for BaiF needed for 7-alpha-dehydroxylation pathways (new pathway was described only in 2020 => BaiE and BaiF reactions are mixed in metacyc)	https://doi.org/10.1038/s41586-020-2396-4		BaiF	bile acid CoA-transferase	
rxn90081	<		-1:cpd00003:0:0:"NAD";-1:cpd90014:0:0:"3-oxochol-4-en-24-oate";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd90013:0:0:"3-oxochol-4,6-dienoate"	[JZ] Added from metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-21340		BaiH	3-dehydro-bile acid Δ4,6-reductase	
rxn90082	<		-1:cpd00003:0:0:"NAD";-1:cpd01967:0:0:"3-Oxo-5beta-cholanate";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd90014:0:0:"3-oxochol-4-en-24-oate"	[JZ] Added from metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-21341		BaiCD	3-dehydro-bile acid Δ4,6-reductase	
rxn90083	=		-1:cpd02475:0:0:"Lithocholate";-1:cpd00067:0:0:"H+";1:cpd02475:1:0:"Lithocholate";1:cpd00067:1:0:"H+"	[JZ] Added from vmh	https://www.vmh.life/#reaction/LCAT			Lithocholate transporter	
rxn43262	=		-1:cpd02733:0:0:"Deoxycholate";-1:cpd00067:0:0:"H+";1:cpd02733:1:0:"Deoxycholate";1:cpd00067:1:0:"H+"	[JZ] Added from new seed reactions + corrected protonation (symport as in vmh)	https://modelseed.org/biochem/reactions/rxn43262			Deoxycholate transporter	
rxn47305	=		-1:cpd00526:0:0:"Cholate";-1:cpd00067:0:0:"H+";1:cpd00526:1:0:"Cholate";1:cpd00067:1:0:"H+"	[JZ] Added from new seed reactions + corrected protonation (symport as in vmh)	https://modelseed.org/biochem/reactions/rxn47305			Cholate transporter	
rxn40935	=		-1:cpd01663:0:0:"Chenodeoxycholate";-1:cpd00067:0:0:"H+";1:cpd01663:1:0:"Chenodeoxycholate";1:cpd00067:1:0:"H+"	[JZ] Added from new seed reactions + corrected protonation (symport as in vmh)	https://modelseed.org/biochem/reactions/rxn40935			Chenodeoxycholate transporter	
									
rxn06186		TRUE		[SW] incomplete reaction					
rxn06530		TRUE		[SW] incomplete reaction					
rxn06552		TRUE		[SW] incomplete reaction					
rxn07276		TRUE		[SW] incomplete reaction					
rxn10980		TRUE		[SW] model specific reaction					
rxn11005		TRUE		[SW] model specific reaction					
rxn10907		TRUE		[SW] model specific reaction					
rxn10926		TRUE		[SW] model specific reaction					
rxn10925		TRUE		[SW] model specific reaction					
rxn11002		TRUE		[SW] model specific reaction					
rxn10949		TRUE		[SW] model specific reaction					
rxn10989		TRUE		[SW] model specific reaction					
rxn11015		TRUE		[SW] model specific reaction					
rxn06330		TRUE		[SW] generic reaction.					
rxn11352		TRUE		[SW] model specific reaction					
rxn11353		TRUE		[SW] model specific reaction					
									
rxn06071			-1:cpd00067:0:0:"H+";-1:cpd00003:0:0:"NAD";-2:cpd11651:0:0:"Reduced rubredoxin";1:cpd00004:0:0:"NADH";2:cpd11681:0:0:"Oxidized rubredoxin"	[SW] Corrected according to MetaCyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RUBREDOXIN--NAD%2b-REDUCTASE-RXN				
rxn06072			-1:cpd00067:0:0:"H+";-1:cpd00006:0:0:"NADP";-2:cpd11651:0:0:"Reduced rubredoxin";1:cpd00005:0:0:"NADPH";2:cpd11681:0:0:"Oxidized rubredoxin"	[SW] Corrected according to MetaCyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RUBREDOXIN--NADP%2b-REDUCTASE-RXN				
rxn06268			-2:cpd00067:0:0:"H+";-1:cpd00007:0:0:"O2";-1:cpd00998:0:0:"Octane";-2:cpd11651:0:0:"Reduced rubredoxin";1:cpd00001:0:0:"H2O";1:cpd00562:0:0:"1-Octanol";2:cpd11681:0:0:"Oxidized rubredoxin"	[SW] Corrected according to MetaCyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=ALKANE-1-MONOOXYGENASE-RXN				
rxn06589			-2:cpd00067:0:0:"H+";-1:cpd00007:0:0:"O2";-1:cpd01943:0:0:"2,5-Diketocamphane";-2:cpd11651:0:0:"Reduced rubredoxin";1:cpd00001:0:0:"H2O";1:cpd01894:0:0:"5-Oxo-1,2-campholide";2:cpd11681:0:0:"Oxidized rubredoxin"	[SW] Corrected according to MetaCyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=ALKANE-1-MONOOXYGENASE-RXN				
rxn06922			-2:cpd00067:0:0:"H+";-1:cpd00007:0:0:"O2";-1:cpd04450:0:0:"o-Xylene";-2:cpd11651:0:0:"Reduced rubredoxin";1:cpd00001:0:0:"H2O";1:cpd04451:0:0:"2-Methylbenzyl alcohol";2:cpd11681:0:0:"Oxidized rubredoxin"	[SW] Corrected according to MetaCyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=ALKANE-1-MONOOXYGENASE-RXN				
rxn06923			-2:cpd00067:0:0:"H+";-1:cpd00007:0:0:"O2";-1:cpd04136:0:0:"p-Xylene";-2:cpd11651:0:0:"Reduced rubredoxin";1:cpd00001:0:0:"H2O";1:cpd04137:0:0:"4-Tolylcarbinol";2:cpd11681:0:0:"Oxidized rubredoxin"	[SW] Corrected according to MetaCyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=ALKANE-1-MONOOXYGENASE-RXN				
rxn06924			-2:cpd00067:0:0:"H+";-1:cpd00007:0:0:"O2";-1:cpd04446:0:0:"m-Xylene";-2:cpd11651:0:0:"Reduced rubredoxin";1:cpd00001:0:0:"H2O";1:cpd04454:0:0:"3-methylbenzylalcohol";2:cpd11681:0:0:"Oxidized rubredoxin"	[SW] Corrected according to MetaCyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=ALKANE-1-MONOOXYGENASE-RXN				
									
rxn12922			-1:cpd00067:0:0:"H+";-1:cpd00005:0:0:"NADPH";-1:cpd14940:0:0:"(2E)-Octadecenoyl-[acp]";1:cpd00006:0:0:"NADP";1:cpd12458:0:0:"Stearoyl-[acyl-carrier protein]"	[SW] substitute cpd16828 with cpd12458. Plus proton balancing					
rxn12936			-1:cpd00010:0:0:"CoA";-1:cpd12458:0:0:"Stearoyl-[acyl-carrier protein]";1:cpd11493:0:0:"ACP";1:cpd16825:0:0:"octadecanoyl-CoA"	[SW] substitute cpd16828 with cpd12458					
rxn13158			-1:cpd12458:1:0:"Stearoyl-[acyl-carrier protein]";1:cpd12458:0:0:"Stearoyl-[acyl-carrier protein]"	[SW] substitute cpd16828 with cpd12458					
									
rxn10872		TRUE		[SW] model specific reaction					
rxn10882		TRUE		[SW] model specific reaction					
rxn10408		TRUE		[SW] duplicate reaction to rxn05251 but with wrong cpd-id for fatty acid product					
									
rxn90070	<		-1:cpd00047:0:0:"Formate";-2:cpd11621:0:0:"Oxidizedferredoxin";1:cpd00011:0:0:"CO2";1:cpd00067:0:0:"H+";2:cpd11620:0:0:"Reducedferredoxin"	[SW] ferredoxin based formate dehydrogenase for CO2 assimilation; possible entry to Ljungdahl-Wood pathway	https://doi.org/10.1186/1475-2859-12-118 https://doi.org/10.3389/fbioe.2020.621166		FDH-frdx	formate dehydrogenase (ferredoxin)	
rxn01211	=			[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=METHENYLTHFCYCLOHYDRO-RXN&&detail-level=2				
rxn06149	=		-1:cpd00067:0:0:"H+";-1:cpd00345:0:0:"5-Methyltetrahydrofolate";-1:cpd12810:0:0:"Corrinoid";1:cpd00087:0:0:"Tetrahydrofolate";1:cpd12809:0:0:"Methylcorrinoid"	[SW] balanced and corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=METHCOCLTH-RXN&&detail-level=2				
rxn12080	=		-2:cpd00067:0:0:"H+";-1:cpd00022:0:0:"Acetyl-CoA";-1:cpd12810:0:0:"Corrinoid";1:cpd00010:0:0:"CoA";1:cpd00204:0:0:"CO";1:cpd12809:0:0:"Methylcorrinoid"	[SW] balanced and corrected according to MetaCyc; EC 2.3.1.169	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=ACETYLSYNCLTH-RXN&&detail-level=2				
rxn15370	>			[SW] Corrected according to BRENDA	https://www.brenda-enzymes.org/enzyme.php?ecno=4.4.1.9#NATURAL%20SUBSTRATE				
rxn09412		TRUE		[SW] never reported with NAD as electron carrier, but with NADP (rxn02373)	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLUTSEMIALDEHYDROG-RXN				
rxn13071		TRUE		[SW] never reported with NAD as electron carrier, but with NADP (rxn02373)	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLUTSEMIALDEHYDROG-RXN				
rxn13072	>			[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLUTSEMIALDEHYDROG-RXN				
									
rxn90071	=		-2:cpd11620:0:0:"Reducedferredoxin";-2:cpd00003:0:0:"NAD";-1:cpd00345:0:0:"5-Methyltetrahydrofolate";2:cpd00004:0:0:"NADH";1:cpd00125:0:0:"5-10-Methylenetetrahydrofolate";2:cpd11621:0:0:"Oxidizedferredoxin"	[SW] New reaction for EC 1.5.1.M4 within the Ljungdahl-Wood pathway	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-21797&&detail-level=2		MET-HDR birfurcating	methylene tetrahydrofolate reductase (bifurcating)	
rxn14108		TRUE		[SW] Not reported with ferredoxin					
									
rxn16350	<			[SW] electron bifurcating hydrogenase (can be left to right at high hydrogen partial pressure > 50-100 mbar)	https://dx.doi.org/10.1074%2Fjbc.M112.395038		HYD-bif-NAD	electron bifurcating hydrogenase (NAD, ferredoxin)	
rxn90072	<		-1:cpd00011:0:0:"CO2";-1:cpd11640:0:0:"H2";1:cpd00047:0:0:"Formate";1:cpd00067:0:0:"H+"	[SW] hydrogenase based formate dehydrogenase for CO2 assimilation; possible entry to Ljungdahl-Wood pathway (can be left to right at high hydrogen and CO2 partial pressur with e.g. both > 100 mbar)	https://doi.org/10.1186/1475-2859-12-118 https://doi.org/10.3389/fbioe.2020.621166		FDH-hydrogenase	formate dehydrogenase (hydrogenase)	
rxn13847		TRUE		[SW] Reaction not found in MetaCyc nor RHEA. Reducing agent is most likely NADH and not H2 (see 1.1.1.103)					
rxn12136			-2:cpd00005:0:0:"NADPH";-2:cpd00067:0:0:"H+";-2:cpd16529:0:0:"Cinchoninone";2:cpd00006:0:0:"NADP";1:cpd03938:0:0:"Cinchonine";1:cpd08233:0:0:"Cinchonidine"	[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9212				
rxn12137			-2:cpd00005:0:0:"NADPH";-2:cpd00067:0:0:"H+";-2:cpd16531:0:0:"Quinidinone";2:cpd00006:0:0:"NADP";1:cpd03936:0:0:"Quinine";1:cpd03937:0:0:"Quinidine"						
rxn00157	<			[SW] Adjusted according to EcoCyc	https://ecocyc.org/ECOLI/NEW-IMAGE?type=REACTION&object=PYRUVFORMLY-RXN				
rxn10480			-1:cpd00067:1:0:"H+";-1:cpd00204:0:0:"CO";1:cpd00204:1:0:"CO";1:cpd00067:0:0:"H+"	[SW] Since carbon monoxide is stored in the metabolite DB as protonated version (COH), diffusion needs to be implemented as proton antiport in order to achieve a net exchange of CO only					
rxn03641	>			[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-8889				
rxn03642	>			[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-20447				
rxn14087			-1:cpd00308:0:0:"Malonate";-1:cpd11494:0:0:"Acetyl-ACP";1:cpd00029:0:0:"Acetate";1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-"	[SW] Mass and charge balanced					
									
rxn15620	>			[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-15105				
rxn15621	>			[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-15105				
rxn14350	>			[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?object=ERYTHRONOLIDE-SYNTHASE-RXN&&redirect=T				
rxn14196	>			[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?object=ERYTHRONOLIDE-SYNTHASE-RXN&&redirect=T				
rxn19214				[JZ] part of 7alpha-dehydroxylation					TRUE
									
rxn16344	>			[SW] Might be important for photosynthesis	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=THIOREDOXIN-RXN				
									
rxn00268	<			[SW] Corrected according to MetaCyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=GLYCINE-DEHYDROGENASE-RXN				
rxn00690	>			[SW] Corrected according to MetaCyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=FORMATETHFLIG-RXN				
									
rxn11676	<			[SW] Corrected according to MetaCyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-7566				
rxn11677	<			[SW] Corrected according to MetaCyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=1.21.4.3-RXN				
rxn05239	>			[SW] Corrected according to MetaCyc	https://biocyc.org/ECOLI/NEW-IMAGE?type=REACTION&object=1.8.4.8-RXN				
									
rxn13098		TRUE		[SW] Wrong thioredoxin identifier (red)					
rxn13078		TRUE		[SW] Wrong thioredoxin identifier (red)					
rxn13079		TRUE		[SW] Wrong thioredoxin identifier (red)					
rxn13080		TRUE		[SW] Wrong thioredoxin identifier (red)					
rxn13081		TRUE		[SW] Wrong thioredoxin identifier (red)					
rxn13135		TRUE		[SW] Wrong thioredoxin identifier (red)					
rxn13136		TRUE		[SW] Wrong thioredoxin identifier (red)					
rxn13137		TRUE		[SW] Wrong thioredoxin identifier (red)					
rxn13138		TRUE		[SW] Wrong thioredoxin identifier (red)					
									
rxn90084	>		-1:cpd15380:0:0:"5'-deoxyribose";-1:cpd00002:0:0:"ATP";1:cpd00008:0:0:"ADP";1:cpd16441:0:0:"5-Deoxyribose-1-phosphate";1:cpd00067:0:0:"H+"	[SW] New reaction for 5-deoxyadenosine salvage	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-21317		sm5trk	S-methyl-5-thioribose kinase	
rxn39250	>		-1:cpd00009:0:0:"Phosphate";-1:cpd03091:0:0:"5-Deoxyadenosine";1:cpd00128:0:0:"Adenine";1:cpd16441:0:0:"5-Deoxyribose-1-phosphate"	[SW] Reaction corrected for 5-deoxyadenosine salvage pathway	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-8131				
rxn39251	=		-1:cpd16441:0:0:"5-Deoxyribose-1-phosphate";1:cpd30797:0:0:"5-deoxy-D-ribulose-1-phosphate"	[SW] Reaction corrected for 5-deoxyadenosine salvage pathway	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-8131		sm5tr1pi	S-methyl-5-thioribose-1-phosphate isomerase	
rxn39252	=		-1:cpd30797:0:0:"5-deoxy-D-ribulose-1-phosphate";1:cpd00071:0:0:"Acetaldehyde";1:cpd00095:0:0:"Glycerone-phosphate"	[SW] Reaction corrected for 5-deoxyadenosine salvage pathway	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-8131				
									
rxn23045				[SW] Reaction required for aerobic thiamine biosynthesis	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-12614				TRUE
rxn07291		TRUE		[SW] duplicate reaction to rxn25839. Removing rxn07291					
rxn07292		TRUE		[SW] duplicate reaction to rxn25837. Removing rxn07292					
rxn07293		TRUE		[SW] incomplete reaction and dead end					
rxn07294		TRUE		[SW] incomplete reaction and dead end					
									
rxn90085	>		-1:cpd00313:0:0:"Quercetin";-1:cpd00005:0:0:"NADPH";-2:cpd00067:0:0:"H+";1:cpd01135:0:0:"Taxifolin";1:cpd00006:0:0:"NADP"	[SW] new pathway for anaerobic quercetin degradation	10.1128/AEM.67.12.5558-5567.2001		Quc-red	Quercetin reductase	
rxn90086	=		-1:cpd01135:0:0:"Taxifolin";1:cpd90015:0:0:"Alphitonin"	[SW] new pathway for anaerobic quercetin degradation. Chalcone isomerase EC 5.5.1.6	10.1128/JB.00490-16		tai	Taxofolin isomerase	
rxn90087	>		-1:cpd90015:0:0:"Alphitonin";-2:cpd00001:0:0:"H2O";-1:cpd00003:0:0:"NAD";1:cpd00004:0:0:"NADH";2:cpd00067:0:0:"H+";1:cpd00011:0:0:"CO2";1:cpd01473:0:0:"Phloroglucinol";1:cpd00854:0:0:"Homoprotocatechuate"	[SW] new pathway for anaerobic quercetin degradation	10.1128/AEM.67.12.5558-5567.2001		Alph-decarboxy-oxi	Alphitonine decarboxylase (oxidative)	
rxn90088	>		-1:cpd00001:0:0:"H2O";-1:cpd00002:0:0:"ATP";-1:cpd00313:1:0:"Quercetin";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate";1:cpd00313:0:0:"Quercetin";1:cpd00067:0:0:"H+"	[SW] ABC transporter for Quercetin import			Quc-abc-transport	Quercetin ABC transporter (putative)	
rxn90089	=		-1:cpd00854:0:0:"Homoprotocatechuate";-1:cpd00067:0:0:"H+";1:cpd00854:1:0:"Homoprotocatechuate";1:cpd00067:1:0:"H+"	[SW] Homoprotocatechuate/3,4-dihydroxyphenyl-acetate permease			34DOPACpermease	3,4-dihydroxyphenylacetate permease (putative)	
									
rxn43573	>		-1:cpd07946:0:0:4-Hydroxybutyryl-CoA;1:cpd00001:0:0:H2O;1:cpd00650:0:0:Crotonyl-CoA	[JZ] Added from new seed reactions + forward direction only	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-8890			4-hydroxybutanoyl-CoA dehydratase	
rxn32427			-1:cpd00006:0:0:"NADP";-1:cpd12173:0:0:"Reduced flavodoxin";1:cpd00005:0:0:"NADPH";1:cpd12207:0:0:"Oxidized flavodoxin";2:cpd00067:0:0:"H+"	[SW] approved reaction	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=FLAVONADPREDUCT-RXN		FPR	Flavodoxin-NADP+ reductase 	TRUE
									
rxn90090	>		-1:cpd00007:0:0:"O2";-1:cpd00013:0:0:"NH3";-1:cpd15561:0:0:"Ubiquinol-8";1:cpd00001:0:0:"H2O";1:cpd00067:0:0:"H+";1:cpd00165:0:0:"Hydroxylamine";1:cpd15560:0:0:"Ubiquinone-8"	[JZ] Electron carrier is not certain but quinone pool is used in other metabolic models	https://amb-express.springeropen.com/track/pdf/10.1186/s13568-018-0635-y.pdf		AMO	ammonia monooxygenase	
rxn40053	>		-1:cpd00001:0:0:"H2O";-4:cpd00109:0:0:"Cytochrome c3+";-1:cpd00165:0:0:"Hydroxylamine";5:cpd00067:1:0:"H+";1:cpd00075:0:0:"Nitrite";4:cpd00110:0:0:"Cytochrome c2+"	[JZ] imported from new seed reactions + corrected to only forward + proton pumping	https://modelseed.org/biochem/reactions/rxn40053 https://amb-express.springeropen.com/track/pdf/10.1186/s13568-018-0635-y.pdf 		HAO	hydroxylamine dehydrogenase	
rxn90091	>		-1:cpd00001:0:0:"H2O";-1:cpd00075:0:0:"Nitrite";-2:cpd00109:0:0:"Cytochrome c3+";2:cpd00067:0:0:"H+";1:cpd00209:0:0:"Nitrate";2:cpd00110:0:0:"Cytochrome c2+"	[JZ] identical to rxn20694 but with different cytochrome pair	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=P282-PWY		NOR	Nitrite oxidoreductase	
rxn90092	>		-3:cpd00067:1:0:"H+";-2:cpd00110:0:0:"Cytochrome c2+";-1:cpd15560:0:0:"Ubiquinone-8";2:cpd00109:0:0:"Cytochrome c3+";1:cpd15561:0:0:"Ubiquinol-8";1:cpd00067:0:0:"H+"	[JZ] Electrons from cytochrome are transferred to quinone pool (hypothetical in amonia oxidation)	https://amb-express.springeropen.com/track/pdf/10.1186/s13568-018-0635-y.pdf https://core.ac.uk/download/pdf/82626765.pdf		QRED	Quinone reductase	
rxn90093	<		-1:cpd00001:0:0:"H2O";-1:cpd00418:0:0:"NO";-1:cpd00109:0:0:"Cytochrome c3+";2:cpd00067:0:0:"H+";1:cpd00075:0:0:"Nitrite";1:cpd00110:0:0:"Cytochrome c2+"	[JZ] identical to rxn20286 but with different cytochrome pair	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=NITRITE-REDUCTASE-CYTOCHROME-RXN		NIR	Nitrite reductase (NO forming)	
rxn90094	=		-1:cpd00001:0:0:"H2O";-1:cpd00659:0:0:"Nitrous oxide";-2:cpd00109:0:0:"Cytochrome c3+";2:cpd00067:1:0:"H+";2:cpd00418:0:0:"NO";2:cpd00110:0:0:"Cytochrome c2+"	[JZ] identical to rxn20282 but with different cytochrome pair and periplasm protons	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=NITRIC-OXIDE-REDUCTASE-RXN		NOR	nitric oxide reductase (cytochrome c)	
rxn90095	<		-1:cpd00001:0:0:"H2O";-1:cpd00528:0:0:"N2";-2:cpd00109:0:0:"Cytochrome c3+";2:cpd00067:1:0:"H+";1:cpd00659:0:0:"Nitrous oxide";2:cpd00110:0:0:"Cytochrome c2+"	[JZ] identical to rxn22446 but with different cytochrome pair and periplasm protons	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-12130		N2OR	nitrous-oxide reductase	
									
rxn90096	>		-1:cpd00971:0:0:"Na+";-1:cpd00067:1:0:"H+";-1:cpd00519:0:0:"D-methylmalonyl-CoA";1:cpd00011:0:0:"CO2";1:cpd00086:0:0:"Propionyl-CoA";1:cpd00971:1:0:"Na+"	[SW] Reaction can generate a sodium gradient for subsequent ATP production in Veillonella 	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-19738		MMalCoA-DC-Na	S-methylmalonyl-CoA decarboxylase (sodium-transporting) 	
rxn90097	>		-1:cpd03971:0:0:"Genistein";-2:cpd00005:0:0:"NADPH";-2:cpd00067:0:0:"H+";1:cpd90016:0:0:"6'-Hydroxy-O-desmethylangolensin";2:cpd00006:0:0:"NADP"	[SW] new pathway for anaerobic genistein degradation	Schoefer et al. FEMS Microbiology Letters 208 (2002) 197-202		Gsn-red	Genistein reductase	
rxn90098	>		-1:cpd00001:0:0:"H2O";-1:cpd00002:0:0:"ATP";-1:cpd03971:1:0:"Genistein";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate";1:cpd03971:0:0:"Genistein";1:cpd00067:0:0:"H+"	[SW] ABC transporter for Genistein import			Gsn-abc-transport	Genistein ABC transporter (putative)	
rxn90099	=		-1:cpd01975:0:0:"2-(4-Hydroxyphenyl)-propionate";-1:cpd00067:0:0:"H+";1:cpd01975:1:0:"2-(4-Hydroxyphenyl)-propionate";1:cpd00067:1:0:"H+"	[SW] 2-(4-Hydroxyphenyl)-propionate permease			4OPPPA-permease	 2-(4-Hydroxyphenyl)-propionate permease (putative)	
rxn90100	>		-1:cpd90016:0:0:"6'-Hydroxy-O-desmethylangolensin";-1:cpd00001:0:0:"H2O";1:cpd00067:0:0:"H+";1:cpd01473:0:0:"Phloroglucinol";1:cpd01975:0:0:"2-(4-Hydroxyphenyl)-propionate"	[SW] Part of proposed anaerobic Genistein degradation as in E. ramulus	Schoefer et al. FEMS Microbiology Letters 208 (2002) 197-202		6O-O-Desmetyl-AGL	6'-Hydroxy-O-desmethylangolensin hydrolase	
									
rxn09809		TRUE		[SW] model specific reaction					
rxn09726		TRUE		[SW] model specific reaction					
rxn05510		TRUE		[SW] generic reaction.					
rxn12877		TRUE		[SW] model specific reaction					
rxn13038		TRUE		[SW] model specific reaction					
rxn13040		TRUE		[SW] generic reaction.					
									
rxn47991	>		-1:cpd00001:0:0:"H2O";-1:cpd35525:0:0:"1-(6-sulfo-alpha-D-quinovosyl)glycerol";1:cpd00100:0:0:"Glycerol";1:cpd22614:0:0:"sulfoquinovose"	[SW] imported from new seed reactions. Important for sulfoquinovose degradation	https://biocyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7446		sulfoquinovosidase	sulfoquinovosidase	
rxn48462	=		-1:cpd22614:0:0:"sulfoquinovose";1:cpd35501:0:0:"6-deoxy-6-sulfo-D-fructose"	[SW] imported from new seed reactions. Important for sulfoquinovose degradation	https://biocyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7446		sulfoquinovose isomerase	sulfoquinovose isomerase	
rxn41748	>		-1:cpd00002:0:0:"ATP";-1:cpd35501:0:0:"6-deoxy-6-sulfo-D-fructose";1:cpd00008:0:0:"ADP";1:cpd00067:0:0:"H+";1:cpd32891:0:0:"6-deoxy-6-sulfo-D-fructose 1-phosphate"	[SW] imported from new seed reactions. Important for sulfoquinovose degradation	https://biocyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7446		sulfofructose kinase	sulfofructose kinase	
rxn42916	>		-1:cpd32891:0:0:"6-deoxy-6-sulfo-D-fructose 1-phosphate";1:cpd00095:0:0:"Glycerone-phosphate";1:cpd31357:0:0:"2-Hydroxy-3-oxopropane-1-sulfonate"	[SW] imported from new seed reactions. Important for sulfoquinovose degradation	https://biocyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7446		sulfofructosephosphate aldolase	sulfofructosephosphate aldolase	
rxn40453	<		-1:cpd00003:0:0:"NAD";-1:cpd31356:0:0:"2,3-Dihydroxypropane-1-sulfonate";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd31357:0:0:"2-Hydroxy-3-oxopropane-1-sulfonate"	[SW] imported from new seed reactions. Important for sulfoquinovose degradation	https://biocyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7446		sulfolactaldehyde 3-reductase	sulfolactaldehyde 3-reductase	
									
rxn90101	=		-1:cpd22614:1:0:"sulfoquinovose";-1:cpd00067:1:0:"H+";1:cpd22614:0:0:"sulfoquinovose";1:cpd00067:0:0:"H+"	[SW] Importer of sulfoquinovose	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=TRANS-RXN0-580		sulfoquinovose transporter	putative sulfoquinovose transporter	
rxn90102	=		-1:cpd31356:1:0:"(S)-2,3-Dihydroxypropane-1-sulfonate";-1:cpd00067:1:0:"H+";1:cpd31356:0:0:"(S)-2,3-Dihydroxypropane-1-sulfonate";1:cpd00067:0:0:"H+"	[SW] Importer for DHPS			DHPS transporter	DHPS transporter	
									
rxn90103	>		-1:cpd00003:0:0:"NAD";-5:cpd00001:0:0:"H2O";-5:cpd00002:0:0:"ATP";1:cpd00004:0:0:"NADH";5:cpd00008:0:0:"ADP";5:cpd00009:0:0:"Phosphate";4:cpd00067:0:0:"H+"	[JZ] Reduction of NAD needed for reverse electron transport in chemolithotrophy	10.1016/j.watres.2019.01.054			Reverse electron transport to NAD	
rxn90104	>		-1:cpd00006:0:0:"NADP";-5:cpd00001:0:0:"H2O";-5:cpd00002:0:0:"ATP";1:cpd00005:0:0:"NADPH";5:cpd00008:0:0:"ADP";5:cpd00009:0:0:"Phosphate";4:cpd00067:0:0:"H+"	[JZ] Reduction of NADP needed for reverse electron transport in chemolithotrophy	10.1016/j.watres.2019.01.054			Reverse electron transport to NADP	
									
rxn13935		TRUE		[SW] Scaled duplicate to rxn08972					
rxn13945		TRUE		[SW] Scaled duplicate to rxn08972					
rxn13928		TRUE		[SW] Scaled duplicate to rxn08972					
rxn13927		TRUE		[SW] Scaled duplicate to rxn08972					
rxn10122		TRUE		[SW] Scaled duplicate to rxn08972					
									
rxn00551	>			[SW] reverse transformation (f16p - > f6p) is facilitated by different enzymes: EC  4.1.2.13, EC 2.7.1.146, EC 3.1.3.11					
rxn15298	>			[SW] reverse transformation (f16p - > f6p) is facilitated by different enzymes: EC  4.1.2.13, EC 2.7.1.146, EC 3.1.3.11					
rxn00553	>			[SW] changed according to metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=SUCROSE-PHOSPHATE-SYNTHASE-RXN				
									
rxn01215	>			[SW] Unsure. Described for formation of g16p and exergonic	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GLUCOSE-16-BISPHOSPHATE-SYNTHASE-RXN				
rxn00258		TRUE		[SW] EC 2.1.3.1 acts on Propionyl-CoA and not on Acetyl-CoA	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=2.1.3.1-RXN				
									
rxn05231	>			[SW] changed according to metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ADPREDUCT-RXN				
rxn05232	>			[SW] changed according to metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ADPREDUCT-RXN				
rxn05233	>			[SW] changed according to metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GDPREDUCT-RXN				
rxn05234	>			[SW] changed according to metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GDPREDUCT-RXN				
rxn05235	>			[SW] changed according to metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GDPREDUCT-RXN				
rxn05236	>			[SW] changed according to metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GDPREDUCT-RXN				
rxn06076	<			[SW] changed according to metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GDPREDUCT-RXN				
rxn06075	<			[SW] changed according to metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=GDPREDUCT-RXN				
									
rxn00520	>			[SW] highly exergonic according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-12511				
rxn33785		TRUE		[SW] duplicate to rxn00520. Removing					
									
rxn10981		TRUE		[SW] no equivalent in other databases except one specific model from BIGG	https://modelseed.org/biochem/reactions/rxn10981				
									
rxn00622		TRUE		[SW] generic reaction: Alcohol					
rxn01078		TRUE		[SW] generic reaction: Alcohol					
rxn04035		TRUE		[SW] generic reaction: Alcohol					
rxn05874		TRUE		[SW] generic reaction: Alcohol					
rxn05876		TRUE		[SW] generic reaction: Alcohol					
rxn06005		TRUE		[SW] generic reaction: Alcohol					
rxn06035		TRUE		[SW] generic reaction: Alcohol					
rxn06184		TRUE		[SW] generic reaction: Alcohol					
rxn06328		TRUE		[SW] generic reaction: Alcohol					
rxn06349		TRUE		[SW] generic reaction: Alcohol					
rxn15210		TRUE		[SW] generic reaction: Alcohol					
rxn15211		TRUE		[SW] generic reaction: Alcohol					
rxn15242		TRUE		[SW] generic reaction: Alcohol					
rxn15243		TRUE		[SW] generic reaction: Alcohol					
rxn16302		TRUE		[SW] generic reaction: Alcohol					
rxn16303		TRUE		[SW] generic reaction: Alcohol					
rxn05875		TRUE		[SW] generic reaction: Alcohol					
rxn05877		TRUE		[SW] generic reaction: Alcohol					
rxn05878		TRUE		[SW] generic reaction: Alcohol					
rxn06573		TRUE		[SW] generic reaction: Alcohol					
rxn06615		TRUE		[SW] generic reaction: Alcohol					
rxn11604		TRUE		[SW] generic reaction: Alcohol					
rxn12013		TRUE		[SW] generic reaction: Alcohol					
rxn15464		TRUE		[SW] generic reaction: Alcohol					
rxn15465		TRUE		[SW] generic reaction: Alcohol					
rxn11042		TRUE		[SW] generic reaction: an acyl-CoA					
rxn11061		TRUE		[SW] generic reaction: an acyl-CoA					
rxn11044		TRUE		[SW] generic reaction: a trans-enoyl-CoA(n)					
rxn11043		TRUE		[SW] generic reaction: a trans-enoyl-CoA(n)					
rxn11041		TRUE		[SW] generic reaction: a fatty-acid(n)					
rxn11042		TRUE		[SW] generic reaction: a fatty-acid(n)					
rxn16265		TRUE		[SW] generic reaction: Acceptor beta-D-glucuronoside					
rxn12330		TRUE		[SW] Generic/model-specific reaction					
									
rxn02260	>			[SW] changed according to metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-6384				
rxn16149	<			[SW] changed according to metacyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-8974				
rxn00503	>			[SW] changed according to metacyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=PYRROLINECARBDEHYDROG-RXN				
rxn00504	>			[SW] changed according to metacyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=PYRROLINECARBDEHYDROG-RXN				
rxn20649	>			[SW] changed according to metacyc	https://biocyc.org/META/NEW-IMAGE?type=REACTION&object=PYRROLINECARBDEHYDROG-RXN				
									
rxn08986		TRUE		[SW] duplicate reaction to rxn05466					
rxn08987		TRUE		[SW] duplicate reaction to rxn05466					
rxn09736		TRUE		[SW] duplicate reaction to rxn05466					
rxn09835		TRUE		[SW] duplicate reaction to rxn05466					
rxn13364		TRUE		[SW] duplicate reaction to rxn05466					
rxn29187		TRUE		[SW] duplicate reaction to rxn05466					
rxn29241		TRUE		[SW] duplicate reaction to rxn05466					
rxn29242		TRUE		[SW] duplicate reaction to rxn05466					
									
rxn11750			-1:cpd00009:0:0:"Phosphate";-1:cpd16329:0:0:"Doxifluridine";1:cpd04810:0:0:"5-FU";1:cpd16441:0:0:"5-Deoxyribose-1-phosphate"	[SW] Corrected charge and mass balance.					
rxn11029			-1:cpd00067:0:0:"H+";-1:cpd00004:0:0:"NADH";-1:cpd16121:0:0:"2,5-diketo-3-deoxygluconate";1:cpd00003:0:0:"NAD";1:cpd00176:0:0:"2-keto-3-deoxygluconate"	[SW] Corrected charge and mass balance.					
rxn12333			-1:cpd03584:0:0:"UDP-3-O-(beta-hydroxymyristoyl)-D-glucosamine";-1:cpd16594:0:0:"3-hydroxyacyl-acp";1:cpd02835:0:0:"UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine";1:cpd11493:0:0:"ACP";1:cpd00067:0:0:"H+"	[SW] Corrected charge and mass balance.					
rxn11345			-1:cpd00067:0:0:"H+";-1:cpd00869:0:0:"4-methylthio 2-oxobutyrate";1:cpd00011:0:0:"CO2";1:cpd16244:0:0:"MTAL"						
									
rxn13006		TRUE		[SW] Duplicate reaction to rxn08043 but with wrong metabolite identifier					
rxn13009		TRUE		[SW] Duplicate reaction to rxn08764 but with wrong metabolite identifier					
rxn11512		TRUE		[SW] Incomplete and unbalanced reaction					
rxn08257	=			[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-14936				
rxn09422			-6:cpd00005:0:0:"NADPH";-9:cpd00067:0:0:"H+";-3:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd11494:0:0:"Acetyl-ACP";3:cpd00001:0:0:"H2O";6:cpd00006:0:0:"NADP";3:cpd00011:0:0:"CO2";1:cpd11470:0:0:"Octanoyl-ACP";3:cpd11493:0:0:"ACP"	[SW] Corrected charge and mass balance.					
rxn09428			-2:cpd00005:0:0:"NADPH";-3:cpd00067:0:0:"H+";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";-1:cpd15277:0:0:"Palmitoyl-ACP";1:cpd00001:0:0:"H2O";2:cpd00006:0:0:"NADP";1:cpd00011:0:0:"CO2";1:cpd11493:0:0:"ACP";1:cpd15268:0:0:"Octadecanoyl-ACP"	[SW] Corrected charge and mass balance.					
rxn09439			-2:cpd00005:0:0:"NADPH";-3:cpd00067:0:0:"H+";-1:cpd11474:0:0:"Decanoyl-ACP";-1:cpd11492:0:0:"Malonyl-acyl-carrierprotein-";1:cpd00001:0:0:"H2O";2:cpd00006:0:0:"NADP";1:cpd00011:0:0:"CO2";1:cpd11468:0:0:"Dodecanoyl-ACP";1:cpd11493:0:0:"ACP"	[SW] Corrected charge and mass balance.					
rxn11091	>		-1:cpd00003:0:0:"NAD";-1:cpd16167:0:0:"dihydroorotate";1:cpd00004:0:0:"NADH";1:cpd00247:0:0:"Orotate";1:cpd00067:0:0:"H+"	[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=OROTATE-REDUCTASE-NADH-RXN				
rxn11157			-1:cpd00067:0:0:"H+";-1:cpd00343:0:0:"N-Carbamoyl-L-aspartate";1:cpd00001:0:0:"H2O";1:cpd16167:0:0:"dihydroorotate"	[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=DIHYDROOROT-RXN				
rxn14270			-1:cpd00017:0:0:"S-Adenosyl-L-methionine";-1:cpd08368:0:0:"Cobalt-precorrin 2";1:cpd00019:0:0:"S-Adenosyl-homocysteine";1:cpd17535:0:0:"Cobalt-factor III"	[SW] Corrected charge and mass balance.					
									
rxn23867			-1:cpd00001:0:0:"H2O";-1:cpd07105:0:0:"Daidzin";1:cpd00027:0:0:"D-Glucose";1:cpd07097:0:0:"Daidzein"	[SW] Replaced Glucose identifier to standard					
rxn22013	>		-1:cpd00005:0:0:"NADPH";-1:cpd00067:0:0:"H+";-1:cpd07097:0:0:"Daidzein";1:cpd00006:0:0:"NADP";1:cpd90018:0:0:"(R)-4',7-dihydroxyisoflavanone"	[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-11640				
rxn90105	=		-1:cpd90018:0:0:"(R)-4',7-dihydroxyisoflavanone";1:cpd23494:0:0:"(S)-4',7-dihydroxyisoflavanone"	[SW] Newly introduced based on new MetaCyc reaction	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-22410		dihydrodaizein racemase	dihydrodaizein racemase	
rxn23386	>			[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-13101				
rxn23387	>		-2:cpd24186:0:0:"(3R,4S)-tetrahydrodaidzein";1:cpd00001:0:0:"H2O";1:cpd09832:0:0:"Equol";1:cpd23494:0:0:"(S)-4',7-dihydroxyisoflavanone"	[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-13102		tetrahydrodaidzein reductase	tetrahydrodaidzein reductase	
rxn90106	=		-1:cpd09832:1:0:"Equol";1:cpd09832:0:0:"Equol"	[SW] Putative equol permease			Equol permease	Equol permease	
rxn90107	=		-1:cpd07097:1:0:"Daidzein";1:cpd07097:0:0:"Daidzein"	[SW] Putative daidzein permease			Daidzein permease	Daidzein permease	
rxn90108	=		-1:cpd07105:1:0:"Daidzin";1:cpd07105:0:0:"Daidzin"	[SW] Putative daidzin permease			Daidzin permease	Daidzin permease	
									
rxn20839				[SW] Reaction in archaeal mevalonate pathway IV					TRUE
rxn13772	>		-1:cpd90019:0:0:"trans-anhydromevalonate 5-phosphate";-1:cpd00067:0:0:"H+";1:cpd00011:0:0:"CO2";1:cpd17039:0:0:"Isopentenyl phosphate"	[SW] Reaction in archaeal mevalonate pathway IV and corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-21278		anhydromevalonate phosphate decarboxylase	anhydromevalonate phosphate decarboxylase	
rxn90109	>		-1:cpd00812:0:0:"5-phosphomevalonate";1:cpd90019:0:0:"trans-anhydromevalonate 5-phosphate";1:cpd00001:0:0:"H2O"	[SW] Reaction in archaeal mevalonate pathway IV	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-21277		phosphomevalonate dehydratase	phosphomevalonate dehydratase	
rxn20838			-1:cpd00002:0:0:"ATP";-1:cpd00812:0:0:"5-phosphomevalonate";1:cpd00011:0:0:"CO2";1:cpd17039:0:0:"Isopentenyl phosphate";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate"	[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-10067				
rxn43975	>		-1:cpd00002:0:0:"ATP";-1:cpd00332:0:0:"Mevalonic acid";1:cpd00008:0:0:"ADP";1:cpd00067:0:0:"H+";1:cpd33518:0:0:"(R)-mevalonate 3-phosphate"	[SW] Reaction required for mevalonic acid pathway II (Thermoplasma)	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-15647		mevalonate-3-kinase	mevalonate-3-kinase	
rxn42732	>		-1:cpd33518:0:0:"(R)-mevalonate 3-phosphate";-1:cpd00002:0:0:"ATP";1:cpd00008:0:0:"ADP";1:cpd00067:0:0:"H+";1:cpd27451:0:0:"3,5-diphosphomevalonate"	[SW] Reaction required for mevalonic acid pathway II (Thermoplasma)	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-15648		mevalonate-3-phosphate-5-kinase	mevalonate-3-phosphate-5-kinase	
rxn41263	>		-1:cpd00067:0:0:"H+";-1:cpd27451:0:0:"3,5-diphosphomevalonate";1:cpd00009:0:0:"Phosphate";1:cpd00011:0:0:"CO2";1:cpd17039:0:0:"Isopentenyl phosphate"	[SW] Reaction required for mevalonic acid pathway II (Thermoplasma)	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-15649		bisphosphomevalonate decarboxylase	bisphosphomevalonate decarboxylase	
									
rxn20827	>			[SW] Reaction required for 3-dehydroquinate biosynthesis in some archaea and corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-10053				
rxn33374		TRUE		[SW] duplicate reaction to rxn01643					
									
rxn28980		TRUE		[SW] duplicate reaction to rxn03147					
rxn27691		TRUE		[SW] duplicate reaction to rxn03136					
rxn35698		TRUE		[SW] duplicate reaction to rxn03136					
rxn27692		TRUE		[SW] duplicate reaction to rxn03137					
rxn27945		TRUE		[SW] duplicate reaction to rxn00832					
rxn19830		TRUE		[SW] duplicate reaction to rxn03135					
rxn37546		TRUE		[SW] duplicate reaction to rxn03147					
rxn41476	>		-1:cpd00008:0:0:"ADP";-1:cpd00475:0:0:" Ribose 1-phosphate";1:cpd00018:0:0:"AMP";1:cpd00847:0:0:"Ribose 1,5-bisphosphate"	[SW] Reaction required in nucleoside and nucleotide degradation in some archaea, EC 2.7.1.212	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-17337		D-ribose-1-phosphate 5-kinase (ADP) 	D-ribose-1-phosphate 5-kinase (ADP) 	
									
rxn13659		TRUE		[SW] Reaction not found in MetaCyc nor RHEA, BIGG, etc.					
rxn28327		TRUE		[SW] duplicate reaction to rxn00616					
									
rxn09953	>			[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-9718				
rxn15597		TRUE		[SW] aggregate reaction with EC 3.2.1.4 and 3.2.1.91. These should not be aggregated					
rxn90110	>		-4:cpd11746:1:0:"Cellulose";-1:cpd00001:1:0:"H2O";1:cpd01376:1:0:"Cellotetraose"	[SW] Extracellular cellulase			Exo-cellulase	Exo-cellulase	
rxn90111	>		-1:cpd01376:1:0:"Cellotetraose";-1:cpd00001:1:0:"H2O";2:cpd00158:1:0:"D-Cellobiose"	[SW] Extracellular cellobiohydrolase			Exo-cellobiohydrolase	Exo-cellobiohydrolase	
									
rxn15999	>			[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-9891				
rxn16000	>			[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-9891				
rxn01474	<			[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.1.1.43-RXN				
rxn01475	<			[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.1.1.43-RXN				
									
rxn27926		TRUE		[SW] duplicate reaction to rxn02320					
rxn32479		TRUE		[SW] duplicate reaction to rxn02373					
rxn34566		TRUE		[SW] duplicate reaction to rxn02373					
rxn34567		TRUE		[SW] duplicate reaction to rxn02373					
rxn33819		TRUE		[SW] duplicate reaction to rxn00183					
rxn33820		TRUE		[SW] duplicate reaction to rxn00183					
rxn30382		TRUE		[SW] duplicate reaction to rxn02374					
rxn20496		TRUE		[SW] duplicate reaction to rxn00467					
rxn33315		TRUE		[SW] duplicate reaction to rxn00467					
									
rxn00247	=			[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=PEPCARBOXYKIN-RXN				
									
rxn90112	>		-499:cpd00001:1:0:"H2O";-1:cpd90020:1:0:"Cellulose";500:cpd00027:1:0:"D-Glucose"	[JZ] Added from vmh with units per chain n=500 (fibers from cellulose contain 250–500 repeating units per chain cf. 10.1002/anie.200460587)	https://www.vmh.life/#metabolite/cellul		CELLUL_DEGe	Extracellular cellulose degradation	
rxn90113	>		-49:cpd00001:1:0:"H2O";-1:cpd90021:1:0:"Xylan-b-1-4";50:cpd90022:1:0:"Xylooligo-b-1-4"	[SW] Added to have a xylan degradation without ambiguous metabolites	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-6717		xylanase	Extracellular xylan degradation	
rxn90114	>		-9:cpd00001:1:0:"H2O";-1:cpd90022:1:0:"Xylan-b-1-4";10:cpd00154:1:0:"Xylose"	[SW] Added to have a xylan degradation without ambiguous metabolites	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-6717		xylosidase	Extracellular xylooligosaccharide degradation	
rxn09995		TRUE		[SW] Reaction used ambiguous metabolite definition					
rxn15600		TRUE		[SW] Reaction used ambiguous metabolite definition					
rxn15601		TRUE		[SW] Reaction used ambiguous metabolite definition					
rxn15581		TRUE		[SW] Reaction used ambiguous metabolite definition					
									
rxn08854				[JZ] updated reaction name			TRANS-RXN-58	Lysine transporter	
rxn05303								Arginine symporter	
									
rxn24606				[JZ] needed for methanogensis from methanol	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=CO2FORM-PWY				TRUE
rxn24607				[JZ] needed for methanogensis from methanol	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=CO2FORM-PWY				TRUE
									
rxn00453	>			[SW] Corrected according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=O-ACETYLHOMOSERINE-THIOL-LYASE-RXN				
rxn32480		TRUE		[SW] duplicate reaction to rxn10470					
rxn32345		TRUE		[SW] duplicate reaction to rxn00453					
rxn09948	>			[SW] highly exergonic according to MetaCyc	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-18602				
rxn12780		TRUE		[SW] Reaction not found in MetaCyc nor RHEA, BIGG, etc.					
									
rxn11130	>			[JZ] very similar to rxn01068 + wrong reversibility	https://metacyc.org/META/NEW-IMAGE?type=NIL&object=THREODEHYD-RXN&redirect=T			L-threonine:NAD+ oxidoreductase	
									
rxn23106				[SW] Required for iso-LCA biosynthesis (NADPH-dependent)	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7756				TRUE
rxn44816	=		-1:cpd00006:0:0:"NADP";-1:cpd02733:0:0:"Deoxycholate";1:cpd00005:0:0:"NADPH";1:cpd00067:0:0:"H+";1:cpd35799:0:0:"12alpha-hydroxy-3-oxo-5beta-cholan-24-oate"	[SW] Required for iso-DCA biosynthesis (NADPH-dependent)	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7756		3alpha-HSDH-DCA-NADPH	3alpha-hydroxycholanate dehydrogenase (NADP+) utilizing DCA	
rxn41954	=		-1:cpd00003:0:0:"NAD";-1:cpd17773:0:0:"Isolithocholate";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd01967:0:0:"3-Oxo-5beta-cholanate"	[SW] Required for iso-LCA biosynthesis (NADH-dependent)	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7755		3beta-HSDH-LCA-NADH	3beta-hydroxycholanate 3-dehydrogenase (NAD+) forming isoLCA	
rxn42927	=		-1:cpd00003:0:0:"NAD";-1:cpd34659:0:0:"3beta,12alpha-dihydroxy-5beta-cholan-24-oate";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd35799:0:0:"12alpha-hydroxy-3-oxo-5beta-cholan-24-oate"	[SW] Required for iso-DCA biosynthesis (NADH-dependent)	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7755		3beta-HSDH-DCA-NADH	3beta-hydroxycholanate 3-dehydrogenase (NAD+) forming isoDCA	
rxn42689	=		-1:cpd00006:0:0:"NADP";-1:cpd17773:0:0:"Isolithocholate";1:cpd00005:0:0:"NADPH";1:cpd00067:0:0:"H+";1:cpd01967:0:0:"3-Oxo-5beta-cholanate"	[SW] Required for iso-LCA biosynthesis (NADPH-dependent)	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7756		3beta-HSDH-LCA-NADPH	3beta-hydroxycholanate 3-dehydrogenase (NADP+) forming isoLCA	
rxn48035	=		-1:cpd00006:0:0:"NADP";-1:cpd34659:0:0:"3beta,12alpha-dihydroxy-5beta-cholan-24-oate";1:cpd00005:0:0:"NADPH";1:cpd00067:0:0:"H+";1:cpd35799:0:0:"12alpha-hydroxy-3-oxo-5beta-cholan-24-oate"	[SW] Required for iso-DCA biosynthesis (NADPH-dependent)	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7756		3beta-HSDH-DCA-NADPH	3beta-hydroxycholanate 3-dehydrogenase (NADP+) forming isoDCA	
									
rxn33225		TRUE		[SW] duplicate reaction to rxn11689					
rxn33311		TRUE		[SW] duplicate reaction to rxn11689					
rxn32096	=		-1:cpd03778:1:0:"Terephthalate";-2:cpd00067:1:0:"H+";1:cpd03778:0:0:"Terephthalate";2:cpd00067:0:0:"H+"	[SW] Charge-neutral transport of Terephthalate					
rxn32101		TRUE		[SW] duplicate reaction to rxn32096					
rxn23791				[SW] Required for Terephthalate degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=P184-PWY				TRUE
rxn16552				[SW] Required for Terephthalate degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=P184-PWY				TRUE
rxn02143	=		-1:cpd00078:0:0:"Succinyl-CoA";-1:cpd00630:0:0:"3-Oxoadipate";1:cpd00036:0:0:"Succinate";1:cpd01507:0:0:"3-Oxoadipyl-CoA"	[SW] Corrected stoichiometry	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=3-OXOADIPATE-COA-TRANSFERASE-RXN&detail-level=3				
rxn00598	<		-1:cpd00022:0:0:"Acetyl-CoA";-1:cpd00078:0:0:"Succinyl-CoA";1:cpd00010:0:0:"CoA";1:cpd01507:0:0:"3-Oxoadipyl-CoA"	[SW] Corrected stoichiometry	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-3641&detail-level=3				
rxn03078	>			[SW] corrected direction	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=1.2.1.45-RXN				
rxn21189				[SW] Required for Terephthalate degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-6336				TRUE
rxn21190				[SW] Required for Terephthalate degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-6336				TRUE
rxn24985	<			[SW] Required for Terephthalate degradation	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-8529				
rxn18926				[SW] Required for Terephthalate degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-6336				TRUE
rxn17400	>			[SW] Required for aromatic compound degradation	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-5162				
									
rxn30161		TRUE		[SW] duplicate to rxn06936					
rxn06433	>		-1:cpd00002:0:0:"ATP";-1:cpd00041:0:0:"L-Aspartate";-1:cpd11908:0:0:"tRNA(Asn)";1:cpd00012:0:0:"PPi";1:cpd00018:0:0:"AMP";1:cpd12829:0:0:"Asp-tRNA(Asn)";1:cpd00067:0:0:"H+"	[SW] Central reaction in tRNA-dependent Asn biosynthesis	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY490-4			L-Aspartate:tRNAAsn ligase (AMP-forming)	
rxn90115	>		-1:cpd12829:0:0:"Asp-tRNA(Asn)";-1:cpd00053:0:0:"L-Glutamine";-1:cpd00002:0:0:"ATP";-2:cpd00001:0:0:"H2O";1:cpd11908:0:0:"tRNA(Asn)";1:cpd00023:0:0:"L-Glutamate";1:cpd00132:0:0:"L-Asparagine";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate";2:cpd00067:0:0:"H+"	[SW] Central reaction in tRNA-dependent Asn biosynthesis: Note: not 100 percent correct, as no free asn is produced. However the biomass reactions cannot handle asn-tRNA(asn) as its ASN component…	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY490-4		Asp-AdT	asparaginyl-tRNA synthase (glutamine-hydrolysing)	
rxn14309	>		-1:cpd00002:0:0:"ATP";-1:cpd00738:0:0:"phosphoserine";-1:cpd11910:0:0:"tRNA(Cys)";1:cpd00012:0:0:"PPi";1:cpd00018:0:0:"AMP";1:cpd17286:0:0:"O-Phosphoseryl-tRNA(Cys)";1:cpd00067:0:0:"H+"	[SW] Central reaction in tRNA-dependent Cys biosynthesis	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-6308				
rxn14388	>		-1:cpd17286:0:0:"O-Phosphoseryl-tRNA(Cys)";-1:cpd00239:0:0:"H2S";-1:cpd00001:0:0:"H2O";1:cpd00009:0:0:"Phosphate";1:cpd11910:0:0:"tRNA(Cys)";1:cpd00084:0:0:"L-Cysteine"	[SW] Central reaction in tRNA-dependent Cys biosynthesis: Note: not 100 percent correct, as no free Cys is produced. However the biomass reactions cannot handle cys-tRNA(Cys) as its Cys component…	https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-6308			Cys-tRNA synthase 	
									
rxn43343	=		-1:cpd01394:0:0:"Indolelactate";-1:cpd31402:0:0:"3-(indol-3-yl)acryloyl-CoA";1:cpd34089:0:0:"(R)-3-(indol-3-yl)lactoyl-CoA";1:cpd23008:0:0:"3-(3-indolyl)acrylic acid"	[SW] Reaction of PWY-8017	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-19895		FldA	3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase	
rxn40939	>		-1:cpd34089:0:0:"(R)-3-(indol-3-yl)lactoyl-CoA";1:cpd00001:0:0:"H2O";1:cpd31402:0:0:"3-(indol-3-yl)acryloyl-CoA"	[SW] Reaction of PWY-8017	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-19896		fldBC	(R)-3-(aryl)lactoyl-CoA dehydratase	
rxn45361	<		-1:cpd27005:0:0:"ETF-Oxidized";-1:cpd27289:0:0:"indole-3-propionate";-1:cpd00067:0:0:"H+";1:cpd27006:0:0:"ETF-Reduced";1:cpd23008:0:0:"3-(3-indolyl)acrylic acid"	[SW] Reaction of PWY-8017	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-19885		acdA	3-(aryl)acrylate reductase	
rxn90116	=		-1:cpd27289:0:0:"indole-3-propionate";-1:cpd00067:0:0:"H+";1:cpd27289:1:0:"indole-3-propionate";1:cpd00067:1:0:"H+"	[SW] Transport reaction for IPA (indole-3-propionate)			IPA-transport	Indole-3-Propionate transport	
rxn19680	=		-1:cpd00004:0:0:"NADH";-1:cpd27005:0:0:"ETF-Oxidized";-2:cpd00067:0:0:"H+";1:cpd00003:0:0:"NAD";1:cpd27006:0:0:"ETF-Reduced"	[SW] Reaction required to tranfers electrons between NAD(H) and ETF	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=ETFCLOS-RXN		ETF dehydrogenease (NADH)	electron-transferring-flavoprotein dehydrogenase (NADH)	
rxn17738		TRUE		[SW] duplicate reaction to rxn07603; but with redundant identifier for phenyllactate					
rxn43002	>		-1:cpd14973:0:0:"(R)-Phenyllactyl-CoA";1:cpd00001:0:0:"H2O";1:cpd00422:0:0:"Cinnamoyl-CoA";1:cpd00067:0:0:"H+"	[SW] Reaction of PWY-8014	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-19883		aryllactyl-CoA dehydratase 	(R)-3-(aryl)lactoyl-CoA dehydratase	
rxn07603	>		-1:cpd00067:0:0:"H+";-1:cpd03331:0:0:"(R)-phenyllactate";-1:cpd00422:0:0:"Cinnamoyl-CoA";1:cpd00333:0:0:"(E)-Cinnamate";1:cpd14973:0:0:"(R)-Phenyllactyl-CoA"	[SW] Change in identifier for Cinnamoyl-CoA					
rxn40746	<		-1:cpd27005:0:0:"ETF-Oxidized";-1:cpd03343:0:0:"Phenylpropanoate";-1:cpd00067:0:0:"H+";1:cpd27006:0:0:"ETF-Reduced";1:cpd00333:0:0:"(E)-Cinnamate"	[SW] Reaction of PWY-8014	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-19882		3-(aryl)acrylate reductase	3-(aryl)acrylate reductase	
rxn10133		TRUE		[SW] duplicate to rxn09182					
rxn46948	=		-1:cpd00192:0:0:"4-Coumaroyl-CoA";-1:cpd02461:0:0:"(R)-3-(4-Hydroxyphenyl)lactate";1:cpd00604:0:0:"4-Coumarate";1:cpd34727:0:0:"(R)-3-(4-hydroxyphenyl)lactoyl-CoA"	[SW] Reaction of PWY-8016	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-19897		FldA	3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase	
rxn44705	>		-1:cpd34727:0:0:"(R)-3-(4-hydroxyphenyl)lactoyl-CoA";1:cpd00001:0:0:"H2O";1:cpd00192:0:0:"4-Coumaroyl-CoA"	[SW] Reaction of PWY-8016	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-19898		aryllactyl-CoA dehydratase 	(R)-3-(aryl)lactoyl-CoA dehydratase	
rxn12400			-1:cpd00067:1:0:"H+";-1:cpd00604:1:0:"4-Coumarate";1:cpd00067:0:0:"H+";1:cpd00604:0:0:"4-Coumarate"	[SW] Change comparatment of left 4-coumarate (p to e)					
rxn46031	<		-1:cpd00067:0:0:"H+";-1:cpd01202:0:0:"Phloretate";-1:cpd27005:0:0:"ETF-Oxidized";1:cpd00604:0:0:"4-Coumarate";1:cpd27006:0:0:"ETF-Reduced"	[SW] Reaction of PWY-8016	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-19888		3-(aryl)acrylate reductase 	3-(aryl)acrylate reductase 	
rxn90117	=		-1:cpd01202:0:0:"Phloretate";-1:cpd00067:0:0:"H+";1:cpd01202:1:0:"Phloretate";1:cpd00067:1:0:"H+"	[SW] Transport reaction for Phloretate			Phloretate-transport	Phloretate-transport	
									
rxn41427	>		-3:cpd00067:0:0:"H+";-1:cpd00239:0:0:"H2S";-1:cpd00346:0:0:"L-Aspartate4-semialdehyde";-2:cpd11620:0:0:"Reducedferredoxin";1:cpd00001:0:0:"H2O";1:cpd00135:0:0:"Homocysteine";2:cpd11621:0:0:"Oxidizedferredoxin"	[SW] Key-reaction in a methionine bionsynthetic pathway. MetaCyc ID PWY-7977	https://metacyc.org/META/NEW-IMAGE?type=REACTION-IN-PATHWAY&object=RXN-19380		asd-S-transferase	L-aspartate semialdehyde sulfurtransferase	
rxn32690		TRUE		[SW] duplicate reaction to rxn00484					
rxn09326		TRUE		[SW] duplicate reaction to rxn05663					
rxn09709		TRUE		[SW] duplicate reaction to rxn05663					
rxn34411		TRUE		[SW] duplicate reaction to rxn05663					
rxn32036		TRUE		[SW] duplicate reaction to rxn32033					
rxn32039		TRUE		[SW] duplicate reaction to rxn32033					
rxn31860		TRUE		[SW] duplicate reaction to rxn14082					
rxn31864		TRUE		[SW] duplicate reaction to rxn14082					
									
rxn90118	=		-1:cpd00067:1:0:"H+";-1:cpd00318:0:0:"Tryptamine";1:cpd00318:1:0:"Tryptamine";1:cpd00067:0:0:"H+"	[SW] Tryptamine-proton Antiport to ensure charge-neutral transport		transport	tryptamine-proton-antiporter	Tryptamine transport via proton antiport	
rxn05686		TRUE		[SW] Reaction is not charge neutral (transport of net-charge 2)					
rxn90119	=		-1:cpd00067:1:0:"H+";-1:cpd00374:0:0:"Tyramine";1:cpd00374:1:0:"Tyramine";1:cpd00067:0:0:"H+"	[SW] Tyramine-proton Antiport to ensure charge-neutral transport		transport	Tyramine-proton-antiporter	Tyramine transport via proton antiport	
rxn28979		TRUE		[SW] duplicate reaction to rxn00126					
rxn19827		TRUE		[SW] duplicate reaction to rxn00182					
rxn19316		TRUE		[SW] duplicate reaction to rxn00256					
rxn15055		TRUE		[SW] duplicate reaction to rxn00468					
rxn37807		TRUE		[SW] duplicate reaction to rxn00502					
rxn19041		TRUE		[SW] duplicate reaction to rxn00649					
rxn19042		TRUE		[SW] duplicate reaction to rxn00649					
rxn32343		TRUE		[SW] duplicate reaction to rxn00649					
rxn33233		TRUE		[SW] duplicate reaction to rxn00649					
rxn33240		TRUE		[SW] duplicate reaction to rxn05733					
rxn33241		TRUE		[SW] duplicate reaction to rxn05733					
rxn23817		TRUE		[SW] duplicate reaction to rxn05733					
rxn10448		TRUE		[SW] duplicate reaction to rxn08188					
rxn09688		TRUE		[SW] duplicate reaction to rxn08323					
rxn12416		TRUE		[SW] duplicate reaction to rxn08323					
									
rxn18552				[SW] ATP-dependent stachyose import					TRUE
rxn90120	>		-1:cpd00076:0:0:"sucrose";-1:cpd21648:0:0:"6-kestotriose";1:cpd25730:0:0:"6,6-kestotetraose";1:cpd00027:0:0:"D-Glucose"	[SW] Reaction for EC 2.4.1.10	https://metacyc.org/compound?orgid=META&id=6-KESTOSE		levansucrase	levansucrase	
rxn90121	>		-1:cpd21648:0:0:"6-kestotriose";-1:cpd00001:0:0:"H2O";1:cpd00076:0:0:"sucrose";1:cpd00082:0:0:"D-Fructose"	[SW] involved in levan degradation	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.2.1.154-RXN		kestotriose fructosidase	kestotriose fructosidase	
rxn90122	>		-1:cpd25730:0:0:"6,6-kestotetraose";-1:cpd00001:0:0:"H2O";1:cpd21648:0:0:"6-kestotriose";1:cpd00082:0:0:"D-Fructose"	[SW] involved in levan degradation	https://metacyc.org/META/NEW-IMAGE?type=REACTION&object=3.2.1.154-RXN		kestotetraose fructosidase	kestotetraose fructosidase	
rxn17933		TRUE		[SW] highly unbalanced					
rxn17983		TRUE		[SW] highly unbalanced					
rxn90123	>		-1:cpd00155:1:0:"glycogen";-1:cpd00001:1:0:"H2O";1:cpd01262:1:0:"Amylotriose";1:cpd00179:1:0:"Maltose"	[SW] A glycogen hydrolase that hydrolyses (1->6)-α-D-glucosidic branch linkages and releases shorter maltodextrins. Extracellular	https://doi.org/10.1038/s41564-023-01447-2		isoamylase	debranching enzyme, glycogen α-1,6-glucanohydrolase	
									
rxn20665									TRUE
									
rxn29776	>		-1:cpd00001:0:0:"H2O";-1:cpd00002:0:0:"ATP";-1:cpd28763:1:0:"Inulin";1:cpd00008:0:0:"ADP";1:cpd00009:0:0:"Phosphate";1:cpd00067:0:0:"H+";1:cpd28763:0:0:"Inulin"	[JZ] inulin abc transporter					TRUE
rxn90124	>		-1:cpd28763:0:0:"Inulin";-11:cpd00001:0:0:"H2O";11:cpd00082:0:0:"D-Fructose";1:cpd00027:0:0:"D-Glucose"	[JZ] inulinase, intracellular	https://www.vmh.life/#reaction/INULINASE		inulinase	inulinase, intracellular	
									
rxn27362			-1:cpd00067:1:0:"H+";-1:cpd00047:0:0:"Formate";-1:cpd00180:1:0:"Oxalate";1:cpd00067:0:0:"H+";1:cpd00047:1:0:"Formate";1:cpd00180:0:0:"Oxalate"	[SW] Charge-neutral antiport				oxalate formate antiporter	
									
rxn03790	>		-1:cpd04166:1:0:"PCE";-1:cpd15499:0:0:"Menaquinol 8";1:cpd00099:1:0:"Cl-";1:cpd04167:1:0:"TCE";1:cpd00067:1:0:"H+";1:cpd15500:0:0:"Menaquinone 8"	[JZ] corrected direction, added missing electron carrier and changed wrong protonation	https://biocyc.org/reaction?orgid=SMUL&id=1.97.1.8-RXN		pcerd	tetrachloroethene reductive dehalogenase	
rxn03791	>		-1:cpd04167:1:0:"TCE";-1:cpd15499:0:0:"Menaquinol 8";1:cpd00099:1:0:"Cl-";1:cpd04168:1:0:"DCE";1:cpd00067:1:0:"H+";1:cpd15500:0:0:"Menaquinone 8"	[JZ] corrected direction, added missing electron carrier and changed wrong protonation	https://biocyc.org/reaction?orgid=SMUL&id=TCEREDCHLOR-RXN		tcerd	trichloroethene reductive dehalogenase	
									
rxn25906									TRUE
rxn25907									TRUE
rxn25893									TRUE
rxn25894									TRUE
									
rxn40127	>		-1:cpd00098:0:0:"Choline";1:cpd00071:0:0:"Acetaldehyde";1:cpd00441:0:0:"Trimethylamine"	[SW] Choline degradation to TMA	https://www.rhea-db.org/rhea/35095		choline trimethylamine-lyase	choline trimethylamine-lyase	
rxn23816		TRUE		[SW] duplicate reaction to rxn00657					
rxn27956		TRUE		[SW] duplicate reaction to rxn02866					
rxn13962				[SW] Reaction is charge balanced despite the charge imbalance tag in the original table					TRUE
rxn14109				[SW] Reaction is charge balanced despite the charge imbalance tag in the original table					TRUE
rxn14152				[SW] Reaction is charge balanced despite the charge imbalance tag in the original table					TRUE
rxn45233	<		-1:cpd00003:0:0:"NAD";-1:cpd02084:0:0:"D-2-Hydroxyisocaproate";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd00200:0:0:"4MOP"	[SW] Reductive Stickland reaction for Leucine degradation (MetaCyc: PWY-7767)	https://www.rhea-db.org/rhea/10052		D-2-hydroxyacid dehydrogenase (NAD(+))	D-2-hydroxyacid dehydrogenase (NAD(+))	
rxn42773	>		-1:cpd02084:0:0:"D-2-Hydroxyisocaproate";-1:cpd33312:0:0:"4-methylpentanoyl-CoA";1:cpd23040:0:0:"(R)-2-hydroxyisocaproyl-CoA";1:cpd34958:0:0:"4-methylpentanoate"	[SW] Reductive Stickland reaction for Leucine degradation (MetaCyc: PWY-7767)	https://www.rhea-db.org/rhea/49440		(R)-2-hydroxy-4-methylpentanoate CoA-transferase	(R)-2-hydroxy-4-methylpentanoate CoA-transferase	
rxn43902	>		-1:cpd23040:0:0:"(R)-2-hydroxyisocaproyl-CoA";1:cpd00001:0:0:"H2O";1:cpd32069:0:0:"4-methylpent-2-enoyl-CoA"	[SW] Reductive Stickland reaction for Leucine degradation (MetaCyc: PWY-7767)	https://www.rhea-db.org/rhea/46924		(R)-2-hydroxyisocaproyl-CoA dehydratase	(R)-2-hydroxyisocaproyl-CoA dehydratase	
rxn40585	<		-1:cpd00003:0:0:"NAD";-1:cpd33312:0:0:"4-methylpentanoyl-CoA";1:cpd00004:0:0:"NADH";1:cpd00067:0:0:"H+";1:cpd32069:0:0:"4-methylpent-2-enoyl-CoA"	[SW] Reductive Stickland reaction for Leucine degradation (MetaCyc: PWY-7767)	https://www.rhea-db.org/rhea/18177		trans-2-enoyl-CoA reductase (NAD+)	trans-2-enoyl-CoA reductase (NAD+)	
